Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing
Sánchez‐Martínez, Diego, Gutiérrez‐Agüera, Francisco, Romecin, Paola, Vinyoles, Meritxell, Palomo, Marta, Tirado, Néstor, Zanetti, Samanta Romina, Juan, Manel, Carlet, Michela, Jeremias, Irmela, Menéndez, Pablo
Published in Clinical and translational medicine (01.02.2021)
Published in Clinical and translational medicine (01.02.2021)
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Journal Article
Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells
Velasco‐Hernandez, Talia, Trincado, Juan L., Vinyoles, Meritxell, Closa, Adria, Martínez‐Moreno, Alba, Gutiérrez‐Agüera, Francisco, Molina, Oscar, Rodríguez‐Cortez, Virginia C., Ximeno‐Parpal, Pau, Fernández‐Fuentes, Narcís, Petazzi, Paolo, Beneyto‐Calabuig, Sergi, Velten, Lars, Romecin, Paola, Casquero, Raquel, Abollo‐Jiménez, Fernando, Guardia, Rafael D., Lorden, Patricia, Bataller, Alex, Lapillonne, Hélène, Stam, Ronald W., Vives, Susana, Torrebadell, Montserrat, Fuster, Jose L., Bueno, Clara, Sarry, Jean‐Emmanuel, Eyras, Eduardo, Heyn, Holger, Menéndez, Pablo
Published in HemaSphere (01.02.2024)
Published in HemaSphere (01.02.2024)
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A Benchmark Side-by-Side Comparison of Two Well-Established Protocols for in vitro Hematopoietic Differentiation From Human Pluripotent Stem Cells
Gutierrez-Agüera, Francisco, Rodriguez-Cortez, Virginia, Petazzi, Paolo, Bueno, Clara, Menendez, Pablo
Published in Frontiers in cell and developmental biology (21.05.2021)
Published in Frontiers in cell and developmental biology (21.05.2021)
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Journal Article
Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia
Sánchez Martínez, Diego, Tirado, Néstor, Mensurado, Sofia, Martínez-Moreno, Alba, Romecín, Paola, Gutiérrez Agüera, Francisco, Correia, Daniel V, Silva-Santos, Bruno, Menéndez, Pablo
Published in Journal for immunotherapy of cancer (01.09.2022)
Published in Journal for immunotherapy of cancer (01.09.2022)
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Journal Article
Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia
Tejedor, Juan Ramón, Bueno, Clara, Vinyoles, Meritxell, Petazzi, Paolo, Agraz-Doblas, Antonio, Cobo, Isabel, Torres-Ruiz, Raúl, Bayón, Gustavo F, Pérez, Raúl F, López-Tamargo, Sara, Gutierrez-Agüera, Francisco, Santamarina-Ojeda, Pablo, Ramírez-Orellana, Manuel, Bardini, Michela, Cazzaniga, Giovanni, Ballerini, Paola, Schneider, Pauline, Stam, Ronald W, Varela, Ignacio, Fraga, Mario F, Fernández, Agustín F, Menéndez, Pablo
Published in The Journal of clinical investigation (01.07.2021)
Published in The Journal of clinical investigation (01.07.2021)
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Journal Article
The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells
Rodriguez-Cortez, Virginia C, Navarrete-Meneses, Maria Pilar, Molina, Oscar, Velasco-Hernandez, Talia, Gonzalez, Jessica, Romecin, Paola, Gutierrez-Aguera, Francisco, Roca-Ho, Heleia, Vinyoles, Meritxell, Kowarz, Eric, Marin, Pedro, Rodriguez-Perales, Sandra, Gomez-Marin, Carlos, Perez-Vera, Patricia, Cortes-Ledesma, Felipe, Bigas, Anna, Terron, Andrea, Bueno, Clara, Menendez, Pablo
Published in Haematologica (Roma) (01.02.2022)
Published in Haematologica (Roma) (01.02.2022)
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Journal Article
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
Bueno, Clara, Calero-Nieto, Fernando J, Wang, Xiaonan, Valdés-Mas, Rafael, Gutiérrez-Agüera, Francisco, Roca-Ho, Heleia, Ayllon, Veronica, Real, Pedro J, Arambilet, David, Espinosa, Lluis, Torres-Ruiz, Raul, Agraz-Doblas, Antonio, Varela, Ignacio, de Boer, Jasper, Bigas, Anna, Gottgens, Bertie, Marschalek, Rolf, Menendez, Pablo
Published in Haematologica (Roma) (01.06.2019)
Published in Haematologica (Roma) (01.06.2019)
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Journal Article
