Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
Mares, Alina, Miah, Afjal H, Smith, Ian E D, Rackham, Mark, Thawani, Aditya R, Cryan, Jenni, Haile, Pamela A, Votta, Bartholomew J, Beal, Allison M, Capriotti, Carol, Reilly, Michael A, Fisher, Don T, Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T, Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B, Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D
Published in Communications biology (20.03.2020)
Published in Communications biology (20.03.2020)
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Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway
Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Zeng, Xin, Montoute, Monica N, Chordia, Tushar, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Haile, Pamela A, Yu, Jong, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John
Published in PloS one (01.08.2013)
Published in PloS one (01.08.2013)
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Enantioselective Total Synthesis of Brevetoxin A: Unified Strategy for the B, E, G, and J Subunits
Crimmins, Michael T., Ellis, J. Michael, Emmitte, Kyle A., Haile, Pamela A., McDougall, Patrick J., Parrish, Jonathan D., Zuccarello, J. Lucas
Published in Chemistry : a European journal (14.09.2009)
Published in Chemistry : a European journal (14.09.2009)
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Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway
Rickard, David J, Sehon, Clark A, Kasparcova, Viera, Kallal, Lorena A, Haile, Pamela A, Zeng, Xin, Montoute, Monica N, Poore, Derek D, Li, Hu, Wu, Zining, Eidam, Patrick M, Emery, John G, Marquis, Robert W, Gough, Peter J, Bertin, John
Published in PloS one (07.05.2014)
Published in PloS one (07.05.2014)
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Optimization of a Series of RIPK2 PROTACs
Miah, Afjal H, Smith, Ian E. D, Rackham, Mark, Mares, Alina, Thawani, Aditya R, Nagilla, Rakesh, Haile, Pamela A, Votta, Bartholomew J, Gordon, Laurie J, Watt, Gillian, Denyer, Jane, Fisher, Don T, Dace, Phoebe, Giffen, Paul, Goncalves, Andrea, Churcher, Ian, Scott-Stevens, Paul, Harling, John D
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase
Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics
Mahajan, Mukesh K., Rivera, Elizabeth J., Sun, Helen H., Nagilla, Rakesh, DeMartino, Michael P., Haile, Pamela A., Casillas, Linda N., Marquis, Robert W., Votta, Bartholomew J., Bertin, John, Reilly, Michael A.
Published in Journal of pharmaceutical sciences (01.10.2020)
Published in Journal of pharmaceutical sciences (01.10.2020)
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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
Haffner, Curt D, Charnley, Adam K, Aquino, Christopher J, Casillas, Linda, Convery, Máire A, Cox, Julie A, Elban, Mark A, Goodwin, Nicole C, Gough, Peter J, Haile, Pamela A, Hughes, Terry V, Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S, Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F, Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J, Zhou, Huiqiang, Bertin, John, Marquis, Robert W
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Total Synthesis of Brevetoxin A
Crimmins, Michael T, Zuccarello, J. Lucas, Ellis, J. Michael, McDougall, Patrick J, Haile, Pamela A, Parrish, Jonathan D, Emmitte, Kyle A
Published in Organic letters (15.01.2009)
Published in Organic letters (15.01.2009)
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Silylene-Mediated Ring Contraction of Homoallylic Ethers To Form Allylic Silanes
Bourque, Laura E, Haile, Pamela A, Woerpel, K. A
Published in Journal of organic chemistry (18.09.2009)
Published in Journal of organic chemistry (18.09.2009)
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Silylene oxonium ylides: di- tert-butylsilylene insertion into C–O bonds
Bourque, Laura E., Haile, Pamela A., Loy, Janice M.N., Woerpel, K.A.
Published in Tetrahedron (11.07.2009)
Published in Tetrahedron (11.07.2009)
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CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood
Wang, Gren Z., Haile, Pamela A., Daniel, Tom, Belot, Benjamin, Viet, Andrew Q., Goodman, Krista B., Sha, Deyou, Dowdell, Sarah E., Varga, Norbert, Hong, Xuan, Chakravorty, Subhas, Webb, Christine, Cornejo, Carla, Olzinski, Alan, Bernard, Roberta, Evans, Christopher, Emmons, Amanda, Briand, Jacques, Chung, Chun-Wa, Quek, Ruben, Lee, Dennis, Gough, Peter J., Sehon, Clark A.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Ion−Molecule Chemistry within Boron Tribromide Clusters: Experiment and Theory
Hales, David A, Kautzman, Kathryn E, Williams, Nathan G, Haile, Pamela A, Barker, Michael P
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (29.03.2007)
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (29.03.2007)
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RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.
Published in Molecular cell (20.11.2014)
Published in Molecular cell (20.11.2014)
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QUINAZOLINES AS KINASE INHIBITORS
CASILLAS LINDA N, DONG XIAOYANG, CHARNLEY ADAM KENNETH, MEHLMANN JOHN F, DEMARTINO MICHAEL P, HAILE PAMELA A
Year of Publication 21.10.2015
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Year of Publication 21.10.2015
Patent
AMINO-QUINOLINES AS KINASE INHIBITORS
CASILLAS LINDA N, RAMANJULU JOSHI M, MEHLMANN JOHN F, DEMARTINO MICHAEL P, SINGHAUS ROBERT JR, HAILE PAMELA A
Year of Publication 19.05.2015
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Year of Publication 19.05.2015
Patent
AMINO-QUINOLINES AS KINASE INHIBITORS
CASILLAS LINDA N, MARQUIS ROBERT W. JR, CHARNLEY ADAM KENNETH, MEHLMANN JOHN F, SINGHAUS ROBERT R, BURY MICHAEL JONATHAN, HAILE PAMELA A, ROMANO JOSEPH J, WANG GREN Z
Year of Publication 24.01.2014
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Year of Publication 24.01.2014
Patent
AMINO QUINAZOLINES AS KINASE INHIBITORS
RAMANJULU JOSHI M, CHARNLEY ADAM KENNETH, DEMARTINO MICHAEL P, BURY MICHAEL JONATHAN, HAILE PAMELA A, CASILLAS LINDA N, EIDAM PATRICK M, MARQUIS ROBERT W. JR, DONG XIAOYANG, SHAH AMI LAKDAWALA, WANG GREN, SINGHAUS ROBERT R. JR, ROMANO JOSEPH J
Year of Publication 08.05.2014
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Year of Publication 08.05.2014
Patent
Silyiene-Mediated Ring Contraction of Homoallylic Ethers To Form Allylic Silanes
Bourque, Laura E., Haile, Pamela A., Woerpel, K. A.
Published in Journal of organic chemistry (18.09.2009)
Published in Journal of organic chemistry (18.09.2009)
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