Structural basis for GPR40 allosteric agonism and incretin stimulation
Ho, Joseph D., Chau, Betty, Rodgers, Logan, Lu, Frances, Wilbur, Kelly L., Otto, Keith A., Chen, Yanyun, Song, Min, Riley, Jonathan P., Yang, Hsiu-Chiung, Reynolds, Nichole A., Kahl, Steven D., Lewis, Anjana Patel, Groshong, Christopher, Madsen, Russell E., Conners, Kris, Lineswala, Jayana P., Gheyi, Tarun, Saflor, Melbert-Brian Decipulo, Lee, Matthew R., Benach, Jordi, Baker, Kenton A., Montrose-Rafizadeh, Chahrzad, Genin, Michael J., Miller, Anne R., Hamdouchi, Chafiq
Published in Nature communications (25.04.2018)
Published in Nature communications (25.04.2018)
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Journal Article
New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types
Gampala, Silpa, Moon, Hye-ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Mitchell, Dana K., Brewster, Kylee, Mang, Henry, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma H., Rai, Ratan, Mosley, Amber L., Quinney, Sara K., Clapp, D. Wade, Hamdouchi, Chafiq, Wikel, James, Zhang, Chi, Han, Bumsoo, Georgiadis, Millie M., Kelley, Mark R., Fishel, Melissa L.
Published in Pharmacological research (01.03.2024)
Published in Pharmacological research (01.03.2024)
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Delayed Functional Expression of Neuronal Chemokine Receptors Following Focal Nerve Demyelination in the Rat: A Mechanism for the Development of Chronic Sensitization of Peripheral Nociceptors
Bhangoo, Sonia, Ren, Dongjun, Miller, Richard J, Henry, Kenneth J, Lineswala, Jayana, Hamdouchi, Chafiq, Li, Baolin, Monahan, Patrick E, Chan, David M, Ripsch, Matthew S, White, Fletcher A
Published in Molecular pain (12.12.2007)
Published in Molecular pain (12.12.2007)
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2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity
Hamdouchi, Chafiq, de Blas, Jesús, del Prado, Mirian, Gruber, Joseph, Heinz, Beverly A, Vance, Lori
Published in Journal of medicinal chemistry (14.01.1999)
Published in Journal of medicinal chemistry (14.01.1999)
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Journal Article
Novel route to the synthesis of 4-quinolyl isothiocyanates
Zhong, Boyu, Al-Awar, Rima S., Shih, Chuan, Grimes, John H., Vieth, Michal, Hamdouchi, Chafiq
Published in Tetrahedron letters (27.03.2006)
Published in Tetrahedron letters (27.03.2006)
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Journal Article
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines
Hamdouchi, Chafiq, Keyser, Heather, Collins, Elizabeth, Jaramillo, Carlos, De Diego, Jose Eugenio, Spencer, Charles D, Dempsey, Jack Alan, Anderson, Bryan D, Leggett, Tillie, Stamm, Nancy B, Schultz, Richard M, Watkins, Scott A, Cocke, Kim, Lemke, Stephanie, Burke, Teresa F, Beckmann, Richard P, Dixon, Jeffrey T, Gurganus, Thomas M, Rankl, Nancy B, Houck, Keith A, Zhang, Faming, Vieth, Michal, Espinosa, Juan, Timm, David E, Campbell, Robert M, Patel, Bharvin K R, Brooks, Harold B
Published in Molecular cancer therapeutics (01.01.2004)
Published in Molecular cancer therapeutics (01.01.2004)
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Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines
Jaramillo, Carlos, Carretero, Juan Carlos, de Diego, J.Eugenio, del Prado, Miriam, Hamdouchi, Chafiq, Roldán, José Luis, Sánchez-Martı́nez, Concha
Published in Tetrahedron letters (09.12.2002)
Published in Tetrahedron letters (09.12.2002)
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Journal Article
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors
Bellail, Anita C, Jin, Hong Ri, Lo, Ho-Yin, Jung, Sung Han, Hamdouchi, Chafiq, Kim, Daeho, Higgins, Ryan K, Blanck, Maximilian, le Sage, Carlos, Cross, Benedict C S, Li, Jing, Mosley, Amber L, Wijeratne, Aruna B, Jiang, Wen, Ghosh, Manali, Zhao, Yin Quan, Hauck, Paula M, Shekhar, Anantha, Hao, Chunhai
Published in Science translational medicine (13.10.2021)
Published in Science translational medicine (13.10.2021)
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Journal Article
Cloning and functional characterization of the rabbit C-C chemokine receptor 2
Lu, Deshun, Yuan, Xiu-juan, Evans, Jr, Robert J, Pappas, Amy T, Wang, He, Su, Eric W, Hamdouchi, Chafiq, Venkataraman, Chandrasekar
Published in BMC immunology (07.07.2005)
Published in BMC immunology (07.07.2005)
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Journal Article
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)
Hamdouchi, Chafiq, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, Eessalu, Thomas E, Ficorilli, James V, Marcelo, Marialuisa C, Otto, Keith A, Wilbur, Kelly L, Lineswala, Jayana P, Piper, Jared L, Coffey, D. Scott, Sweetana, Stephanie A, Haas, Joseph V, Brooks, Dawn A, Pratt, Edward J, Belin, Ruth M, Deeg, Mark A, Ma, Xiaosu, Cannady, Ellen A, Johnson, Jason T, Yumibe, Nathan P, Chen, Qi, Maiti, Pranab, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Reifel Miller, Anne
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Journal Article
3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism
Gehlert, Donald R, Cippitelli, Andrea, Thorsell, Annika, Le, Anh Dzung, Hipskind, Philip A, Hamdouchi, Chafiq, Lu, Jianliang, Hembre, Erik J, Cramer, Jeffrey, Song, Min, McKinzie, David, Morin, Michelle, Ciccocioppo, Roberto, Heilig, Markus
Published in The Journal of neuroscience (07.03.2007)
Published in The Journal of neuroscience (07.03.2007)
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Journal Article
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus
Hamdouchi, Chafiq, Maiti, Pranab, Warshawsky, Alan M, DeBaillie, Amy C, Otto, Keith A, Wilbur, Kelly L, Kahl, Steven D, Patel Lewis, Anjana, Cardona, Guemalli R, Zink, Richard W, Chen, Keyue, CR, Siddaramaiah, Lineswala, Jayana P, Neathery, Grace L, Bouaichi, Cecilia, Diseroad, Benjamin A, Campbell, Alison N, Sweetana, Stephanie A, Adams, Lisa A, Cabrera, Over, Ma, Xiaosu, Yumibe, Nathan P, Montrose-Rafizadeh, Chahrzad, Chen, Yanyun, Miller, Anne Reifel
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Abstract C129: Development of new increased potency Ref-1/APE1 targeted inhibitors that show promise for clinical applications against solid tumors
Gampala, Silpa, Moon, Hye-Ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma, Rai, Ratan, Mosley, Amber L, Georgiadis, Millie M, Han, Bumsoo, Zhang, Chi, Hamdouchi, Chafiq, Wikel, James, Kelley, Mark R, Fishel, Melissa L
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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