Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells
Yamamoto, Jun, Han, Qinghong, Inubushi, Sachiko, Sugisawa, Norihiko, Hamada, Kazuyuki, Nishino, Hiroto, Miyake, Kentaro, Kumamoto, Takafumi, Matsuyama, Ryusei, Bouvet, Michael, Endo, Itaru, Hoffman, Robert M.
Published in Biochemical and biophysical research communications (17.12.2020)
Published in Biochemical and biophysical research communications (17.12.2020)
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Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer
Kawaguchi, Kei, Miyake, Kentaro, Han, Qinghong, Li, Shukuan, Tan, Yuying, Igarashi, Kentaro, Kiyuna, Tasuku, Miyake, Masuyo, Higuchi, Takashi, Oshiro, Hiromichi, Zhang, Zhiying, Razmjooei, Sahar, Wangsiricharoen, Sintawat, Bouvet, Michael, Singh, Shree Ram, Unno, Michiaki, Hoffman, Robert M.
Published in Cancer letters (28.09.2018)
Published in Cancer letters (28.09.2018)
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Superiority of [ 11 C]methionine over [ 18 F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer
Kubota, Yutaro, Sato, Toshihiko, Hozumi, Chihiro, Han, Qinghong, Aoki, Yusuke, Masaki, Noriyuki, Obara, Koya, Tsunoda, Takuya, Hoffman, Robert M
Published in International journal of molecular sciences (18.01.2023)
Published in International journal of molecular sciences (18.01.2023)
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Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model
Higuchi, Takashi, Han, Qinghong, Miyake, Kentaro, Oshiro, Hiromichi, Sugisawa, Norihiko, Tan, Yuying, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Igarashi, Kentaro, Bouvet, Michael, Singh, Shree Ram, Tsuchiya, Hiroyuki, Hoffman, Robert M.
Published in Biochemical and biophysical research communications (26.02.2020)
Published in Biochemical and biophysical research communications (26.02.2020)
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The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model
Higuchi, Takashi, Sugisawa, Norihiko, Yamamoto, Jun, Oshiro, Hiromichi, Han, Qinghong, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Igarashi, Kentaro, Tan, Yuying, Kuchipudi, Shreya, Bouvet, Michael, Singh, Shree Ram, Tsuchiya, Hiroyuki, Hoffman, Robert M.
Published in Cancer chemotherapy and pharmacology (01.02.2020)
Published in Cancer chemotherapy and pharmacology (01.02.2020)
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Reversion from Methionine Addiction to Methionine Independence Results in Loss of Tumorigenic Potential of Highly-malignant Lung-cancer Cells
Yamamoto, Jun, Aoki, Yusuke, Han, Qinghong, Sugisawa, Norihiko, Sun, Y U, Hamada, Kazuyuki, Nishino, Hiroto, Inubushi, Sachiko, Miyake, Kentaro, Matsuyama, Ryusei, Bouvet, Michael, Endo, Itaru, Hoffman, Robert M
Published in Anticancer research (01.02.2021)
Published in Anticancer research (01.02.2021)
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Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model
SUGISAWA, NORIHIKO, HAMADA, KAZUYUKI, HAN, QINGHONG, YAMAMOTO, JUN, SUN, YU, NISHINO, HIROTO, KAWAGUCHI, KEI, BOUVET, MICHAEL, UNNO, MICHIAKI, HOFFMAN, ROBERT M.
Published in Anticancer research (01.09.2020)
Published in Anticancer research (01.09.2020)
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Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model
Murakami, Takashi, Li, Shukuan, Han, Qinghong, Tan, Yuying, Kiyuna, Tasuku, Igarashi, Kentaro, Kawaguchi, Kei, Hwang, Ho Kyoung, Miyake, Kentaro, Singh, Arun S, Nelson, Scott D, Dry, Sarah M, Li, Yunfeng, Hiroshima, Yukihiko, Lwin, Thinzar M, DeLong, Jonathan C, Chishima, Takashi, Tanaka, Kuniya, Bouvet, Michael, Endo, Itaru, Eilber, Fritz C, Hoffman, Robert M
Published in Oncotarget (30.05.2017)
Published in Oncotarget (30.05.2017)
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Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation
Aoki, Yusuke, Han, Qinghong, Tome, Yasunori, Yamamoto, Jun, Kubota, Yutaro, Masaki, Noriyuki, Obara, Koya, Hamada, Kazuyuki, Wang, Justin D., Inubushi, Sachiko, Bouvet, Michael, Clarke, Steven G., Nishida, Kotaro, Hoffman, Robert M.