Bone marrow mesenchymal stem/stromal cells from risk-stratified acute myeloid leukemia patients are anti-inflammatory in in vivo preclinical models of hematopoietic reconstitution and severe colitis
de la Guardia, Rafael Diaz, Lopez-Millan, Belen, Roca-Ho, Heleia, Bueno, Clara, Gutiérrez-Agüera, Francisco, Fuster, Jose Luis, Anguita, Eduardo, Zanetti, Samanta Romina, Vives, Susana, Nomdedeu, Josep, Sackstein, Robert, Lavoie, Jessie, Gónzalez-Rey, Elena, Delgado, Mario, Rosu-Myles, Michael, Menendez, Pablo
Published in Haematologica (Roma) (01.02.2019)
Published in Haematologica (Roma) (01.02.2019)
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Journal Article
The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia
Lopez-Millan, Belen, Costales, Paula, Gutiérrez-Agüera, Francisco, Díaz de la Guardia, Rafael, Roca-Ho, Heleia, Vinyoles, Meritxell, Rubio-Gayarre, Alba, Safi, Rémi, Castaño, Julio, Romecín, Paola Alejandra, Ramírez-Orellana, Manuel, Anguita, Eduardo, Jeremias, Irmela, Zamora, Lurdes, Rodríguez-Manzaneque, Juan Carlos, Bueno, Clara, Morís, Francisco, Menendez, Pablo
Published in Cancers (21.03.2022)
Published in Cancers (21.03.2022)
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Journal Article
Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells
Petazzi, Paolo, Torres-Ruiz, Raul, Fidanza, Antonella, Roca-Ho, Heleia, Gutierrez-Agüera, Francisco, Castaño, Julio, Rodriguez-Perales, Sandra, Díaz de la Guardia, Rafael, López-Millán, Belén, Bigas, Anna, Forrester, Lesley M., Bueno, Clara, Menéndez, Pablo
Published in Molecular therapy. Nucleic acids (05.06.2020)
Published in Molecular therapy. Nucleic acids (05.06.2020)
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Journal Article
IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q- AML
Lopez-Millan, Belen, Diaz de la Guardia, Rafael, Roca-Ho, Heleia, Anguita, Eduardo, Islam, Abul B. M. M. K., Romero-Moya, Damia, Prieto, Cristina, Gutierrez-Agüera, Francisco, Bejarano-Garcia, Jose Antonio, Perez-Simon, Jose Antonio, Costales, Paula, Rovira, Montse, Marín, Pedro, Menendez, Silvia, Iglesias, Mar, Fuster, Jose Luis, Urbano-Ispizua, Alvaro, Anjos-Afonso, Fernando, Bueno, Clara, Menendez, Pablo
Published in Oncoimmunology (02.09.2018)
Published in Oncoimmunology (02.09.2018)
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Journal Article
Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia
Sánchez-Martínez, Diego, Baroni, Matteo L., Gutierrez-Agüera, Francisco, Roca-Ho, Heleia, Blanch-Lombarte, Oscar, González-García, Sara, Torrebadell, Montserrat, Junca, Jordi, Ramírez-Orellana, Manuel, Velasco-Hernández, Talía, Bueno, Clara, Fuster, José Luís, Prado, Julia G., Calvo, Julien, Uzan, Benjamin, Cools, Jan, Camos, Mireia, Pflumio, Françoise, Toribio, María Luisa, Menéndez, Pablo
Published in Blood (23.05.2019)
Published in Blood (23.05.2019)
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Journal Article
A novel and efficient tandem CD19- and CD22-directed CAR for B cell ALL
Zanetti, Samanta Romina, Velasco-Hernandez, Talia, Gutierrez-Agüera, Francisco, Díaz, Víctor M., Romecín, Paola Alejandra, Roca-Ho, Heleia, Sánchez-Martínez, Diego, Tirado, Néstor, Baroni, Matteo Libero, Petazzi, Paolo, Torres-Ruiz, Raúl, Molina, Oscar, Bataller, Alex, Fuster, José Luis, Ballerini, Paola, Juan, Manel, Jeremias, Irmela, Bueno, Clara, Menéndez, Pablo
Published in Molecular therapy (02.02.2022)
Published in Molecular therapy (02.02.2022)
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Journal Article
NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia
Lopez-Millan, Belen, Sanchéz-Martínez, Diego, Roca-Ho, Heleia, Gutiérrez-Agüera, Francisco, Molina, Oscar, Diaz de la Guardia, Rafael, Torres-Ruiz, Raúl, Fuster, Jose Luís, Ballerini, Paola, Suessbier, Ute, Nombela-Arrieta, Cesar, Bueno, Clara, Menéndez, Pablo
Published in Leukemia (01.07.2019)
Published in Leukemia (01.07.2019)
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Journal Article
CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity
