Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model
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Published in Nature communications (21.08.2019)
Published in Nature communications (21.08.2019)
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Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor
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Published in The New England journal of medicine (30.07.2015)
Published in The New England journal of medicine (30.07.2015)
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RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
Su, Fei, Viros, Amaya, Milagre, Carla, Trunzer, Kerstin, Bollag, Gideon, Spleiss, Olivia, Reis-Filho, Jorge S, Kong, Xiangju, Koya, Richard C, Flaherty, Keith T, Chapman, Paul B, Kim, Min Jung, Hayward, Robert, Martin, Matthew, Yang, Hong, Wang, Qiongqing, Hilton, Holly, Hang, Julie S, Noe, Johannes, Lambros, Maryou, Geyer, Felipe, Dhomen, Nathalie, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Zambon, Alfonso, Preece, Natasha, Robert, Lídia, Otte, Nicholas J, Mok, Stephen, Kee, Damien, Ma, Yan, Zhang, Chao, Habets, Gaston, Burton, Elizabeth A, Wong, Bernice, Nguyen, Hoa, Kockx, Mark, Andries, Luc, Lestini, Brian, Nolop, Keith B, Lee, Richard J, Joe, Andrew K, Troy, James L, Gonzalez, Rene, Hutson, Thomas E, Puzanov, Igor, Chmielowski, Bartosz, Springer, Caroline J, McArthur, Grant A, Sosman, Jeffrey A, Lo, Roger S, Ribas, Antoni, Marais, Richard
Published in The New England journal of medicine (19.01.2012)
Published in The New England journal of medicine (19.01.2012)
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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF -mutant melanoma
Marimuthu, Adhirai, D'Andrea, Kurt, Lin, Paul S, Puzanov, Igor, Chapman, Paul B, Zhang, Jiazhong, Tsai, James, Ibrahim, Prabha N, Cho, Hanna, West, Brian L, Nathanson, Katherine L, Zhang, Kam Y. J, Zhang, Ying, Nolop, Keith, Schlessinger, Joseph, Grippo, Joseph, Shellooe, Rafe, Zhang, Chao, Flaherty, Keith T, Tsang, Garson, Powell, Ben, Kim, Kevin B, Wong, Bernice, Stumm, Michael, Ribas, Antoni, Spevak, Wayne, Higgins, Brian, Sosman, Jeffrey A, Artis, Dean R, Habets, Gaston, Hirth, Peter, Burton, Elizabeth A, Iyer, Raman, Su, Fei, Koehler, Astrid, Lee, Richard J, Bollag, Gideon, Nguyen, Hoa, McArthur, Grant A, Xu, Xiaowei
Published in Nature (London) (30.09.2010)
Published in Nature (London) (30.09.2010)
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Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor
Zhang, Chao, Ibrahim, Prabha N., Zhang, Jiazhong, Burton, Elizabeth A., Habets, Gaston, Zhang, Ying, Powell, Ben, West, Brian L., Matusow, Bernice, Tsang, Garson, Shellooe, Rafe, Carias, Heidi, Nguyen, Hoa, Marimuthu, Adhirai, Zhang, Kam Y. J., Oh, Angela, Bremer, Ryan, Hurt, Clarence R., Artis, Dean R., Wu, Guoxian, Nespi, Marika, Spevak, Wayne, Lin, Paul, Nolop, Keith, Hirth, Peter, Tesch, Greg H., Bollag, Gideon
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
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Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
O'Shea, Clodagh C., Johnson, Leisa, Bagus, Bridget, Choi, Serah, Nicholas, Cory, Shen, Annie, Boyle, Larry, Pandey, Kusum, Soria, Conrado, Kunich, John, Shen, Yuqiao, Habets, Gaston, Ginzinger, Dave, McCormick, Frank
