Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
GARCIA, Pablo D, LANGOWSKI, John L, NIU, Xiao-Hong, BASHAM, Stephen, CHAN, Julie, JIANJUN YU, DOYLE, Michael, FEUCHT, Paul, WARNE, Robert, NARBERES, Jamie, TSANG, Tiffany, FRITSCH, Christine, YINGYUN WANG, KAUFFMANN, Audrey, PFISTER, Estelle, DRUECKES, Peter, TRAPPE, Joerg, WILSON, Christopher, WOOSEOK HAN, JIONG LAN, NISHIGUCHI, Gisele, LINDVALL, Mika, BELLAMACINA, Cornelia, MIN CHEN, AYCINENA, J. Alex, ZANG, Richard, HOLASH, Jocelyn, BURGER, Matthew T, CASTILLO, Joseph, FANTON, Christie, ISON, Marjorie, ZAVOROTINSKAYA, Tatiana, YUMIN DAI, JING LU
Published in Clinical cancer research (01.04.2014)
Published in Clinical cancer research (01.04.2014)
Get full text
Journal Article
Identification of N‑(4-((1R,3S,5S)‑3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies
Burger, Matthew T, Nishiguchi, Gisele, Han, Wooseok, Lan, Jiong, Simmons, Robert, Atallah, Gordana, Ding, Yu, Tamez, Victoriano, Zhang, Yanchen, Mathur, Michelle, Muller, Kristine, Bellamacina, Cornelia, Lindvall, Mika K, Zang, Richard, Huh, Kay, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Basham, Steve, Chan, Julie, Ginn, Elaine, Aycinena, Alex, Holash, Jocelyn, Castillo, Joseph, Langowski, John L, Wang, Yingyun, Chen, Min Y, Lambert, Amy, Fritsch, Christine, Kauffmann, Audry, Pfister, Estelle, Vanasse, K. Gary, Garcia, Pablo D
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
Get full text
Journal Article
MgI2-Mediated Ring Expansions of Secondary Methylenecyclopropyl Amides
Lautens, Mark, Han, Wooseok, Liu, Jack Hung-Chang
Published in Journal of the American Chemical Society (09.04.2003)
Published in Journal of the American Chemical Society (09.04.2003)
Get full text
Journal Article
Workspace Force/Acceleration Disturbance Observer for Precise and Safe Motion Control
Han, Wooseok, Yun, Wonbum, Oh, Sehoon
Published in 2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) (01.10.2023)
Published in 2023 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS) (01.10.2023)
Get full text
Conference Proceeding
Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis
Han, Wooseok, Ma, Xiaolei, Balibar, Carl J, Baxter Rath, Christopher M, Benton, Bret, Bermingham, Alun, Casey, Fergal, Chie-Leon, Barbara, Cho, Min-Kyu, Frank, Andreas O, Frommlet, Alexandra, Ho, Chi-Min, Lee, Patrick S, Li, Min, Lingel, Andreas, Ma, Sylvia, Merritt, Hanne, Ornelas, Elizabeth, De Pascale, Gianfranco, Prathapam, Ramadevi, Prosen, Katherine R, Rasper, Dita, Ruzin, Alexey, Sawyer, William S, Shaul, Jacob, Shen, Xiaoyu, Shia, Steven, Steffek, Micah, Subramanian, Sharadha, Vo, Jason, Wang, Feng, Wartchow, Charles, Uehara, Tsuyoshi
Published in Journal of the American Chemical Society (04.03.2020)
Published in Journal of the American Chemical Society (04.03.2020)
Get full text
Journal Article
Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase
Bagdanoff, Jeffrey T., Jain, Rama, Han, Wooseok, Zhu, Shejin, Madiera, Ann-Marie, Lee, Patrick S., Ma, Xiaolei, Poon, Daniel
Published in Bioorganic & medicinal chemistry letters (15.09.2015)
Published in Bioorganic & medicinal chemistry letters (15.09.2015)
Get full text
Journal Article
Synthesis and Structure–Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases
Han, Wooseok, Ding, Yu, Chen, Zheng, Langowski, John L, Bellamacina, Cornelia, Rico, Alice, Nishiguchi, Gisele A, Lan, Jiong, Atallah, Gordana, Lindvall, Mika, Lin, Song, Zang, Richard, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Garcia, Pablo, Burger, Matthew T
