Nonpeptide Urotensin-II Receptor Antagonists: A New Ligand Class Based on Piperazino-Phthalimide and Piperazino-Isoindolinone Subunits
Lawson, Edward C, Luci, Diane K, Ghosh, Shyamali, Kinney, William A, Reynolds, Charles H, Qi, Jenson, Smith, Charles E, Wang, Yuanping, Minor, Lisa K, Haertlein, Barbara J, Parry, Tom J, Damiano, Bruce P, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
Get full text
Journal Article
Dual Inhibition of Cathepsin G and Chymase Is Effective in Animal Models of Pulmonary Inflammation
Maryanoff, Bruce E, de Garavilla, Lawrence, Greco, Michael N, Haertlein, Barbara J, Wells, Grace I, Andrade-Gordon, Patricia, Abraham, William M
Published in American journal of respiratory and critical care medicine (01.02.2010)
Published in American journal of respiratory and critical care medicine (01.02.2010)
Get full text
Journal Article
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo
de Garavilla, Lawrence, Greco, Michael N, Sukumar, Narayanasami, Chen, Zhi-Wei, Pineda, Agustin O, Mathews, F Scott, Di Cera, Enrico, Giardino, Edward C, Wells, Grace I, Haertlein, Barbara J, Kauffman, Jack A, Corcoran, Thomas W, Derian, Claudia K, Eckardt, Annette J, Damiano, Bruce P, Andrade-Gordon, Patricia, Maryanoff, Bruce E
Published in The Journal of biological chemistry (06.05.2005)
Published in The Journal of biological chemistry (06.05.2005)
Get full text
Journal Article
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design
Costanzo, Michael J, Almond, Harold R, Hecker, Leonard R, Schott, Mary R, Yabut, Stephen C, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W, Giardino, Edward C, Kauffman, Jack A, Lewis, Joan M, de Garavilla, Lawrence, Haertlein, Barbara J, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
Get full text
Journal Article
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif
Kreutter, Kevin D., Lu, Tianbao, Lee, Lily, Giardino, Edward C., Patel, Sharmila, Huang, Hui, Xu, Guozhang, Fitzgerald, Mark, Haertlein, Barbara J., Mohan, Venkatraman, Crysler, Carl, Eisennagel, Stephen, Dasgupta, Malini, McMillan, Martin, Spurlino, John C., Huebert, Norman D., Maryanoff, Bruce E., Tomczuk, Bruce E., Damiano, Bruce P., Player, Mark R.
Published in Bioorganic & medicinal chemistry (01.05.2008)
Published in Bioorganic & medicinal chemistry (01.05.2008)
Get full text
Journal Article
Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa
Giardino, Edward C, Haertlein, Barbara J, de Garavilla, Lawrence, Costanzo, Michael J, Damiano, Bruce P, Andrade-Gordon, Patricia, Maryanoff, Bruce E
Published in Blood coagulation & fibrinolysis (01.03.2010)
Published in Blood coagulation & fibrinolysis (01.03.2010)
Get more information
Journal Article
Administration of a Potent Antagonist of Protease-Activated Receptor-1 (PAR-1) Attenuates Vascular Restenosis Following Balloon Angioplasty in Rats
Andrade-Gordon, P, Derian, C K, Maryanoff, B E, Zhang, H C, Addo, M F, Cheung Wm, Damiano, B P, D'Andrea, M R, Darrow, A L, de Garavilla, L, Eckardt, A J, Giardino, E C, Haertlein, B J, McComsey, D F
Published in The Journal of pharmacology and experimental therapeutics (01.07.2001)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.07.2001)
Journal Article
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design
Costanzo, Michael J, Almond, Harold R, Hecker, Leonard R, Schott, Mary R, Yabut, Stephen C, Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W, Giardino, Edward C, Kauffman, Jack A, Lewis, Joan M, de Garavilla, Lawrence, Haertlein, Barbara J, Maryanoff, Bruce E
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
Get full text
Journal Article
A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase
de Garavilla, Lawrence, Greco, Michael N., Sukumar, Narayanasami, Chen, Zhi-Wei, Pineda, Agustin O., Mathews, F. Scott, Di Cera, Enrico, Giardino, Edward C., Wells, Grace I., Haertlein, Barbara J., Kauffman, Jack A., Corcoran, Thomas W., Derian, Claudia K., Eckardt, Annette J., Damiano, Bruce P., Andrade-Gordon, Patricia, Maryanoff, Bruce E.
