Search Results - "Hüttelmaier, Stefan"

Mass Spectrometric Identification of SARS-CoV‑2 Proteins from Gargle Solution Samples of COVID-19 Patients by Ihling, Christian, Tänzler, Dirk, Hagemann, Sven, Kehlen, Astrid, Hüttelmaier, Stefan, Arlt, Christian, Sinz, Andrea

“…Mass spectrometry (MS) can deliver valuable diagnostic data that complement genomic information and allow us to increase our current knowledge of the COVID-19…”

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The Critical Role of RNA m6A Methylation in Cancer by Lan, Qing, Liu, Pei Y., Haase, Jacob, Bell, Jessica L., Hüttelmaier, Stefan, Liu, Tao

“…Since the identification of the first RNA demethylase and the establishment of methylated RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA…”

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The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer by Lederer, Marcell, Bley, Nadine, Schleifer, Christian, Hüttelmaier, Stefan

“…The post-transcriptional control of gene expression mediated by RNA-binding proteins (RBPs), long non-coding RNAs (lncRNAs) as well as miRNAs is essential to…”

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Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs by Schöller, Eva, Marks, James, Marchand, Virginie, Bruckmann, Astrid, Powell, Christopher A., Reichold, Markus, Mutti, Christian Daniel, Dettmer, Katja, Feederle, Regina, Hüttelmaier, Stefan, Helm, Mark, Oefner, Peter, Minczuk, Michal, Motorin, Yuri, Hafner, Markus, Meister, Gunter

“…Mitochondria contain a specific translation machinery for the synthesis of mitochondria-encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs)…”

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The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer by Müller, Simon, Bley, Nadine, Busch, Bianca, Glaß, Markus, Lederer, Marcell, Misiak, Claudia, Fuchs, Tommy, Wedler, Alice, Haase, Jacob, Bertoldo, Jean Borges, Michl, Patrick, Hüttelmaier, Stefan

“…Abstract The IGF2 mRNA-binding protein 1 (IGF2BP1) is a non-catalytic post-transcriptional enhancer of tumor growth upregulated and associated with adverse…”

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The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription by Wong, Matthew, Tee, Andrew E.L., Milazzo, Giorgio, Bell, Jessica L., Poulos, Rebecca C., Atmadibrata, Bernard, Sun, Yuting, Jing, Duohui, Ho, Nicholas, Ling, Dora, Liu, Pei Yan, Zhang, Xu Dong, Hüttelmaier, Stefan, Wong, Jason W.H., Wang, Jenny, Polly, Patsie, Perini, Giovanni, Scarlett, Christopher J., Liu, Tao

“…Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of…”

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Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3 by Schneider, Tim, Hung, Lee-Hsueh, Aziz, Masood, Wilmen, Anna, Thaum, Stephanie, Wagner, Jacqueline, Janowski, Robert, Müller, Simon, Schreiner, Silke, Friedhoff, Peter, Hüttelmaier, Stefan, Niessing, Dierk, Sattler, Michael, Schlundt, Andreas, Bindereif, Albrecht

“…How multidomain RNA-binding proteins recognize their specific target sequences, based on a combinatorial code, represents a fundamental unsolved question and…”

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Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? by Bell, Jessica L, Wächter, Kristin, Mühleck, Britta, Pazaitis, Nikolaos, Köhn, Marcel, Lederer, Marcell, Hüttelmaier, Stefan

“…The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2, IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins…”

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Insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma by Gutschner, Tony, Hämmerle, Monika, Pazaitis, Nikolaos, Bley, Nadine, Fiskin, Evgenij, Uckelmann, Hannah, Heim, Andreas, Groβ, Matthias, Hofmann, Nina, Geffers, Robert, Skawran, Britta, Longerich, Thomas, Breuhahn, Kai, Schirmacher, Peter, Mühleck, Britta, Hüttelmaier, Stefan, Diederichs, Sven

“…Hepatocarcinogenesis is a stepwise process. It involves several genetic and epigenetic alterations, e.g., loss of tumor suppressor gene expression (TP53, PTEN,…”

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Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation by Weiße, Jonas, Rosemann, Julia, Müller, Lisa, Kappler, Matthias, Eckert, Alexander W., Glaß, Markus, Misiak, Danny, Hüttelmaier, Stefan, Ballhausen, Wolfgang G., Hatzfeld, Mechthild, Haemmerle, Monika, Gutschner, Tony

“…Cancer metastases are the main cause of lethality. The five-year survival rate for patients diagnosed with advanced stage oral cancer is 30%. Hence, the…”

