Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors
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Published in Science (American Association for the Advancement of Science) (11.09.1998)
Published in Science (American Association for the Advancement of Science) (11.09.1998)
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Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Identification of Leu276 of the S1P1 Receptor and Phe263 of the S1P3 Receptor in Interaction with Receptor Specific Agonists by Molecular Modeling, Site-Directed Mutagenesis, and Affinity Studies
Deng, Qiaolin, Clemas, Joseph A, Chrebet, Gary, Fischer, Paul, Hale, Jeffrey J, Li, Zhen, Mills, Sander G, Bergstrom, James, Mandala, Suzanne, Mosley, Ralph, Parent, Stephen A
Published in Molecular pharmacology (01.03.2007)
Published in Molecular pharmacology (01.03.2007)
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The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
Graham, Thomas H., Shen, Hong C., Liu, Wensheng, Xiong, Yusheng, Verras, Andreas, Bleasby, Kelly, Bhatt, Urmi R., Chabin, Renee M., Chen, Dunlu, Chen, Qing, Garcia-Calvo, Margarita, Geissler, Wayne M., He, Huaibing, Lassman, Michael E., Shen, Zhu, Tong, Xinchun, Tung, Elaine C., Xie, Dan, Xu, Suoyu, Colletti, Steven L., Tata, James R., Hale, Jeffrey J., Pinto, Shirly, Shen, Dong-Ming
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720
Hale, Jeffrey J., Neway, William, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Koo, Gloria C., Koprak, Sam L., Jackson, Jesse J., Rosen, Hugh, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P 1) receptor
Vachal, Petr, Toth, Leslie M., Hale, Jeffrey J., Yan, Lin, Mills, Sander G., Chrebet, Gary L., Koehane, Carol A., Hajdu, Richard, Milligan, James A., Rosenbach, Mark J., Mandala, Suzanne
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
Hale, Jeffrey J, Mills, Sander G, MacCoss, Malcolm, Finke, Paul E, Cascieri, Margaret A, Sadowski, Sharon, Ber, Elzbieta, Chicchi, Gary G, Kurtz, Marc, Metzger, Joseph, Eiermann, George, Tsou, Nancy N, Tattersall, F. David, Rupniak, Nadia M. J, Williams, Angela R, Rycroft, Wayne, Hargreaves, Richard, MacIntyre, D. Euan
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
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Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720
Hale, Jeffrey J., Yan, Lin, Neway, William E., Hajdu, Richard, Bergstrom, James D., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary L., Thornton, Rosemary A., Card, Deborah, Rosenbach, Mark, HughRosen, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry (15.09.2004)
Published in Bioorganic & medicinal chemistry (15.09.2004)
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Synthesis and evaluation of N-[(1 S,2 S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists
Du, Wu, Jewell, James P., Lin, Linus S., Colandrea, Vincent J., Xiao, Jing C., Lao, Julie, Shen, Chun-Pyn, Bateman, Thomas J., Reddy, Vijay B.G., Ha, Sookhee N., Shah, Shrenik K., Fong, Tung M., Hale, Jeffrey J., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Discovery of N‑[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia
Debenham, John S, Madsen-Duggan, Christina, Clements, Matthew J, Walsh, Thomas F, Kuethe, Jeffrey T, Reibarkh, Mikhail, Salowe, Scott P, Sonatore, Lisa M, Hajdu, Richard, Milligan, James A, Visco, Denise M, Zhou, Dan, Lingham, Russell B, Stickens, Dominique, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Pang, Jianmei, Miller, Randy R, Sherer, Edward C, Hale, Jeffrey J
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia
Vachal, Petr, Miao, Shouwu, Pierce, Joan M, Guiadeen, Deodial, Colandrea, Vincent J, Wyvratt, Matthew J, Salowe, Scott P, Sonatore, Lisa M, Milligan, James A, Hajdu, Richard, Gollapudi, Anantha, Keohane, Carol A, Lingham, Russell B, Mandala, Suzanne M, DeMartino, Julie A, Tong, Xinchun, Wolff, Michael, Steinhuebel, Dietrich, Kieczykowski, Gerard R, Fleitz, Fred J, Chapman, Kevin, Athanasopoulos, John, Adam, Gregory, Akyuz, Can D, Jena, Dhirendra K, Lusen, Jeffrey W, Meng, Juncai, Stein, Benjamin D, Xia, Lei, Sherer, Edward C, Hale, Jeffrey J
