Mutant NPM1 Maintains the Leukemic State through HOX Expression
Brunetti, Lorenzo, Gundry, Michael C., Sorcini, Daniele, Guzman, Anna G., Huang, Yung-Hsin, Ramabadran, Raghav, Gionfriddo, Ilaria, Mezzasoma, Federica, Milano, Francesca, Nabet, Behnam, Buckley, Dennis L., Kornblau, Steven M., Lin, Charles Y., Sportoletti, Paolo, Martelli, Maria Paola, Falini, Brunangelo, Goodell, Margaret A.
Published in Cancer cell (10.09.2018)
Published in Cancer cell (10.09.2018)
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DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
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Published in Nature genetics (01.09.2016)
Published in Nature genetics (01.09.2016)
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Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
Jeong, Mira, Park, Hyun Jung, Celik, Hamza, Ostrander, Elizabeth L., Reyes, Jaime M., Guzman, Anna, Rodriguez, Benjamin, Lei, Yong, Lee, Yeojin, Ding, Lei, Guryanova, Olga A., Li, Wei, Goodell, Margaret A., Challen, Grant A.
Published in Cell reports (Cambridge) (03.04.2018)
Published in Cell reports (Cambridge) (03.04.2018)
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DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells
Gu, Tianpeng, Lin, Xueqiu, Cullen, Sean M, Luo, Min, Jeong, Mira, Estecio, Marcos, Shen, Jianjun, Hardikar, Swanand, Sun, Deqiang, Su, Jianzhong, Rux, Danielle, Guzman, Anna, Lee, Minjung, Qi, Lei Stanley, Chen, Jia-Jia, Kyba, Michael, Huang, Yun, Chen, Taiping, Li, Wei, Goodell, Margaret A
Published in Genome Biology (12.07.2018)
Published in Genome Biology (12.07.2018)
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The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development
Gu, Tianpeng, Hao, Dapeng, Woo, Junsung, Huang, Teng-Wei, Guo, Lei, Lin, Xueqiu, Guzman, Anna G, Tovy, Ayala, Rosas, Carina, Jeong, Mira, Zhou, Yubin, Deneen, Benjamin, Huang, Yun, Li, Wei, Goodell, Margaret A
Published in Nature genetics (01.05.2022)
Published in Nature genetics (01.05.2022)
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A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
Guo, Lei, Li, Jia, Zeng, Hongxiang, Guzman, Anna G, Li, Tingting, Lee, Minjung, Zhou, Yubin, Goodell, Margaret A, Stephan, Clifford, Davies, Peter J A, Dawson, Mark A, Sun, Deqiang, Huang, Yun
Published in Nature communications (06.02.2020)
Published in Nature communications (06.02.2020)
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Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies
Zeng, Hongxiang, He, Hailan, Guo, Lei, Li, Jia, Lee, Minjung, Han, Wei, Guzman, Anna G., Zang, Shengbing, Zhou, Yubin, Zhang, Xiaotian, Goodell, Margaret A., King, Katherine Y., Sun, Deqiang, Huang, Yun
Published in Cancer letters (28.12.2019)
Published in Cancer letters (28.12.2019)
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Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome
Tovy, Ayala, Rosas, Carina, Gaikwad, Amos S, Medrano, Geraldo, Zhang, Linda, Reyes, Jaime M, Huang, Yung-Hsin, Arakawa, Tastuhiko, Kurtz, Kristen, Conneely, Shannon E, Guzman, Anna G, Aguilar, Rogelio, Gao, Anne, Chen, Chun-Wei, Kim, Jean J, Carter, Melissa T, Lasa-Aranzasti, Amaia, Valenzuela, Irene, Van Maldergem, Lionel, Brunetti, Lorenzo, Hicks, M John, Marcogliese, Andrea N, Goodell, Margaret A, Rau, Rachel E
Published in Haematologica (Roma) (01.04.2022)
Published in Haematologica (Roma) (01.04.2022)
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DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells
Ramabadran, Raghav, Wang, Jarey H, Reyes, Jaime M, Guzman, Anna G, Gupta, Sinjini, Rosas, Carina, Brunetti, Lorenzo, Gundry, Michael C, Tovy, Ayala, Long, Hali, Gu, Tianpeng, Cullen, Sean M, Tyagi, Siddhartha, Rux, Danielle, Kim, Jean J, Kornblau, Steven M, Kyba, Michael, Stossi, Fabio, Rau, Rachel E, Takahashi, Koichi, Westbrook, Thomas F, Goodell, Margaret A
Published in Nature cell biology (01.04.2023)
Published in Nature cell biology (01.04.2023)
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Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis
Zhang, Xiaotian, Wang, Xinyu, Wang, Xue Qing David, Su, Jianzhong, Putluri, Nagireddy, Zhou, Ting, Qu, Ying, Jeong, Mira, Guzman, Anna, Rosas, Carina, Huang, Yun, Sreekumar, Arun, Li, Wei, Goodell, Margaret A.