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IGF2BP1—An Oncofetal RNA-Binding Protein Fuels Tumor Virus Propagation by Glaß, Markus, Hüttelmaier, Stefan

“…The oncofetal RNA-binding protein IGF2BP1 has been reported to be a driver of tumor progression in a multitude of cancer entities. Its main function is the…”

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Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways by Braun, Till, Glass, Markus, Wahnschaffe, Linus, Otte, Moritz, Mayer, Petra, Franitza, Marek, Altmüller, Janine, Hallek, Michael, Hüttelmaier, Stefan, Schrader, Alexandra, Herling, Marco

“…T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic mature T-cell malignancy. It typically presents with exponentially rising lymphocyte counts,…”

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HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins by Zinnall, Ulrike, Milek, Miha, Minia, Igor, Vieira-Vieira, Carlos H., Müller, Simon, Mastrobuoni, Guido, Hazapis, Orsalia-Georgia, Del Giudice, Simone, Schwefel, David, Bley, Nadine, Voigt, Franka, Chao, Jeffrey A., Kempa, Stefan, Hüttelmaier, Stefan, Selbach, Matthias, Landthaler, Markus

“…The biological role of RNA-binding proteins in the secretory pathway is not well established. Here, we describe that human HDLBP/Vigilin directly interacts…”

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UNR/CSDE1 Drives a Post-transcriptional Program to Promote Melanoma Invasion and Metastasis by Wurth, Laurence, Papasaikas, Panagiotis, Olmeda, David, Bley, Nadine, Calvo, Guadalupe T., Guerrero, Santiago, Cerezo-Wallis, Daniela, Martinez-Useros, Javier, García-Fernández, María, Hüttelmaier, Stefan, Soengas, Maria S., Gebauer, Fátima

“…RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma…”

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IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression by Hagemann, Sven, Misiak, Danny, Bell, Jessica L., Fuchs, Tommy, Lederer, Marcell I., Bley, Nadine, Hämmerle, Monika, Ghazy, Ehab, Sippl, Wolfgang, Schulte, Johannes H., Hüttelmaier, Stefan

“…Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma…”

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APOBEC3C‐mediated NF‐κB activation enhances clear cell renal cell carcinoma progression by Hase, Nora, Misiak, Danny, Taubert, Helge, Hüttelmaier, Stefan, Gekle, Michael, Köhn, Marcel

“…Renowned as the predominant form of kidney cancer, clear cell renal cell carcinoma (ccRCC) exhibits susceptibility to immunotherapies due to its specific…”

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IGF2BP1 is the first positive marker for anaplastic thyroid carcinoma diagnosis by Haase, Jacob, Misiak, Danny, Bauer, Marcus, Pazaitis, Nikolaos, Braun, Juliane, Pötschke, Rebecca, Mensch, Alexander, Bell, Jessica Lilian, Dralle, Henning, Siebolts, Udo, Wickenhauser, Claudia, Lorenz, Kerstin, Hüttelmaier, Stefan

“…Anaplastic thyroid carcinomas (ATC) are rare, but represent the most lethal malignancy of the thyroid. Selective molecular markers and drivers distinguishing…”

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NOP10 predicts lung cancer prognosis and its associated small nucleolar RNAs drive proliferation and migration by Cui, Chunhong, Liu, Yi, Gerloff, Dennis, Rohde, Christian, Pauli, Cornelius, Köhn, Marcel, Misiak, Danny, Oellerich, Thomas, Schwartz, Schraga, Schmidt, Lars-Henning, Wiewrodt, Rainer, Marra, Alessandro, Hillejan, Ludger, Bartel, Frank, Wickenhauser, Claudia, Hüttelmaier, Stefan, Göllner, Stefanie, Zhou, Fengbiao, Edemir, Bayram, Müller-Tidow, Carsten

“…Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide underlining the urgent need for new biomarkers and therapeutic targets for…”

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POLIII-derived non-coding RNAs acting as scaffolds and decoys by Täuber, Hendrik, Hüttelmaier, Stefan, Köhn, Marcel

“…A large variety of eukaryotic small structured POLIII-derived non-coding RNAs (ncRNAs) have been described in the past. However, for only few, e.g. 7SL and…”

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Effects of theophylline on ADCY5 activation—From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients by Tänzler, Dirk, Kipping, Marc, Lederer, Marcell, Günther, Wiebke F., Arlt, Christian, Hüttelmaier, Stefan, Merkenschlager, Andreas, Sinz, Andrea

“…We show the effects of the three purine derivatives, caffeine, theophylline, and istradefylline, on cAMP production by adenylyl cyclase 5…”

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