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Published in Nature (London) (01.08.2018)
Published in Nature (London) (01.08.2018)
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A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, Kp,uu
Lawrenz, Morgan, Svensson, Mats, Kato, Mitsunori, Dingley, Karen H., Chief Elk, Jackson, Nie, Zhe, Zou, Yefen, Kaplan, Zachary, Lagiakos, H. Rachel, Igawa, Hideyuki, Therrien, Eric
Published in Journal of chemical information and modeling (26.06.2023)
Published in Journal of chemical information and modeling (26.06.2023)
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Journal Article
A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, K p,uu
Lawrenz, Morgan, Svensson, Mats, Kato, Mitsunori, Dingley, Karen H, Chief Elk, Jackson, Nie, Zhe, Zou, Yefen, Kaplan, Zachary, Lagiakos, H Rachel, Igawa, Hideyuki, Therrien, Eric
Published in Journal of chemical information and modeling (26.06.2023)
Published in Journal of chemical information and modeling (26.06.2023)
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In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas
Ottavi, Samantha, Scarry, Sarah M, Mosior, John, Ling, Yan, Roberts, Julia, Singh, Amrita, Zhang, David, Goullieux, Laurent, Roubert, Christine, Bacqué, Eric, Lagiakos, H. Rachel, Vendome, Jeremie, Moraca, Francesca, Li, Kelin, Perkowski, Andrew J, Ramesh, Remya, Bowler, Matthew M, Tracy, William, Feher, Victoria A, Sacchettini, James C, Gold, Ben S, Nathan, Carl F, Aubé, Jeffrey
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Published in Journal of medicinal chemistry (10.02.2022)
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Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
Sharma, Shikhar, Chung, Chi-Yeh, Uryu, Sean, Petrovic, Jelena, Cao, Joan, Rickard, Amanda, Nady, Nataliya, Greasley, Samantha, Johnson, Eric, Brodsky, Oleg, Khan, Showkhin, Wang, Hui, Wang, Zhenxiong, Zhang, Yong, Tsaparikos, Konstantinos, Chen, Lei, Mazurek, Anthony, Lapek, John, Kung, Pei-Pei, Sutton, Scott, Richardson, Paul F., Greenwald, Eric C., Yamazaki, Shinji, Jones, Rhys, Maegley, Karen A., Bingham, Patrick, Lam, Hieu, Stupple, Alexandra E., Kamal, Aileen, Chueh, Anderly, Cuzzupe, Anthony, Morrow, Benjamin J., Ren, Bin, Carrasco-Pozo, Catalina, Tan, Chin Wee, Bhuva, Dharmesh D., Allan, Elizabeth, Surgenor, Elliot, Vaillant, François, Pehlivanoglu, Havva, Falk, Hendrik, Whittle, James R., Newman, Janet, Cursons, Joseph, Doherty, Judy P., White, Karen L., MacPherson, Laura, Devlin, Mark, Dennis, Matthew L., Hattarki, Meghan K., De Silva, Melanie, Camerino, Michelle A., Butler, Miriam S., Dolezal, Olan, Pilling, Patricia, Foitzik, Richard, Stupple, Paul A., Lagiakos, H. Rachel, Walker, Scott R., Hediyeh-Zadeh, Soroor, Nuttall, Stewart, Spall, Sukhdeep K., Charman, Susan A., Connor, Theresa, Peat, Thomas S., Avery, Vicky M., Bozikis, Ylva E., Yang, Yuqing, Zhang, Ming, Monahan, Brendon J., Voss, Anne K., Thomas, Tim, Street, Ian P., Dawson, Sarah-Jane, Dawson, Mark A., Lindeman, Geoffrey J., Davis, Melissa J., Visvader, Jane E., Paul, Thomas A.
Published in Cell chemical biology (19.10.2023)
Published in Cell chemical biology (19.10.2023)
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Empowering Voices: Inspiring Women in Medicinal Chemistry
Blanco, Maria-Jesus, Bronson, Joanne J., DiMauro, Erin F., Dzierba, Carolyn, Eggen, MariJean, Garner, Amanda L., Georg, Gunda, Giarolla, Jeanine, Goodwin, Nicole C., Grenier-Davies, Melissa C., Haskell-Luevano, Carrie, Holzgrabe, Ulrike, Huang, Rong, Lagiakos, H. Rachel, Leftheris, Katerina, Martin, Yvonne, Matos, Maria João, May-Dracka, Tricia L., Müller, Christa E., Newman, Amy H., Parmee, Emma, Petter, Jennifer C., Tamayo, Nuria A., Wexler, Ruth R., Bolognesi, Maria Laura, Ripka, Amy, Young, Wendy
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A
Leaver, David J, Cleary, Benjamin, Nguyen, Nghi, Priebbenow, Daniel L, Lagiakos, H. Rachel, Sanchez, Julie, Xue, Lian, Huang, Fei, Sun, Yuxin, Mujumdar, Prashant, Mudududdla, Ramesh, Varghese, Swapna, Teguh, Silvia, Charman, Susan A, White, Karen L, Katneni, Kasiram, Cuellar, Matthew, Strasser, Jessica M, Dahlin, Jayme L, Walters, Michael A, Street, Ian P, Monahan, Brendon J, Jarman, Kate E, Sabroux, Helene Jousset, Falk, Hendrik, Chung, Matthew C, Hermans, Stefan J, Parker, Michael W, Thomas, Tim, Baell, Jonathan B
Published in Journal of medicinal chemistry (08.08.2019)
Published in Journal of medicinal chemistry (08.08.2019)
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Journal Article
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents
Priebbenow, Daniel L, Leaver, David J, Nguyen, Nghi, Cleary, Benjamin, Lagiakos, H. Rachel, Sanchez, Julie, Xue, Lian, Huang, Fei, Sun, Yuxin, Mujumdar, Prashant, Mudududdla, Ramesh, Varghese, Swapna, Teguh, Silvia, Charman, Susan A, White, Karen L, Shackleford, David M, Katneni, Kasiram, Cuellar, Matthew, Strasser, Jessica M, Dahlin, Jayme L, Walters, Michael A, Street, Ian P, Monahan, Brendon J, Jarman, Kate E, Jousset Sabroux, Helene, Falk, Hendrik, Chung, Matthew C, Hermans, Stefan J, Downer, Natalie L, Parker, Michael W, Voss, Anne K, Thomas, Tim, Baell, Jonathan B
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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Published in ACS medicinal chemistry letters (11.04.2024)
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