Published in Blood (12.03.2020)
Published in Blood (12.03.2020)
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Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice
Sportoletti, Paolo, Sorcini, Daniele, Guzman, Anna G, Reyes, Jaime M, Stella, Arianna, Marra, Andrea, Sartori, Sara, Brunetti, Lorenzo, Rossi, Roberta, Del Papa, Beatrice, Adamo, Francesco, Pianigiani, Giulia, Betti, Camilla, Scialdone, Annarita, Spinozzi, Giulio, Tini, Valentina, Guarente, Valerio
Published in Leukemia (01.07.2021)
Published in Leukemia (01.07.2021)
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Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion
Tovy, Ayala, Reyes, Jaime M., Gundry, Michael C., Brunetti, Lorenzo, Lee-Six, Henry, Petljak, Mia, Park, Hyun Jung, Guzman, Anna G., Rosas, Carina, Jeffries, Aaron R., Baple, Emma, Mill, Jonathan, Crosby, Andrew H., Sency, Valerie, Xin, Baozhong, Machado, Heather E., Castillo, Danielle, Weitzel, Jeffrey N., Li, Wei, Stratton, Michael R., Campbell, Peter J., Wang, Heng, Sanders, Mathijs A., Goodell, Margaret A.
Published in Cell stem cell (06.08.2020)
Published in Cell stem cell (06.08.2020)
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SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells
Zhang, Linda, Hsu, Joanne I, Braekeleer, Etienne D, Chen, Chun-Wei, Patel, Tajhal D, Martell, Alejandra G, Guzman, Anna G, Wohlan, Katharina, Waldvogel, Sarah M, Uryu, Hidetaka, Tovy, Ayala, Callen, Elsa, Murdaugh, Rebecca L, Richard, Rosemary, Jansen, Sandra, Vissers, Lisenka, de Vries, Bert BA, Nussenzweig, Andre, Huang, Shixia, Coarfa, Cristian, Anastas, Jamie, Takahashi, Koichi, Vassiliou, George, Goodell, Margaret A
Published in eLife (18.06.2024)
Published in eLife (18.06.2024)
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Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis
Tovy, Ayala, Reyes, Jaime M, Zhang, Linda, Huang, Yung-Hsin, Rosas, Carina, Daquinag, Alexes C, Guzman, Anna, Ramabadran, Raghav, Chen, Chun-Wei, Gu, Tianpeng, Gupta, Sinjini, Ortinau, Laura, Park, Dongsu, Cox, Aaron R, Rau, Rachel E, Hartig, Sean M, Kolonin, Mikhail G, Goodell, Margaret A
Published in eLife (30.05.2022)
Published in eLife (30.05.2022)
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Autophagic signaling promotes systems-wide remodeling in skeletal muscle upon oncometabolic stress by D2-HG
Gao, Yaqi, Kim, Kyoungmin, Vitrac, Heidi, Salazar, Rebecca L., Gould, Benjamin D., Soedkamp, Daniel, Spivia, Weston, Raedschelders, Koen, Dinh, An Q., Guzman, Anna G., Tan, Lin, Azinas, Stavros, Taylor, David J.R., Schiffer, Walter, McNavish, Daniel, Burks, Helen B., Gottlieb, Roberta A., Lorenzi, Philip L., Hanson, Blake M., Van Eyk, Jennifer E., Taegtmeyer, Heinrich, Karlstaedt, Anja
Published in Molecular metabolism (Germany) (01.08.2024)
Published in Molecular metabolism (Germany) (01.08.2024)
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Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation
Reyes, Jaime M., Tovy, Ayala, Zhang, Linda, Bortoletto, Angelina S., Rosas, Carina, Chen, Chun-Wei, Waldvogel, Sarah M., Guzman, Anna G., Aguilar, Rogelio, Gupta, Sinjini, Liu, Ling, Buckley, Matthew T., Patel, Kalyani R., Marcogliese, Andrea N., Li, Yumei, Curry, Choladda V., Rando, Thomas A., Brunet, Anne, Parchem, Ronald J., Rau, Rachel E., Goodell, Margaret A.
Published in iScience (15.03.2024)
Published in iScience (15.03.2024)
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Posterior Rhabdosphincter Reconstruction During Robotic Assisted Radical Prostatectomy: Results From a Phase II Randomized Clinical Trial
Sutherland, Douglas E, Linder, Brian, Guzman, Anna M, Hong, Mark, Frazier, Harold A, Engel, Jason D, Bianco, Fernando J
Published in The Journal of urology (01.04.2011)
Published in The Journal of urology (01.04.2011)
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Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation
Reyes, Jaime M., Tovy, Ayala, Zhang, Linda, Bortoletto, Angelina S., Rosas, Carina, Chen, Chun-Wei, Waldvogel, Sarah M., Guzman, Anna G., Aguilar, Rogelio, Gupta, Sinjini, Liu, Ling, Buckley, Matthew T., Patel, Kalyani R., Marcogliese, Andrea N., Li, Yumei, Curry, Choladda V., Rando, Thomas A., Brunet, Anne, Parchem, Ronald J., Rau, Rachel E., Goodell, Margaret A.
Published in iScience (19.07.2024)
Published in iScience (19.07.2024)
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