Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib
Li, Yangfeng, Zhao, Jiong, Gutgesell, Lauren M, Shen, Zhengnan, Ratia, Kiira, Dye, Katherine, Dubrovskyi, Oleksii, Zhao, Huiping, Huang, Fei, Tonetti, Debra A, Thatcher, Gregory R. J, Xiong, Rui
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer
Xiong, Rui, Zhao, Jiong, Gutgesell, Lauren M, Wang, Yueting, Lee, Sue, Karumudi, Bhargava, Zhao, Huiping, Lu, Yunlong, Tonetti, Debra A, Thatcher, Gregory R. J
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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Journal Article
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer
Lu, Yunlong, Gutgesell, Lauren M, Xiong, Rui, Zhao, Jiong, Li, Yangfeng, Rosales, Carlo I, Hollas, Michael, Shen, Zhengnan, Gordon-Blake, Jesse, Dye, Katherine, Wang, Yueting, Lee, Sue, Chen, Hu, He, Donghong, Dubrovyskyii, Oleksii, Zhao, Huiping, Huang, Fei, Lasek, Amy W, Tonetti, Debra A, Thatcher, Gregory R. J
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Journal Article
G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer
Andreano, Kaitlyn J., Wardell, Suzanne E., Baker, Jennifer G., Desautels, Taylor K., Baldi, Robert, Chao, Christina A., Heetderks, Kendall A., Bae, Yeeun, Xiong, Rui, Tonetti, Debra A., Gutgesell, Lauren M., Zhao, Jiong, Sorrentino, Jessica A., Thompson, Delita A., Bisi, John E., Strum, Jay C., Thatcher, Gregory R. J., Norris, John D.
Published in Breast cancer research and treatment (01.04.2020)
Published in Breast cancer research and treatment (01.04.2020)
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Journal Article
Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer
Xiong, Rui, Patel, Hitisha K, Gutgesell, Lauren M, Zhao, Jiong, Delgado-Rivera, Loruhama, Pham, Thao N. D, Zhao, Huiping, Carlson, Kathryn, Martin, Teresa, Katzenellenbogen, John A, Moore, Terry W, Tonetti, Debra A, Thatcher, Gregory R. J
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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Journal Article
959 Multiomic characterization of the tumor microenvironment in FFPE tissue by simultaneous protein and gene expression profiling
Chiang, Jun, Santiago, Ace, Hermes, Alexander, Patel, Anuj, Veire, Benton, Sukovich, David, Singh, Hardeep, Gutgesell, Lauren, Williams, Stephen, Tentori, Augusto
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER plus Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib
Li, Yangfeng, Zhao, Jiong, Gutgesell, Lauren M., Shen, Zhengnan, Ratia, Kiira, Dye, Katherine, Dubrovskyi, Oleksii, Zhao, Huiping, Huang, Fei, Tonetti, Debra A., Thatcher, Gregory R. J., Xiong, Rui
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Guttman, Ofer, Le Thomas, Adrien, Marsters, Scot, Lawrence, David A, Gutgesell, Lauren, Zuazo-Gaztelu, Iratxe, Harnoss, Jonathan M, Haag, Simone M, Murthy, Aditya, Strasser, Geraldine, Modrusan, Zora, Wu, Thomas, Mellman, Ira, Ashkenazi, Avi
Published in The Journal of cell biology (06.06.2022)
Published in The Journal of cell biology (06.06.2022)
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Journal Article
Abstract 3744: Multiple endocrine-resistant breast cancer cell lines retain ER and sensitivity to endocrine therapy
Gutgesell, Lauren M., Xiong, Rui, Zhao, Jiong, Zhao, Huiping, Tonetti, Debra A., Thatcher, Gregory R.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 3738: Three-dimensional treatment-resistant breast cancer spheroids as a predictive model of in vivo response to endocrine therapy
Rosales, Carlo I., Zhao, Jiong, Gutgesell, Lauren M., Xiong, Rui, Tonetti, Debra A., Thatcher, Gregory R.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Efficacy, maximal tolerated dose, and toxicokinetics of TTC-352 in rats and dogs, a partial ER agonist for metastatic ER+ breast cancer
Tonetti, Debra A., Xiong, Rui, Zhao, Jiong, Gutgesell, Lauren, Dudek, Arkadiusz Z., Thatcher, Gregory R.
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
Abstract C98: Selective estrogen mimics (SEMs) for the treatment of tamoxifen resistant breast cancer
Patel, Hitisha, Xiong, Rui, Gutgesell, Lauren, Zhao, Jiong, Molloy, Mary Ellen, Tonetti, Debra, Thatcher, Gregory R.J
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Abstract 4708: Application of spatially resolved transcriptomics to screen multiple tumor biospecimens using tissue microarrays
Mohabbat, Syrus, Singh, Hardeep, Williams, Stephen R., Gutgesell, Lauren M M., Sukovich, David J., Kamath, Govinda M., Kim, Hanyoup, Janesick, Amanda, Shelansky, Robert, Beliakoff, Ghezal, Tentori, Augusto M., Kim, Albert, Uytingco, Cedric R., Taylor, Sarah
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
선택적인 에스트로겐 수용체 분해제로서의 치환된 벤조티오펜 유사체
XIONG RUI, ZHAO JIONG, LU YUNLONG, THATCHER GREGORY R, GUTGESELL LAUREN, LI YANFENG, ROSALES CARLO IVAN
Year of Publication 19.11.2020
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Year of Publication 19.11.2020
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