Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes
Ribeiro, Alexandre J. S., Guth, Brian D., Engwall, Michael, Eldridge, Sandy, Foley, C. Michael, Guo, Liang, Gintant, Gary, Koerner, John, Parish, Stanley T., Pierson, Jennifer B., Brock, Mathew, Chaudhary, Khuram W., Kanda, Yasunari, Berridge, Brian
Published in Frontiers in pharmacology (29.08.2019)
Published in Frontiers in pharmacology (29.08.2019)
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Journal Article
Effects of isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl on physiological variables continuously measured by telemetry in Wistar rats
Albrecht, Maike, Henke, Julia, Tacke, Sabine, Markert, Michael, Guth, Brian
Published in BMC veterinary research (23.08.2014)
Published in BMC veterinary research (23.08.2014)
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Journal Article
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies
Alizadeh, Elham Ataei, Trautmann, Thomas, Krause, Florian, Knoeferl, Benjamin, Guns, Pieter-Jan, De Meyer, Guido, Guth, Brian D., Markert, Michael
Published in Journal of pharmacological and toxicological methods (01.05.2023)
Published in Journal of pharmacological and toxicological methods (01.05.2023)
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Journal Article
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization
Alizadeh, Elham Ataei, Graf, Karin, Schiwon, Jessica, Trautmann, Thomas, Krause, Florian, Mayer, Werner, Christ, Katrin, Martel, Eric, Guth, Brian D., Markert, Michael
Published in Journal of pharmacological and toxicological methods (01.07.2023)
Published in Journal of pharmacological and toxicological methods (01.07.2023)
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Journal Article
Optimization of bioanalysis of dried blood samples
Alizadeh, Elham Ataei, Rast, Georg, Cantow, Chris, Schiwon, Jessica, Krause, Florian, De Meyer, Guido R.Y., Guns, Pieter-Jan, Guth, Brian D., Markert, Michael
Published in Journal of pharmacological and toxicological methods (01.09.2023)
Published in Journal of pharmacological and toxicological methods (01.09.2023)
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Journal Article
A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission
Markert, Michael, Trautmann, Thomas, Krause, Florian, Cioaga, Marius, Mouriot, Sebastien, Wetzel, Miriam, Guth, Brian D.
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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Journal Article
Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection
Rast, Georg, Kraushaar, Udo, Buckenmaier, Sandra, Ittrich, Carina, Guth, Brian D.
Published in Journal of pharmacological and toxicological methods (01.11.2016)
Published in Journal of pharmacological and toxicological methods (01.11.2016)
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Journal Article
An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes
Rast, Georg, Weber, Jürgen, Disch, Christoph, Schuck, Elmar, Ittrich, Carina, Guth, Brian D.
Published in Journal of pharmacological and toxicological methods (01.09.2015)
Published in Journal of pharmacological and toxicological methods (01.09.2015)
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Journal Article
The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium
Guth, Brian D., Chiang, Alan Y., Doyle, Jennifer, Engwall, Michael J., Guillon, Jean-Michel, Hoffmann, Peter, Koerner, John, Mittelstadt, Scott, Ottinger, Sean, Pierson, Jennifer Beck, Pugsley, Michael K., Rossman, Eric I., Walisser, Jacqueline, Sarazan, R. Dustan
Published in Journal of pharmacological and toxicological methods (01.09.2015)
Published in Journal of pharmacological and toxicological methods (01.09.2015)
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Journal Article
Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms
Guth, Brian D, Engwall, Michael, Eldridge, Sandy, Foley, C Michael, Guo, Liang, Gintant, Gary, Koerner, John, Parish, Stanley T, Pierson, Jennifer B, Ribeiro, Alexandre J S, Zabka, Tanja, Chaudhary, Khuram W, Kanda, Yasunari, Berridge, Brian
Published in Frontiers in pharmacology (09.08.2019)
Published in Frontiers in pharmacology (09.08.2019)
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Journal Article
GLP in safety pharmacology studies: Report card after 15years
Guth, Brian D., Pugsley, Michael K.
Published in Journal of pharmacological and toxicological methods (01.09.2017)
Published in Journal of pharmacological and toxicological methods (01.09.2017)
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Journal Article
Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium
Heller, Simon, FRCP, Darpö, Börje, MD, PhD, Mitchell, Malcolm I., MBBS, MFPM, Linnebjerg, Helle, PhD, Leishman, Derek J., PhD, DSP, Mehrotra, Nitin, PhD, Zhu, Hao, PhD, Koerner, John, PhD, Fiszman, Mónica L., MD, PhD, Balakrishnan, Suchitra, MD, PhD, Xiao, Shen, MD, PhD, Todaro, Thomas G., MD, JD, Hensley, Ingrid, PhD, Guth, Brian D., PhD, Michelson, Eric L., MD, FACC, Sager, Philip, MD, FACC, FAHA, FHRS
Published in The American heart journal (01.07.2015)
Published in The American heart journal (01.07.2015)
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Journal Article
INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology
Guns, Pieter-Jan D., Guth, Brian D., Braam, Stefan, Kosmidis, Georgios, Matsa, Elena, Delaunois, Annie, Gryshkova, Vitalina, Bernasconi, Sylvain, Knot, Harm J., Shemesh, Yair, Chen, Alon, Markert, Michael, Fernández, Miguel A., Lombardi, Damiano, Grandmont, Céline, Cillero-Pastor, Berta, Heeren, Ron M.A., Martinet, Wim, Woolard, Jeanette, Skinner, Matt, Segers, Vincent F.M., Franssen, Constantijn, Van Craenenbroeck, Emeline M., Volders, Paul G.A., Pauwelyn, Thomas, Braeken, Dries, Yanez, Paz, Correll, Krystle, Yang, Xi, Prior, Helen, Kismihók, Gábor, De Meyer, Guido R.Y., Valentin, Jean-Pierre
Published in Journal of pharmacological and toxicological methods (01.09.2020)
Published in Journal of pharmacological and toxicological methods (01.09.2020)
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Journal Article
Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa
Guth, Brian D., Grobler, Anne F., Frazier, Kendall S., Greiter-Wilke, Andrea, Herzyk, Danuta, Hough, Tertius A., Khan, Asrar Ali, Markert, Michael, Smith, James D., Svenson, Karen L., Wells, Sara, Pugsley, Michael K.
Published in Journal of pharmacological and toxicological methods (01.07.2019)
Published in Journal of pharmacological and toxicological methods (01.07.2019)
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Journal Article