Bueno, Clara, Velasco-Hernandez, Talia, Gutiérrez-Agüera, Francisco, Zanetti, Samanta Romina, Baroni, Matteo L, Sánchez-Martínez, Diego, Molina, Oscar, Closa, Adria, Agraz-Doblás, Antonio, Marín, Pedro, Eyras, Eduardo, Varela, Ignacio, Menéndez, Pablo
Published in Leukemia (01.08.2019)
Published in Leukemia (01.08.2019)
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Journal Article
CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies
Bueno, Clara, Barrera, Susana, Bataller, Alex, Ortiz-Maldonado, Valentín, Elliot, Natalina, O'Byrne, Sorcha, Wang, Guanlin, Rovira, Montse, Gutierrez-Agüera, Francisco, Trincado, Juan L, González-González, María, Morgades, Mireia, Sorigué, Marc, Bárcena, Paloma, Zanetti, Samanta Romina, Torrebadell, Montse, Vega-Garcia, Nerea, Rives, Susana, Mallo, Mar, Sole, Francesc, Mead, Adam J, Roberts, Irene, Thongjuea, Supat, Psaila, Bethan, Juan, Manel, Delgado, Julio, Urbano-Ispizúa, Alvaro, Ribera, Josep María, Orfao, Alberto, Roy, Anindita, Menendez, Pablo
Published in Blood (07.07.2022)
Published in Blood (07.07.2022)
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Journal Article
Titin Missense Variants as a Cause of Familial Dilated Cardiomyopathy
Domínguez, Fernando, Lalaguna, Laura, Martínez-Martín, Inés, Piqueras-Flores, Jesús, Rasmussen, Torsten Bloch, Zorio, Esther, Giovinazzo, Giovanna, Prados, Belen, Ochoa, Juan Pablo, Bornstein, Belen, González-López, Esther, Velázquez-Carreras, Diana, Pricolo, Maria Rosaria, Gutiérrez-Agüera, Francisco, Bernal, Juan Antonio, Herrero-Galán, Elías, Alegre-Cebollada, Jorge, Lara-Pezzi, Enrique, García-Pavía, Pablo
Published in Circulation (New York, N.Y.) (30.05.2023)
Published in Circulation (New York, N.Y.) (30.05.2023)
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Journal Article
Impaired condensin complex and Aurora B kinase underlie mitotic and chromosomal defects in hyperdiploid B-cell ALL
Molina, Oscar, Vinyoles, Meritxell, Granada, Isabel, Roca-Ho, Heleia, Gutierrez-Agüera, Francisco, Valledor, Luis, López-López, Carlos M., Rodríguez-González, Pablo, Trincado, Juan L., Menéndez, Sofía T., Pal, Deepali, Ballerini, Paola, den Boer, Monique L., Plensa, Isabel, Mar Perez-Iribarne, M., Rodríguez-Perales, Sandra, Calasanz, María José, Ramírez-Orellana, Manuel, Rodríguez, René, Camós, Mireia, Calvo, Maria, Bueno, Clara, Menéndez, Pablo
Published in Blood (16.07.2020)
Published in Blood (16.07.2020)
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Journal Article
41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo
Baroni, Matteo Libero, Sanchez Martinez, Diego, Gutierrez Aguera, Francisco, Roca Ho, Heleia, Castella, Maria, Zanetti, Samanta Romina, Velasco Hernandez, Talia, Diaz de la Guardia, Rafael, Castaño, Julio, Anguita, Eduardo, Vives, Susana, Nomdedeu, Josep, Lapillone, Helene, Bras, Anne E, van der Velden, Vincent H J, Junca, Jordi, Marin, Pedro, Bataller, Alex, Esteve, Jordi, Vick, Binje, Jeremias, Irmela, Lopez, Angel, Sorigue, Marc, Bueno, Clara, Menendez, Pablo
Published in Journal for immunotherapy of cancer (01.06.2020)
Published in Journal for immunotherapy of cancer (01.06.2020)
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Journal Article
Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers
Blanco, Belén, Ramírez-Fernández, Ángel, Bueno, Clara, Argemí-Muntadas, Lidia, Fuentes, Patricia, Aguilar-Sopeña, Óscar, Gutierrez-Agüera, Francisco, Zanetti, Samanta Romina, Tapia-Galisteo, Antonio, Díez-Alonso, Laura, Segura-Tudela, Alejandro, Castellà, Maria, Marzal, Berta, Betriu, Sergi, Harwood, Seandean L, Compte, Marta, Lykkemark, Simon, Erce-Llamazares, Ainhoa, Rubio-Pérez, Laura, Jiménez-Reinoso, Anaïs, Domínguez-Alonso, Carmen, Neves, Maria, Morales, Pablo, Paz-Artal, Estela, Guedan, Sonia, Sanz, Laura, Toribio, María L, Roda-Navarro, Pedro, Juan, Manel, Menéndez, Pablo, Álvarez-Vallina, Luis
Published in Cancer immunology research (01.04.2022)
Published in Cancer immunology research (01.04.2022)
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