Published in Journal of medicinal chemistry (12.04.2012)
Published in Journal of medicinal chemistry (12.04.2012)
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Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
Lin, Songnian, Malkani, Sunita, Lombardo, Matthew, Yang, Lihu, Mills, Sander G., Chapman, Kevin, Thompson, James E., Zhang, Wen Xiao, Wang, Ruixiu, Cubbon, Rose M., O’Neill, Edward A., Hale, Jeffrey J.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Discovery of benzamides as potent human β3 adrenergic receptor agonists
Zhu, Cheng, Kar, Nam F., Li, Bing, Costa, Melissa, Dingley, Karen H., Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda L., Li, Xiaofang, Miller, Randy R., Salituro, Gino M., Struthers, Mary, Weber, Ann E., Hale, Jeffrey J., Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
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Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia
Liu, Ping, Wang, Liping, DuBois, Byron G, Colandrea, Vincent J, Liu, Rongqiang, Cai, Jiaqiang, Du, Xiaoxing, Quan, Weiguo, Morris, William, Bai, Jianwu, Bishwokarma, Bimjhana, Cheng, Mangeng, Piesvaux, Jennifer, Ray, Kallol, Alpert, Carla, Chiu, Chi-Sung, Zielstorff, Mark, Metzger, Joseph M, Yang, Liming, Leung, Dennis, Alleyne, Candice, Vincent, Stella H, Pucci, Vincenzo, Li, Xiaofang, Crespo, Alejandro, Stickens, Dominique, Hale, Jeffrey J, Ujjainwalla, Feroze, Sinz, Christopher J
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
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Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder
Harper, Bart H., Wang, Liping, Zhu, Cheng, Kar, Nam F., Li, Bing, Moyes, Christopher R., Goble, Stephen D., Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda, Li, Xiaofang, Miller, Randy R., Nagabukuro, Hiroshi, Salituro, Gino M., Smith, Sean, Struthers, Mary, Hale, Jeffrey J., Edmondson, Scott D., Berger, Richard
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors
Graham, Thomas H., Shu, Min, Verras, Andreas, Chen, Qing, Garcia-Calvo, Margarita, Li, Xiaohua, Lisnock, JeanMarie, Tong, Xinchun, Tung, Elaine C., Wiltsie, Judyann, Hale, Jeffrey J., Pinto, Shirly, Shen, Dong-Ming
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
Published in Bioorganic & medicinal chemistry letters (01.04.2014)
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Journal Article
Investigation of piperazine benzamides as human β 3 adrenergic receptor agonists for the treatment of overactive bladder
Harper, Bart H, Wang, Liping, Zhu, Cheng, Kar, Nam F, Li, Bing, Moyes, Christopher R, Goble, Stephen D, Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N, Hurley, Amanda, Li, Xiaofang, Miller, Randy R, Nagabukuro, Hiroshi, Salituro, Gino M, Smith, Sean, Struthers, Mary, Hale, Jeffrey J, Edmondson, Scott D, Berger, Richard
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor
Chen, Richard Z., Frassetto, Andrea, Lao, Julie Z., Huang, Ruey-Ruey C., Xiao, Jing C., Clements, Matthew J., Walsh, Thomas F., Hale, Jeffrey J., Wang, Junying, Tong, Xinchun, Fong, Tung M.
Published in European journal of pharmacology (28.04.2008)
Published in European journal of pharmacology (28.04.2008)
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Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors
Debenham, John S., Graham, Thomas H., Verras, Andreas, Zhang, Yong, Clements, Matthew J., Kuethe, Jeffrey T., Madsen-Duggan, Christina, Liu, Wensheng, Bhatt, Urmi R., Chen, Dunlu, Chen, Qing, Garcia-Calvo, Margarita, Geissler, Wayne M., He, Huaibing, Li, Xiaohua, Lisnock, JeanMarie, Shen, Zhu, Tong, Xinchun, Tung, Elaine C., Wiltsie, Judyann, Xu, Suoyu, Hale, Jeffrey J., Pinto, Shirly, Shen, Dong-Ming
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
Published in Bioorganic & medicinal chemistry letters (01.12.2013)
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