Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Oberst, Andrew, Dillon, Christopher P., Weinlich, Ricardo, McCormick, Laura L., Fitzgerald, Patrick, Pop, Cristina, Hakem, Razq, Salvesen, Guy S., Green, Douglas R.
Published in Nature (London) (17.03.2011)
Published in Nature (London) (17.03.2011)
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The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
Alvarez-Diaz, Silvia, Dillon, Christopher P., Lalaoui, Najoua, Tanzer, Maria C., Rodriguez, Diego A., Lin, Ann, Lebois, Marion, Hakem, Razq, Josefsson, Emma C., O’Reilly, Lorraine A., Silke, John, Alexander, Warren S., Green, Douglas R., Strasser, Andreas
Published in Immunity (Cambridge, Mass.) (20.09.2016)
Published in Immunity (Cambridge, Mass.) (20.09.2016)
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Modification of BRCA1-associated breast cancer risk by HMMR overexpression
Mateo, Francesca, He, Zhengcheng, Mei, Lin, de Garibay, Gorka Ruiz, Herranz, Carmen, García, Nadia, Lorentzian, Amanda, Baiges, Alexandra, Blommaert, Eline, Gómez, Antonio, Mirallas, Oriol, Garrido-Utrilla, Anna, Palomero, Luis, Espín, Roderic, Extremera, Ana I., Soler-Monsó, M. Teresa, Petit, Anna, Li, Rong, Brunet, Joan, Chen, Ke, Tan, Susanna, Eaves, Connie J., McCloskey, Curtis, Hakem, Razq, Khokha, Rama, Lange, Philipp F., Lázaro, Conxi, Maxwell, Christopher A., Pujana, Miquel Angel
Published in Nature communications (07.04.2022)
Published in Nature communications (07.04.2022)
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The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
D'Cruz, Akshay A, Speir, Mary, Bliss-Moreau, Meghan, Dietrich, Sylvia, Wang, Shu, Chen, Alyce A, Gavillet, Mathilde, Al-Obeidi, Arshed, Lawlor, Kate E, Vince, James E, Kelliher, Michelle A, Hakem, Razq, Pasparakis, Manolis, Williams, David A, Ericsson, Maria, Croker, Ben A
Published in Science signaling (04.09.2018)
Published in Science signaling (04.09.2018)
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Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia
Barghout, Samir H., Patel, Parasvi S., Wang, Xiaoming, Xu, G. Wei, Kavanagh, Simon, Halgas, Ondrej, Zarabi, Sara F., Gronda, Marcela, Hurren, Rose, Jeyaraju, Danny V., MacLean, Neil, Brennan, Shawn, Hyer, Marc L., Berger, Allison, Traore, Tary, Milhollen, Michael, Smith, Adam C., Minden, Mark D., Pai, Emil F., Hakem, Razq, Schimmer, Aaron D.
Published in Leukemia (01.01.2019)
Published in Leukemia (01.01.2019)
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RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation
Vucur, Mihael, Reisinger, Florian, Gautheron, Jérémie, Janssen, Joern, Roderburg, Christoph, Cardenas, David Vargas, Kreggenwinkel, Karina, Koppe, Christiane, Hammerich, Linda, Hakem, Razq, Unger, Kristian, Weber, Achim, Gassler, Nikolaus, Luedde, Mark, Frey, Norbert, Neumann, Ulf Peter, Tacke, Frank, Trautwein, Christian, Heikenwalder, Mathias, Luedde, Tom
Published in Cell reports (Cambridge) (29.08.2013)
Published in Cell reports (Cambridge) (29.08.2013)
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Immune Cell Associations with Cancer Risk
Palomero, Luis, Galván-Femenía, Ivan, de Cid, Rafael, Espín, Roderic, Barnes, Daniel R., CIMBA, Blommaert, Eline, Gil-Gil, Miguel, Falo, Catalina, Stradella, Agostina, Ouchi, Dan, Roso-Llorach, Albert, Violan, Concepció, Peña-Chilet, María, Dopazo, Joaquín, Extremera, Ana Isabel, García-Valero, Mar, Herranz, Carmen, Mateo, Francesca, Mereu, Elisabetta, Beesley, Jonathan, Chenevix-Trench, Georgia, Roux, Cecilia, Mak, Tak, Brunet, Joan, Hakem, Razq, Gorrini, Chiara, Antoniou, Antonis C., Lázaro, Conxi, Pujana, Miquel Angel
Published in iScience (24.07.2020)
Published in iScience (24.07.2020)
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Nucleolar RNA polymerase II drives ribosome biogenesis
Abraham, Karan J., Khosraviani, Negin, Chan, Janet N. Y., Gorthi, Aparna, Samman, Anas, Zhao, Dorothy Y., Wang, Miling, Bokros, Michael, Vidya, Elva, Ostrowski, Lauren A., Oshidari, Roxanne, Pietrobon, Violena, Patel, Parasvi S., Algouneh, Arash, Singhania, Rajat, Liu, Yupeng, Yerlici, V. Talya, De Carvalho, Daniel D., Ohh, Michael, Dickson, Brendan C., Hakem, Razq, Greenblatt, Jack F., Lee, Stephen, Bishop, Alexander J. R., Mekhail, Karim
Published in Nature (London) (10.09.2020)
Published in Nature (London) (10.09.2020)
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Leukemia Stem Cells Demonstrate Increased DNA Damage Repair and Chemoresistance in Acute Myeloid Leukemia
Egan, Grace, Thomas, Geethu Emily, Patel, Parasvi, Hurren, Rose, MacLean, Neil, Hakem, Razq, Schimmer, Aaron D
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML
Egan, Grace, Thomas, G.E., Patel, Parasvi, Voisin, Veronique, Hurren, Rose, MacLean, Neil, Hakem, Razq, Schimmer, Aaron D.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness
Thomas, Geethu Emily, Egan, Grace, García-Prat, Laura, Botham, Aaron, Voisin, Veronique, Patel, Parasvi S., Hoff, Fieke W., Chin, Jordan, Nachmias, Boaz, Kaufmann, Kerstin B., Khan, Dilshad H., Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, MacLean, Neil, O’Brien, Cristiana, Singh, Rashim P., Jones, Courtney L., Harding, Shane M., Raught, Brian, Arruda, Andrea, Minden, Mark D., Bader, Gary D., Hakem, Razq, Kornblau, Steve, Dick, John E., Schimmer, Aaron D.