Published in The Journal of biological chemistry (06.05.2005)
Published in The Journal of biological chemistry (06.05.2005)
Get full text
Journal Article
Antiplatelet and Antithrombotic Activity of RWJ-53308, A Novel Orally Active Glycoprotein IIb/IIIa Antagonist
Damiano, Bruce P, Mitchell, John A, Giardino, Edward, Corcoran, Thomas, Haertlein, Barbara J, de Garavilla, Lawrence, Kauffman, Jack A, Hoekstra, William J, Maryanoff, Bruce E, Andrade-Gordon, Patricia
Published in Thrombosis research (15.10.2001)
Published in Thrombosis research (15.10.2001)
Get full text
Journal Article
Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation, and regulation by protein kinases
Derian, Claudia K., Santulli, Rosemary J., Tomko, Karen A., Haertlein, Barbara J., Andrade-Gordon, Patricia
Published in Thrombosis research (15.06.1995)
Published in Thrombosis research (15.06.1995)
Get full text
Journal Article
In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S-1 ' subsite and its implications to structure-based drug design
Costanzo, MJ, Almond, HR, Hecker, LR, Schott, MR, Yabut, SC, Zhang, HC, Andrade-Gordon, P, Corcoran, TW, Giardino, EC, Kauffman, JA, Lewis, JM, de Garavilla, L, Haertlein, BJ, Maryanoff, BE
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
Get full text
Journal Article
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S 1 ‘ Subsite and Its Implications to Structure-Based Drug Design
Costanzo, Michael J., Almond, Harold R., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W., Giardino, Edward C., Kauffman, Jack A., Lewis, Joan M., de Garavilla, Lawrence, Haertlein, Barbara J., Maryanoff, Bruce E.
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
Get full text
Journal Article
Potent, Orally Active GPIIb/IIIa Antagonists Containing a Nipecotic Acid Subunit. Structure−Activity Studies Leading to the Discovery of RWJ-53308
Hoekstra, William J, Maryanoff, Bruce E, Damiano, Bruce P, Andrade-Gordon, Patricia, Cohen, Judith H, Costanzo, Michael J, Haertlein, Barbara J, Hecker, Leonard R, Hulshizer, Becky L, Kauffman, Jack A, Keane, Patricia, McComsey, David F, Mitchell, John A, Scott, Lorraine, Shah, Rekha D, Yabut, Stephen C
Published in Journal of medicinal chemistry (16.12.1999)
Published in Journal of medicinal chemistry (16.12.1999)
Get full text
Journal Article
In-depth study of tripeptide-based α-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug designs
COSTANZO, Michael J, ALMOND, Harold R, LEWIS, Joan M, DE GARAVILLA, Lawrence, HAERTLEIN, Barbara J, MARYANOFF, Bruce E, HECKER, Leonard R, SCHOTT, Mary R, YABUT, Stephen C, ZHANG, Han-Cheng, ANDRADE-GORDON, Patricia, CORCORAN, Thomas W, GIARDINO, Edward C, KAUFFMAN, Jack A
Published in Journal of medicinal chemistry (2005)
Get full text
Published in Journal of medicinal chemistry (2005)
Journal Article
Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042
Hoekstra, William J., Maryanoff, Bruce E., Andrade-Gordon, Patricia, Cohen, Judith H., Costanzo, Michael J., Damiano, Bruce P., Haertlein, Barbara J., Harris, Bruce D., Kauffman, Jack A., Keane, Patricia M., McComsey, David F., Villani, Frank J., Yabut, Stephen C.
Published in Bioorganic & medicinal chemistry letters (22.10.1996)
Published in Bioorganic & medicinal chemistry letters (22.10.1996)
Get full text
Journal Article
Novel thieno[2,3- b]- and [3,4- b]pyrans as potassium channel openers. Thiophene systems—XVII
Press, Jeffery B., McNally, James J., Sanfilippo, Pauline J., Addo, Michael F., Loughney, Deborah, Giardino, Edward, Katz, Laurence B., Falotico, Robert, Haertlein, Barbara J.
Published in Bioorganic & medicinal chemistry (01.12.1993)
Published in Bioorganic & medicinal chemistry (01.12.1993)
Get full text
Journal Article