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
Get full text
Journal Article
COMPOUND FOR TARGETED PROTEIN DEGRADATION, AND USE THEREOF
KIM, Chulwon, HAN, Wooseok, KI, Dong Hyuk, NAM, Joonwoo, KIM, Eun-Jung, CHOI, Hun-Mi, KIM, Jiyeon
Year of Publication 04.04.2024
Get full text
Year of Publication 04.04.2024
Patent
Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design
Han, Wooseok, Ding, Yu, Xu, Yongjin, Pfister, Keith, Zhu, Shejin, Warne, Bob, Doyle, Mike, Aikawa, Mina, Amiri, Payman, Appleton, Brent, Stuart, Darrin D, Fanidi, Abdallah, Shafer, Cynthia M
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
Get full text
Journal Article
Abstract LB168: A selective, potent, and orally bioavailable CDK7 inhibitor demonstrates superior anti-cancer activity in colorectal cancer models
Park, Heuijoon, Seo, Kyoungwan, Yu, Jihyun, Kim, Jieun, Joo, Min Sung, Kim, Sungeun, Lee, Joonhyung, Lee, Jeonghyeon, Kim, Eun-Jung, Nam, Joonwoo, Han, Wooseok
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Get full text
Journal Article
Abstract 3295: Pharmacological characterization of CYRS1542: A potent and orally available GSPT1 molecular glue degrader for the treatment of neuroendocrine solid cancer with a favorable safety profile
Joo, Min Sung, Lee, JaeYung, Lee, Joonhyung, Kim, Eun-Jung, Song, Seogbeom, Lee, Jeonghyeon, Nam, Joonwoo, Park, Heuijoon, Park, Jaewoo, Kang, Keon Wook, Han, Wooseok
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
Abstract 3313: Discovery of a potent, selective, and orally available small molecule for disruption of the SOS1-RAS interaction
Ki, Dong Hyuk, Yu, Hana, Kim, Donggeon, Jeon, Yeejin, Jo, Seongin, Nam, Joonwoo, Kim, Eun-Jung, Kim, Sungeun, Choi, Hunmi, Kim, Jieun, Yu, Jihyun, Choi, Sungpil, Han, Wooseok
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
GSPT1 NOVEL GSPT1 DEGRADERS AND THEIR USE
HAN WOOSEOK, KIM EUN JUNG, NAM JOONWOO, JOO MIN SUNG, KI DONG HYUK, LEE JAEYUNG
Year of Publication 29.08.2023
Get full text
Year of Publication 29.08.2023
Patent
Abstract 417: Identification of next-generation EGFR degraders to treat non-small cell lung cancer (NSCLC) patients
Ki, Dong Hyuk, Nam, Joonwoo, Kim, Eunjung, Choi, Hunmi, Kim, Chulwon, Kim, Jiyeon, Jin, Jimmy, Kang, Sang-Uk, Han, Wooseok
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Get full text
Journal Article
COMPOUNDS FOR TARGETED PROTEIN DEGRADATION AND USES THEREOF
HAN WOOSEOK, KIM EUN JUNG, NAM JOONWOO, KIM CHULWON, KI DONG HYUK, KIM JIYEON, CHOI HUN MI
Year of Publication 08.04.2024
Get full text
Year of Publication 08.04.2024
Patent
Abstract 5006: Discovery of novel heterobifunctional degraders of mutant EGFR proteins for NSCLCs harboring various EGFR mutations
Ki, Dong Hyuk, Joo, Min Sung, Nam, Joonwoo, Choi, Hunmi, Seo, Kyoungwan, Kim, Eun-Jung, Kim, Jiyeon, Kim, Chulwon, Jin, Jimmy Taiguang, Han, Wooseok
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article
Abstract 1673: Discovery of potent, selective, and orally bioavailable GSPT1 degraders and their pre-clinical anti-tumor activity in acute myeloid leukemia and solid tumors
Joo, Min Sung, Lee, JaeYung, Kim, Eun-Jung, Ki, Dong Hyuk, Choi, Hunmi, Nam, Joonwoo, Park, Jaewoo, Kang, Keon Wook, Han, Wooseok
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article