Synthesis and Structure−Activity Relationships of Soluble 7-Substituted 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridin-2-amines and Related Ureas as Dual Inhibitors of the Fibroblast Growth Factor Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinases
Thompson, Andrew M, Delaney, Amy M, Hamby, James M, Schroeder, Mel C, Spoon, Teresa A, Crean, Sheila M, Showalter, H. D. Hollis, Denny, William A
Published in Journal of medicinal chemistry (14.07.2005)
Published in Journal of medicinal chemistry (14.07.2005)
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Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain
Mohammadi, Moosa, Froum, Scott, Hamby, James M., Schroeder, Mel C., Panek, Robert L., Lu, Gina H., Eliseenkova, Anna V., Green, David, Schlessinger, Joseph, Hubbard, Stevan R.
Published in The EMBO journal (15.10.1998)
Published in The EMBO journal (15.10.1998)
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Development of a Binding Model to Protein Tyrosine Kinases for Substituted Pyrido[2,3-d]pyrimidine Inhibitors
Trumpp-Kallmeyer, Susanne, Rubin, J. Ronald, Humblet, Christine, Hamby, James M, Hollis Showalter, H. D
Published in Journal of medicinal chemistry (21.05.1998)
Published in Journal of medicinal chemistry (21.05.1998)
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In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor
Panek, R L, Lu, G H, Klutchko, S R, Batley, B L, Dahring, T K, Hamby, J M, Hallak, H, Doherty, A M, Keiser, J A
Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor
Palmer, Brian D, Smaill, Jeff B, Boyd, Maruta, Boschelli, Diane H, Doherty, Annette M, Hamby, James M, Khatana, Sonya S, Kramer, James B, Kraker, Alan J, Panek, Robert L, Lu, Gina H, Dahring, Tawny K, Winters, R. Thomas, Showalter, H. D. Hollis, Denny, William A
Published in Journal of medicinal chemistry (31.12.1998)
Published in Journal of medicinal chemistry (31.12.1998)
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Discovery and structure-activity studies of a novel series of pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors
Connolly, Cleo J.C., Hamby, James M., Schroeder, Mel C., Barvian, Mark, Lu, Gina H., Panek, Robert L., Amar, Aneesa, Shen, Cindy, Kraker, Alan J., Fry, David W., Klohs, Wayne D., Doherty, Annette M.
Published in Bioorganic & medicinal chemistry letters (23.09.1997)
Published in Bioorganic & medicinal chemistry letters (23.09.1997)
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Inhibition of Growth Factor-Mediated Tyrosine Phosphorylation in Vascular Smooth Muscle by PD 089828, a New Synthetic Protein Tyrosine Kinase Inhibitor
Dahring, T K, Lu, G H, Hamby, J M, Batley, B L, Kraker, A J, Panek, R L
Published in The Journal of pharmacology and experimental therapeutics (01.06.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.06.1997)
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INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR
Batley, Brian L, Doherty, Annette M, Hamby, James M, Lu, Gina H, Keller, Paul, Dahring, Tawny K, Hwang, Ok, Crickard, Kent, Panek, Robert L
Published in Life sciences (1973) (1998)
Published in Life sciences (1973) (1998)
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Design and Synthesis of Renin Inhibitors: Incorporation of Transition-State Isostere Side Chains That Span from the S1 to the S3 Binding Pockets and Examination of P3-Modified Renin Inhibitors
Shahripour, Aurash, Kaltenbronn, James S, Lunney, Elizabeth A, Steinbaugh, Bruce A, Hamby, James M, Hamilton, Harriet W, Sawyer, Tomi K, Humblet, Christine, Doherty, Annette M
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists
Edmunds, Jeremy J, Klutchko, Sylvester, Hamby, James M, Bunker, Amy M, Connolly, Cleo J. C, Winters, R. Thomas, Quin, John, Sircar, Ila, Hodges, John C
Published in Journal of medicinal chemistry (01.09.1995)
Published in Journal of medicinal chemistry (01.09.1995)
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Renin inhibitors containing .alpha.-heteroatom amino acids as P2 residues
Repine, Joseph T, Kaltenbronn, James S, Doherty, Annette M, Hamby, James M, Himmelsbach, Richard J, Kornberg, Brian E, Taylor, Michael D, Lunney, ELizabeth A, Humblet, Christine
Published in Journal of medicinal chemistry (01.03.1992)
Published in Journal of medicinal chemistry (01.03.1992)
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Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogs
Taylor, Edward C, Hamby, James M, Shih, Chuan, Grindey, Gerald B, Rinzel, Sharon M, Beardsley, G. Peter, Moran, Richard G
Published in Journal of medicinal chemistry (01.07.1989)
Published in Journal of medicinal chemistry (01.07.1989)
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