Published in Cancer cell (01.12.2004)
Published in Cancer cell (01.12.2004)
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Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer
Thompson, Michelle L, Jimenez-Andrade, Juan M, Chartier, Stephane, Tsai, James, Burton, Elizabeth A, Habets, Gaston, Lin, Paul S, West, Brian L, Mantyh, Patrick W
Published in Pain (Amsterdam) (01.09.2015)
Published in Pain (Amsterdam) (01.09.2015)
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A role for Rac in Tiaml-induced membrane ruffling and invasion
Michiels, Frits, Habets, Gaston G. M, Stam, Jord C, van der Kammen, Rob A, Collard, John G
Published in Nature (London) (25.05.1995)
Published in Nature (London) (25.05.1995)
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RAF inhibitors that evade paradoxical MAPK pathway activation
Zhang, Chao, Spevak, Wayne, Zhang, Ying, Burton, Elizabeth A, Ma, Yan, Habets, Gaston, Zhang, Jiazhong, Lin, Jack, Ewing, Todd, Matusow, Bernice, Tsang, Garson, Marimuthu, Adhirai, Cho, Hanna, Wu, Guoxian, Wang, Weiru, Fong, Daniel, Nguyen, Hoa, Shi, Songyuan, Womack, Patrick, Nespi, Marika, Shellooe, Rafe, Carias, Heidi, Powell, Ben, Light, Emily, Sanftner, Laura, Walters, Jason, Tsai, James, West, Brian L, Visor, Gary, Rezaei, Hamid, Lin, Paul S, Nolop, Keith, Ibrahim, Prabha N, Hirth, Peter, Bollag, Gideon
Published in Nature (London) (22.10.2015)
Published in Nature (London) (22.10.2015)
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Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397
Smith, Catherine C, Zhang, Chao, Lin, Kimberly C, Lasater, Elisabeth A, Zhang, Ying, Massi, Evan, Damon, Lauren E, Pendleton, Matthew, Bashir, Ali, Sebra, Robert, Perl, Alexander, Kasarskis, Andrew, Shellooe, Rafe, Tsang, Garson, Carias, Heidi, Powell, Ben, Burton, Elizabeth A, Matusow, Bernice, Zhang, Jiazhong, Spevak, Wayne, Ibrahim, Prabha N, Le, Mai H, Hsu, Henry H, Habets, Gaston, West, Brian L, Bollag, Gideon, Shah, Neil P
Published in Cancer discovery (01.06.2015)
Published in Cancer discovery (01.06.2015)
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BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor
Ozer, Hatice Gulcin, El-Gamal, Dalia, Powell, Ben, Hing, Zachary A, Blachly, James S, Harrington, Bonnie, Mitchell, Shaneice, Grieselhuber, Nicole R, Williams, Katie, Lai, Tzung-Huei, Alinari, Lapo, Baiocchi, Robert A, Brinton, Lindsey, Baskin, Elizabeth, Cannon, Matthew, Beaver, Larry, Goettl, Virginia M, Lucas, David M, Woyach, Jennifer A, Sampath, Deepa, Lehman, Amy M, Yu, Lianbo, Zhang, Jiazhong, Ma, Yan, Zhang, Ying, Spevak, Wayne, Shi, Songyuan, Severson, Paul, Shellooe, Rafe, Carias, Heidi, Tsang, Garson, Dong, Ken, Ewing, Todd, Marimuthu, Adhirai, Tantoy, Christina, Walters, Jason, Sanftner, Laura, Rezaei, Hamid, Nespi, Marika, Matusow, Bernice, Habets, Gaston, Ibrahim, Prabha, Zhang, Chao, Mathé, Ewy A, Bollag, Gideon, Byrd, John C, Lapalombella, Rosa
Published in Cancer discovery (01.04.2018)
Published in Cancer discovery (01.04.2018)
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Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity
