The role of the chlorine substituents in the antibiotic vancomycin: preparation and characterization of mono- and didechlorovancomycin
Harris, Constance M, Kannan, Rajamoorthi, Kopecka, Hana, Harris, Thomas M
Published in Journal of the American Chemical Society (01.11.1985)
Published in Journal of the American Chemical Society (01.11.1985)
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Vancomycin: structure and transformation to CDP-I
Harris, Constance M, Kopecka, Hana, Harris, Thomas M
Published in Journal of the American Chemical Society (01.11.1983)
Published in Journal of the American Chemical Society (01.11.1983)
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Journal Article
Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists
Kerwin, James F, Nadzan, Alex M, Kopecka, Hana, Lin, Chun Wel, Miller, Thomas, Witte, David, Burt, Stanley
Published in Journal of medicinal chemistry (01.04.1989)
Published in Journal of medicinal chemistry (01.04.1989)
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Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes
Madar, David J, Kopecka, Hana, Pireh, Daisy, Yong, Hong, Pei, Zhonghua, Li, Xiaofeng, Wiedeman, Paul E, Djuric, Stevan W, Von Geldern, Thomas W, Fickes, Michael G, Bhagavatula, Lakshmi, McDermott, Todd, Wittenberger, Steven, Richards, Steven J, Longenecker, Kenton L, Stewart, Kent D, Lubben, Thomas H, Ballaron, Stephen J, Stashko, Michael A, Long, Michelle A, Wells, Heidi, Zinker, Bradley A, Mika, Amanda K, Beno, David W. A, Kempf-Grote, Anita J, Polakowski, James, Segreti, Jason, Reinhart, Glenn A, Fryer, Ryan M, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
Backes, Bradley J., Longenecker, Kenton, Hamilton, Gregory L., Stewart, Kent, Lai, Chunqiu, Kopecka, Hana, von Geldern, Thomas W., Madar, David J., Pei, Zhonghua, Lubben, Thomas H., Zinker, Bradley A., Tian, Zhenping, Ballaron, Stephen J., Stashko, Michael A., Mika, Amanda K., Beno, David W.A., Kempf-Grote, Anita J., Black-Schaefer, Candace, Sham, Hing L., Trevillyan, James M.
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721
Madar, David J, Kopecka, Hana, Pireh, Daisy, Pease, Jonathan, Pliushchev, Marina, Sciotti, Richard J, Wiedeman, Paul E, Djuric, Stevan W
Published in Tetrahedron letters (28.05.2001)
Published in Tetrahedron letters (28.05.2001)
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2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands
Elliott, Richard L., Kopecka, Hana, Gunn, David E., Lin, Nan-Horng, Garvey, David S., Ryther, Keith B., Holladay, Mark W., Anderson, David J., Campbell, Jeffrey E., Sullivan, James P., Buckley, Michael J., Gunther, Karen L., O'Neill, Alyssa B., Decker, Michael W., Arnerić, Stephen P.
Published in Bioorganic & medicinal chemistry letters (08.10.1996)
Published in Bioorganic & medicinal chemistry letters (08.10.1996)
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Minor Structural Differences in Boc-CCK-4 Derivatives Dictate Affinity and Selectivity for CCK-A and CCK-B Receptors
Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Bianchi, Bruce, Miller, Thomas, Stashko, Michael, Witte, David
Published in Journal of medicinal chemistry (28.03.1997)
Published in Journal of medicinal chemistry (28.03.1997)
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Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases
Mollison, K W, Fey, T A, Gauvin, D M, Sheets, M P, Smith, M L, Pong, M, Krause, R, Miller, L, Or, Y S, Kawai, M, Wagner, R, Wiedeman, P E, Clark, R F, Gunawardana, I W, Rhoades, T A, Henry, C L, Tu, N P, BaMaung, N Y, Kopecka, H, Liu, L, Xie, Q, Lane, B C, Trevillyan, J M, Marsh, K, Luly, J R
Published in Current pharmaceutical design (01.10.1998)
Published in Current pharmaceutical design (01.10.1998)
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Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-A receptor agonists
Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Tufano, Michael D, Bianchi, Bruce R, Miller, Thomas R, Witte, David G, Nadzan, Alex M
Published in Journal of medicinal chemistry (01.09.1991)
Published in Journal of medicinal chemistry (01.09.1991)
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Development of CCK-tetrapeptide analogs as potent and selective CCK-A receptor agonists
Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Craig, Richard, Wagenaar, Frank L, Bianchi, Bruce, Miller, Thomas, Witte, David, Nadzan, Alex M
Published in Journal of medicinal chemistry (01.11.1990)
Published in Journal of medicinal chemistry (01.11.1990)
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Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors
CHUN WELL LIN, SHIOSAKI, K, MILLER, T. R, WITTE, D. G, BIANCHI, B. R, WOLFRAM, C. A. W, KOPECKA, H, CRAIG, R, WAGENAAR, F, NADZAN, A. M
Published in Molecular pharmacology (01.03.1991)
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Published in Molecular pharmacology (01.03.1991)
Journal Article
Tetrapeptide CCK-A Agonists: Effect of Backbone N-Methylations on in vitro and in vivo CCK Activity
Holladay, Mark W, Kopecka, Hana, Miller, Thomas R, Bednarz, Lisa, Nikkel, A. L, Bianchi, Bruce R, Witte, David G, Shiosaki, Kazumi, Lin, Chun Wel
Published in Journal of medicinal chemistry (01.03.1994)
Published in Journal of medicinal chemistry (01.03.1994)
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Evidence that type A CCK receptors facilitate dopamine efflux in rat brain
Vickroy, T W, Bianchi, B R, Kerwin, Jr, J F, Kopecka, H, Nadzan, A M
Published in European journal of pharmacology (02.08.1988)
Published in European journal of pharmacology (02.08.1988)
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Double bond isosteres of the peptide bond: Synthesis and biological activity of cholecystokinin (CCK) C-terminal hexapeptide analogs
Shue, Youe-Kong, Tufano, Michael D., Carrera, George M., Kopecka, Hana, Kuyper, Sharon L., Holladay, Mark W., Wel Lin, Chun, Witte, David G., Miller, Thomas R., Stashko, Mike, Nadzan, Alex M.
Published in Bioorganic & medicinal chemistry (01.09.1993)
Published in Bioorganic & medicinal chemistry (01.09.1993)
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Cholecystokinin (CCK) antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors
Kerwin, James F, Wagenaar, Frank, Kopecka, Hana, Lin, Chun Wel, Miller, Thomas, Witte, David, Stashko, Michael, Nadzan, Alex M
Published in Journal of medicinal chemistry (01.12.1991)
Published in Journal of medicinal chemistry (01.12.1991)
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Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus
Elliott, Richard L, Kopecka, Hana, Bennett, Michael J, Shue, Youe Kong, Craig, Richard, Lin, Chun Wel, Bianchi, Bruce R, Miller, Thomas R, Witte, David G
Published in Journal of medicinal chemistry (01.01.1994)
Published in Journal of medicinal chemistry (01.01.1994)
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