Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics
Haeggström, Jesper Z, Newcomer, Marcia E
Published in Annual review of pharmacology and toxicology (20.01.2023)
Published in Annual review of pharmacology and toxicology (20.01.2023)
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Investigation of Clozapine and Olanzapine Reactive Metabolite Formation and Protein Binding by Liquid Chromatography-Tandem Mass Spectrometry
Geib, Timon, Thulasingam, Madhuranayaki, Haeggström, Jesper Z, Sleno, Lekha
Published in Chemical research in toxicology (21.09.2020)
Published in Chemical research in toxicology (21.09.2020)
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The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes
Tang, Xiao, Teder, Tarvi, Samuelsson, Bengt, Haeggström, Jesper Z
Published in Frontiers in pharmacology (22.03.2022)
Published in Frontiers in pharmacology (22.03.2022)
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Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction
Tang, Xiao, Rönnberg, Elin, Säfholm, Jesper, Thulasingam, Madhuranayaki, Trauelsen, Mette, Schwartz, Thue W., Wheelock, Craig E., Dahlén, Sven‐Erik, Nilsson, Gunnar, Haeggström, Jesper Z.
Published in Allergy (Copenhagen) (01.09.2022)
Published in Allergy (Copenhagen) (01.09.2022)
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A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression
Zhang, Jie, Ye, Zhi-wei, Bräutigam, Lars, Chakraborty, Paramita, Luo, Zhenwu, Culpepper, John, Aslam, Muhammad, Zhang, Leilei, Johansson, Katarina, Haeggström, Jesper Z., Xu, Jianqiang, Olsson, Magnus, Townsend, Danyelle M., Mehrotra, Shikhar, Morgenstern, Ralf, Tew, Kenneth D.
Published in The Journal of biological chemistry (01.08.2023)
Published in The Journal of biological chemistry (01.08.2023)
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Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
Stsiapanava, Alena, Olsson, Ulrika, Wan, Min, Kleinschmidt, Thea, Rutishauser, Dorothea, Zubarev, Roman A., Samuelsson, Bengt, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.2014)
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Cathelicidin LL-37 Induces Angiogenesis via PGE2–EP3 Signaling in Endothelial Cells, In Vivo Inhibition by Aspirin
Salvado, M Dolores, Di Gennaro, Antonio, Lindbom, Lennart, Agerberth, Birgitta, Haeggström, Jesper Z
Published in Arteriosclerosis, thrombosis, and vascular biology (01.08.2013)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.08.2013)
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Journal Article
Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A4 Hydrolase
Teder, Tarvi, König, Stefanie, Singh, Rajkumar, Samuelsson, Bengt, Werz, Oliver, Garscha, Ulrike, Haeggström, Jesper Z.
Published in International journal of molecular sciences (19.04.2023)
Published in International journal of molecular sciences (19.04.2023)
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Journal Article
Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm
Di Gennaro, Antonio, Araújo, Ana Carolina, Busch, Albert, Jin, Hong, Wågsäter, Dick, Vorkapic, Emina, Caidahl, Kenneth, Eriksson, Per, Samuelsson, Bengt, Maegdefessel, Lars, Haeggström, Jesper Z.
Published in Proceedings of the National Academy of Sciences - PNAS (20.02.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (20.02.2018)
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Journal Article
Catalytic Characterization of Human Microsomal Glutathione S‑Transferase 2: Identification of Rate-Limiting Steps
Ahmad, Shabbir, Niegowski, Damian, Wetterholm, Anders, Haeggström, Jesper Z, Morgenstern, Ralf, Rinaldo-Matthis, Agnes
Published in Biochemistry (Easton) (12.03.2013)
Published in Biochemistry (Easton) (12.03.2013)
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A dynamic Asp–Arg interaction is essential for catalysis in microsomal prostaglandin E₂ synthase
Brock, Joseph S., Hamberg, Mats, Balagunaseelan, Navisraj, Goodman, Michael, Morgenstern, Ralf, Strandback, Emilia, Samuelsson, Bengt, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2016)
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Leukotriene B₄-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin)
Di Gennaro, Antonio, Kenne, Ellinor, Wan, Min, Soehnlein, Oliver, Lindbom, Lennart, Haeggström, Jesper Z
Published in The FASEB journal (01.06.2009)
Published in The FASEB journal (01.06.2009)
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Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase
MARTINEZ MOLINA, Daniel, WETTERHOLM, Anders, KOHL, Andreas, MCCARTHY, Andrew A, NIEGOWSKI, Damian, OHLSON, Eva, HAMMARBERG, Tove, ESHAGHI, Said, HAEGGSTRÖM, Jesper Z, NORDLUND, Pär
Published in Nature (London) (02.08.2007)
Published in Nature (London) (02.08.2007)
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Journal Article
Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations[S]
Lundström, Susanna L., Saluja, Rohit, Adner, Mikael, Haeggström, Jesper Z., Nilsson, Gunnar, Wheelock, Craig E.
Published in Journal of lipid research (01.01.2013)
Published in Journal of lipid research (01.01.2013)
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Journal Article
Structure and inhibition of mouse leukotriene C4 synthase
Niegowski, Damian, Kleinschmidt, Thea, Ahmad, Shabbir, Qureshi, Abdul Aziz, Mårback, Michaela, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z
Published in PloS one (08.05.2014)
Published in PloS one (08.05.2014)
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Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids
Lundström, Susanna L., Yang, Jun, Brannan, John D., Haeggström, Jesper Z., Hammock, Bruce D., Nair, Parameswaran, O'Byrne, Paul, Dahlén, Sven-Erik, Wheelock, Craig E.
Published in Molecular nutrition & food research (01.08.2013)
Published in Molecular nutrition & food research (01.08.2013)
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Expression of 5-Lipoxygenase and Leukotriene A₄ Hydrolase in Human Atherosclerotic Lesions Correlates with Symptoms of Plaque Instability
Qiu, Hong, Gabrielsen, Anders, Agardh, Hanna E., Wan, Min, Wetterholm, Anders, Wong, Chi-Huey, Hedin, Ulf, Swedenborg, Jesper, Hansson, Göran K., Samuelsson, Bengt, Paulsson-Berne, Gabrielle, Haeggström, Jesper Z.
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2006)
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