Tsai, James, Lee, John T., Wang, Weiru, Zhang, Jiazhong, Cho, Hanna, Mamo, Shumeye, Bremer, Ryan, Gillette, Sam, Kong, Jun, Haass, Nikolas K., Sproesser, Katrin, Li, Ling, Smalley, Keiran S. M., Fong, Daniel, Zhu, Yong-Liang, Marimuthu, Adhirai, Nguyen, Hoa, Lam, Billy, Liu, Jennifer, Cheung, Ivana, Rice, Julie, Suzuki, Yoshihisa, Luu, Catherine, Settachatgul, Calvin, Shellooe, Rafe, Cantwell, John, Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y. J., West, Brian L., Powell, Ben, Habets, Gaston, Zhang, Chao, Ibrahim, Prabha N., Hirth, Peter, Artis, Dean R., Herlyn, Meenhard, Bollag, Gideon
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2008)
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Abstract 7264: OPN-9840, a non-covalent potent pan-TEAD inhibitor, exhibits single agent efficacy in preclinical malignant mesothelioma models
Chen, Pan-Yu, Matusow, Bernice, Tsai, James, Li, Peipei, Nguyen, Hoa, Habets, Gaston, Bollag, Gideon, Chowdhury, Somenath
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 660: OPN-6602, a potent dual EP300/CBP bromodomain inhibitor, targets multiple myeloma through concomitant suppression of IRF4 and c-MYC
Matusow, Bernice, Spevak, Wayne, Zhang, Chao, Ma, Yan, Shellooe, Rafe, Tsai, James, Li, Pei Pei, Yu Chen, Pan, Habets, Gaston, Nichols, Christine, Singh, Parmveer, Inokuchi, Kerry, Walling, Jackie, Halladay, Jason, Bollag, Gideon
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors: A Phase 1b/2a Nonrandomized Clinical Trial
Wagner, Andrew J, Severson, Paul L, Shields, Anthony F, Patnaik, Amita, Chugh, Rashmi, Tinoco, Gabriel, Wu, Guoxian, Nespi, Marika, Lin, Jack, Zhang, Ying, Ewing, Todd, Habets, Gaston, Burton, Elizabeth A, Matusow, Bernice, Tsai, James, Tsang, Garson, Shellooe, Rafe, Carias, Heidi, Chan, Katrina, Rezaei, Hamid, Sanftner, Laura, Marimuthu, Adhirai, Spevak, Wayne, Ibrahim, Prabha N, Inokuchi, Kerry, Alcantar, Oscar, Michelson, Glenn, Tsiatis, Athanasios C, Zhang, Chao, Bollag, Gideon, Trent, Jonathan C, Tap, William D
Published in JAMA oncology (01.09.2021)
Published in JAMA oncology (01.09.2021)
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Abstract C085: OPN-6602, a dual EP300/CBP bromodomain inhibitor modulates androgen-driven transcription, including MYC, in mCRPC
Matusow, Bernice, Spevak, Wayne, Zhang, Chao, Ma, Yan, Shellooe, Rafe, Li, Peipei, Tsai, James, Yu Chen, Pan, Singh, Parmveer, Walling, Jackie, Nichols, Christine, Halladay, Jason, Inokuchi, Kerry, Habets, Gaston, Bollag, Gideon
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Abstract 4711: Broad anti-tumor activity of a novel BET bromodomain inhibitor
Ma, Yan, Powell, Ben, Zhang, Jiazhong, Zhang, Ying, Carias, Heidi, Schwertschlag, Ullrich, Habets, Gaston, Ibrahim, Prabha, Spevak, Wayne, Zhang, Chao, Bollag, Gideon
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors
Gebreyohannes, Yemarshet K., Burton, Elizabeth A., Wozniak, Agnieszka, Matusow, Bernice, Habets, Gaston, Wellens, Jasmien, Cornillie, Jasmien, Lin, Jack, Nespi, Marika, Wu, Guoxian, Zhang, Chao, Bollag, Gideon, Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick
Published in Clinical and experimental medicine (01.05.2019)
Published in Clinical and experimental medicine (01.05.2019)
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