Published in Frontiers in oncology (03.11.2022)
Published in Frontiers in oncology (03.11.2022)
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Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
Kawaguchi, Kei, Han, Qinghong, Li, Shukuan, Tan, Yuying, Igarashi, Kentaro, Murakami, Takashi, Unno, Michiaki, Hoffman, Robert M
Published in Cells (Basel, Switzerland) (02.05.2019)
Published in Cells (Basel, Switzerland) (02.05.2019)
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Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma
Kawaguchi, Kei, Higuchi, Takashi, Li, Shukuan, Han, Qinghong, Tan, Yuying, Igarashi, Kentaro, Zhao, Ming, Miyake, Kentaro, Kiyuna, Tasuku, Miyake, Masuyo, Ohshiro, Hiromichi, Sugisawa, Norihiko, Zhang, Zhiying, Razmjooei, Sahar, Wangsiricharoen, Sintawat, Chmielowski, Bartosz, Nelson, Scott D., Russell, Tara A., Dry, Sarah M., Li, Yunfeng, Eckardt, Mark A., Singh, Arun S., Singh, Shree Ram, Eilber, Fritz C., Unno, Michiaki, Hoffman, Robert M.
Published in Biochemical and biophysical research communications (18.09.2018)
Published in Biochemical and biophysical research communications (18.09.2018)
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Linkage of methionine addiction, histone lysine hypermethylation, and malignancy
Yamamoto, Jun, Inubushi, Sachiko, Han, Qinghong, Tashiro, Yoshihiko, Sugisawa, Norihiko, Hamada, Kazuyuki, Aoki, Yusuke, Miyake, Kentaro, Matsuyama, Ryusei, Bouvet, Michael, Clarke, Steven G., Endo, Itaru, Hoffman, Robert M.
Published in iScience (15.04.2022)
Published in iScience (15.04.2022)
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Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer
Higuchi, Takashi, Han, Qinghong, Sugisawa, Norihiko, Yamamoto, Jun, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Igarashi, Kentaro, Bouvet, Michael, Singh, Shree Ram, Tsuchiya, Hiroyuki, Hoffman, Robert M
Published in Cancer genomics & proteomics (01.03.2021)
Published in Cancer genomics & proteomics (01.03.2021)
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Oral Recombinant Methioninase Prevents Obesity in Mice on a High-fat Diet
Tashiro, Yoshihiko, Han, Qinghong, Tan, Yuying, Sugisawa, Norihiko, Yamamoto, Jun, Nishino, Hiroto, Inubushi, Sachiko, Higuchi, Takashi, Aoki, Takeshi, Murakami, Masahiko, Hoffman, Robert M
Published in In vivo (Athens) (01.03.2020)
Published in In vivo (Athens) (01.03.2020)
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Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation
Aoki, Yusuke, Tome, Yasunori, Han, Qinghong, Yamamoto, Jun, Hamada, Kazuyuki, Masaki, Noriyuki, Bouvet, Michael, Nishida, Kotaro, Hoffman, Robert M.
Published in Biochemistry and biophysics reports (01.12.2021)
Published in Biochemistry and biophysics reports (01.12.2021)
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Oral Recombinant Methioninase Prevents Nonalcoholic Fatty Liver Disease in Mice on a High Fat Diet
Tashiro, Yoshihiko, Han, Qinghong, Tan, Yuying, Sugisawa, Norihiko, Yamamoto, Jun, Nishino, Hiroto, Inubushi, Sachiko, Sun, Y U, Lim, Hyein, Aoki, Takeshi, Murakami, Masahiko, Takahashi, Yoshihisa, Bouvet, Michael, Hoffman, Robert M
Published in In vivo (Athens) (01.05.2020)
Published in In vivo (Athens) (01.05.2020)
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Oral Recombinant Methioninase Inhibits Diabetes Onset in Mice on a High-fat Diet
Tashiro, Yoshihiko, Han, Qinghong, Tan, Yuying, Sugisawa, Norihiko, Yamamoto, Jun, Nishino, Hiroto, Inubushi, Sachiko, Sun, Y U, Zhu, Guangwei, Lim, Hyein, Aoki, Takeshi, Murakami, Masahiko, Bouvet, Michael, Hoffman, Robert M
Published in In vivo (Athens) (01.05.2020)
Published in In vivo (Athens) (01.05.2020)
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Temozolomide and Pazopanib Combined with FOLFOX Regressed a Primary Colorectal Cancer in a Patient-derived Orthotopic Xenograft Mouse Model
Zhu, Guangwei, Zhao, Ming, Han, Qinghong, Tan, Yuying, Sun, Yu, Bouvet, Michael, Clary, Bryan, Singh, Shree Ram, Ye, Jianxin, Hoffman, Robert M.
Published in Translational oncology (01.03.2020)
Published in Translational oncology (01.03.2020)
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Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice
KOKKINAKIS, Demetrius M, HOFFMAN, Robert M, FRENKEL, Eugene P, WICK, Jacquelynn B, QINGHONG HAN, MINGXU XU, YUYING TAN, SCHOLD, S. Clifford
Published in Cancer research (Chicago, Ill.) (15.05.2001)
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Published in Cancer research (Chicago, Ill.) (15.05.2001)
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