Published in Nature cell biology (01.06.2022)
Published in Nature cell biology (01.06.2022)
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Reducing protein oxidation reverses lung fibrosis
Anathy, Vikas, Lahue, Karolyn G., Chapman, David G., Chia, Shi B., Casey, Dylan T., Aboushousha, Reem, van der Velden, Jos L. J., Elko, Evan, Hoffman, Sidra M., McMillan, David H., Jones, Jane T., Nolin, James D., Abdalla, Sarah, Schneider, Robert, Seward, David J., Roberson, Elle C., Liptak, Matthew D., Cousins, Morgan E., Butnor, Kelly J., Taatjes, Douglas. J., Budd, Ralph C., Irvin, Charles G., Ho, Ye-Shih, Hakem, Razq, Brown, Kevin K., Matsui, Reiko, Bachschmid, Markus M., Gomez, Jose L., Kaminski, Naftali, van der Vliet, Albert, Janssen-Heininger, Yvonne M. W.
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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Abstract 3784: The metabolic enzyme Hexokinase 2 localizes to the nucleus and regulates stemness in AML through a kinase independent mechanism
Egan, Grace, Thomas, Geethu E., Patel, Parasvi S., Chin, Jordan, Botham, Aaron, Hurren, Rose, MacLean, Neil, Hakem, Razq, Schimmer, Aaron D.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis
Li, Li, Guturi, Kiran Kumar Naidu, Gautreau, Brandon, Patel, Parasvi S, Saad, Amine, Morii, Mayako, Mateo, Francesca, Palomero, Luis, Barbour, Haithem, Gomez, Antonio, Ng, Deborah, Kotlyar, Max, Pastrello, Chiara, Jackson, Hartland W, Khokha, Rama, Jurisica, Igor, Affar, El Bachir, Raught, Brian, Sanchez, Otto, Alaoui-Jamali, Moulay, Pujana, Miguel A, Hakem, Anne, Hakem, Razq
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
Speir, Mary, Nowell, Cameron J., Chen, Alyce A., O’Donnell, Joanne A., Shamie, Isaac S., Lakin, Paul R., D’Cruz, Akshay A., Braun, Roman O., Babon, Jeff J., Lewis, Rowena S., Bliss-Moreau, Meghan, Shlomovitz, Inbar, Wang, Shu, Cengia, Louise H., Stoica, Anca I., Hakem, Razq, Kelliher, Michelle A., O’Reilly, Lorraine A., Patsiouras, Heather, Lawlor, Kate E., Weller, Edie, Lewis, Nathan E., Roberts, Andrew W., Gerlic, Motti, Croker, Ben A.
Published in Nature immunology (01.01.2020)
Published in Nature immunology (01.01.2020)
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Journal Article
Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis
Li, Li, Guturi, Kiran Kumar Naidu, Gautreau, Brandon, Patel, Parasvi S., Saad, Amine, Morii, Mayako, Mateo, Francesca, Palomero, Luis, Barbour, Haithem, Gomez, Antonio, Ng, Deborah, Kotlyar, Max, Pastrello, Chiara, Jackson, Hartland W., Khokha, Rama, Jurisica, Igor, Affar, El Bachir, Raught, Brian, Sanchez, Otto, Alaoui-Jamali, Moulay, Pujana, Miguel A., Hakem, Anne, Hakem, Razq
Published in The Journal of clinical investigation (01.07.2021)
Published in The Journal of clinical investigation (01.07.2021)
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Journal Article
Ptpn6 inhibits Caspase-8- and Ripk3/Mlkl-dependent inflammation
Croker, Ben A, Speir, Mary, Nowell, Cameron J, Chen, Alyce A, O’Donnell, Joanne A, D’Cruz, Akshay A, Bliss-Moreau, Meghan, Wang, Shu, Kelliher, Michelle A, Hakem, Razq, Gerlic, Motti
Published in The Journal of immunology (1950) (01.05.2019)
Published in The Journal of immunology (1950) (01.05.2019)
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Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl
D'Cruz, Akshay A, Speir, Mary, Bliss-Moreau, Meghan, Dietrich, Sylvia, Chen, Alyce A, Gavillet, Mathilde, Lawlor, Kate E, Vince, James E, Kelliher, Michelle, Hakem, Razq, Pasparakis, Manolis, Williams, David A, Ericsson, Maria, Croker, Ben A
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
Kaufmann, Thomas, Jost, Philipp J., Pellegrini, Marc, Puthalakath, Hamsa, Gugasyan, Raffi, Gerondakis, Steve, Cretney, Erika, Smyth, Mark J., Silke, John, Hakem, Razq, Bouillet, Philippe, Mak, Tak W., Dixit, Vishva M., Strasser, Andreas
Published in Immunity (Cambridge, Mass.) (16.01.2009)
Published in Immunity (Cambridge, Mass.) (16.01.2009)
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