Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes
Hallakou‐Bozec, Sophie, Vial, Guillaume, Kergoat, Micheline, Fouqueray, Pascale, Bolze, Sébastien, Borel, Anne‐Laure, Fontaine, Eric, Moller, David E.
Published in Diabetes, obesity & metabolism (01.03.2021)
Published in Diabetes, obesity & metabolism (01.03.2021)
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Imeglimin preserves islet β‐cell mass in Type 2 diabetic ZDF rats
Hallakou‐Bozec, Sophie, Kergoat, Micheline, Moller, David E., Bolze, Sébastien
Published in Endocrinology, diabetes & metabolism (01.04.2021)
Published in Endocrinology, diabetes & metabolism (01.04.2021)
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Therapeutic potential of deuterium‐stabilized (R)‐pioglitazone—PXL065—for X‐linked adrenoleukodystrophy
Monternier, Pierre‐Axel, Singh, Jaspreet, Parasar, Parveen, Theurey, Pierre, DeWitt, Sheila, Jacques, Vincent, Klett, Eric, Kaur, Navtej, Nagaraja, Tavarekere N., Moller, David E., Hallakou‐Bozec, Sophie
Published in Journal of inherited metabolic disease (01.07.2022)
Published in Journal of inherited metabolic disease (01.07.2022)
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Phase 2 trial with imeglimin in patients with Type 2 diabetes indicates effects on insulin secretion and sensitivity
Theurey, Pierre, Thang, Carole, Pirags, Valdis, Mari, Andrea, Pacini, Giovanni, Bolze, Sébastien, Hallakou‐Bozec, Sophie, Fouqueray, Pascale
Published in Endocrinology, diabetes & metabolism (01.11.2022)
Published in Endocrinology, diabetes & metabolism (01.11.2022)
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Journal Article
Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis
Gluais‐Dagorn, Pascale, Foretz, Marc, Steinberg, Gregory R., Batchuluun, Battsetseg, Zawistowska‐Deniziak, Anna, Lambooij, Joost M., Guigas, Bruno, Carling, David, Monternier, Pierre‐Axel, Moller, David E., Bolze, Sebastien, Hallakou‐Bozec, Sophie
Published in Hepatology communications (01.01.2022)
Published in Hepatology communications (01.01.2022)
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Reduced lactic acidosis risk with Imeglimin: Comparison with Metformin
Theurey, Pierre, Vial, Guillaume, Fontaine, Eric, Monternier, Pierre‐Axel, Fouqueray, Pascale, Bolze, Sébastien, Moller, David E., Hallakou‐Bozec, Sophie
Published in Physiological reports (01.03.2022)
Published in Physiological reports (01.03.2022)
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Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity
Jacques, Vincent, Bolze, Sébastien, Hallakou‐Bozec, Sophie, Czarnik, Anthony W., Divakaruni, Ajit S., Fouqueray, Pascale, Murphy, Anne N., Van der Ploeg, Lex H.T., DeWitt, Sheila
Published in Hepatology communications (01.08.2021)
Published in Hepatology communications (01.08.2021)
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Journal Article
Short‐and long‐term administration of imeglimin counters cardiorenal dysfunction in a rat model of metabolic syndrome
Lachaux, Marianne, Soulié, Matthieu, Hamzaoui, Mouad, Bailly, Anaëlle, Nicol, Lionel, Rémy‐Jouet, Isabelle, Renet, Sylvanie, Vendeville, Cathy, Gluais‐Dagorn, Pascale, Hallakou‐Bozec, Sophie, Monteil, Christelle, Richard, Vincent, Mulder, Paul
Published in Endocrinology, diabetes & metabolism (01.07.2020)
Published in Endocrinology, diabetes & metabolism (01.07.2020)
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Journal Article
Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrial function in liver of a high-fat, high-sucrose diet mice model
Vial, Guillaume, Chauvin, Marie-Agnès, Bendridi, Nadia, Durand, Annie, Meugnier, Emmanuelle, Madec, Anne-Marie, Bernoud-Hubac, Nathalie, Pais de Barros, Jean-Paul, Fontaine, Éric, Acquaviva, Cécile, Hallakou-Bozec, Sophie, Bolze, Sébastien, Vidal, Hubert, Rieusset, Jennifer
Published in Diabetes (New York, N.Y.) (01.06.2015)
Published in Diabetes (New York, N.Y.) (01.06.2015)
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Journal Article
Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents
Perry, Rachel J, Cardone, Rebecca L, Petersen, Max C, Zhang, Dongyan, Fouqueray, Pascale, Hallakou-Bozec, Sophie, Bolze, Sébastien, Shulman, Gerald I, Petersen, Kitt Falk, Kibbey, Richard G
Published in American journal of physiology: endocrinology and metabolism (01.08.2016)
Published in American journal of physiology: endocrinology and metabolism (01.08.2016)
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티에노피리돈 유도체의 1수화물 칼륨염 및 이의 제조 방법
BOLZE SEBASTIEN, NAVARRE LAURE, ARICAN DENIZ, O'SULLIVAN ANTHONY, HALLAKOU BOZEC SOPHIE, LANZ MARC
Year of Publication 01.07.2021
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Year of Publication 01.07.2021
Patent
THIENOPYRIDONE DERIVATIVES AS AMP-ACTIVATED PROTEIN KINASE (AMPK) ACTIVATORS
CRAVO DANIEL, LEPIFRE FRANCK, HALLAKOU BOZEC SOPHIE, CHARON CHRISTINE
Year of Publication 06.04.2016
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Year of Publication 06.04.2016
Patent
MO019: Preclinical Efficacy of Direct AMPK Activation with a Novel Small Molecule–PXL770–For the Treatment of Autosomal Dominant Polycystic Kidney Disease
Gluais Dagorn, Pascale, Buchholz, Bjoern, Bange, Hester, Blockken, Laura, Moller, David E, Hallakou-Bozec, Sophie
Published in Nephrology, dialysis, transplantation (03.05.2022)
Published in Nephrology, dialysis, transplantation (03.05.2022)
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Journal Article
Evaluation of PXL065 – deuterium-stabilized (R)-pioglitazone in patients with NASH: A phase II randomized placebo-controlled trial (DESTINY-1)
Harrison, Stephen A., Thang, Carole, Bolze, Sébastien, Dewitt, Sheila, Hallakou-Bozec, Sophie, Dubourg, Julie, Bedossa, Pierre, Cusi, Kenneth, Ratziu, Vlad, Grouin, Jean-Marie, Moller, David E., Fouqueray, Pascale
Published in Journal of hepatology (01.05.2023)
Published in Journal of hepatology (01.05.2023)
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Journal Article
A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease
Dagorn, Pascale Gluais, Buchholz, Bjoern, Kraus, Andre, Batchuluun, Battsetseg, Bange, Hester, Blockken, Laura, Steinberg, Gregory R., Moller, David E., Hallakou-Bozec, Sophie
Published in Kidney international (01.05.2023)
Published in Kidney international (01.05.2023)
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