Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo
Hickman, John A, Graeser, Ralph, de Hoogt, Ronald, Vidic, Suzana, Brito, Catarina, Gutekunst, Matthias, van der Kuip, Heiko
Published in Biotechnology journal (01.09.2014)
Published in Biotechnology journal (01.09.2014)
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Journal Article
p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin
Gutekunst, Matthias, Oren, Moshe, Weilbacher, Andrea, Dengler, Michael A, Markwardt, Christiane, Thomale, Jürgen, Aulitzky, Walter E, van der Kuip, Heiko
Published in PloS one (21.04.2011)
Published in PloS one (21.04.2011)
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Journal Article
Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
GUTEKUNST, Matthias, MUELLER, Thomas, WEILBACHER, Andrea, DENGLER, Michael A, BEDKE, Jens, KRUCK, Stephan, OREN, Moshe, AULITZKY, Walter E, VAN DER KUIP, Heiko
Published in Cancer research (Chicago, Ill.) (01.03.2013)
Published in Cancer research (Chicago, Ill.) (01.03.2013)
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Journal Article
Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis
Dengler, Michael A, Staiger, Annette M, Gutekunst, Matthias, Hofmann, Ute, Doszczak, Malgorzata, Scheurich, Peter, Schwab, Matthias, Aulitzky, Walter E, van der Kuip, Heiko
Published in PloS one (20.09.2011)
Published in PloS one (20.09.2011)
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Journal Article
Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices
Davies, Emma J., Dong, Meng, Gutekunst, Matthias, Närhi, Katja, van Zoggel, Hanneke J. A. A., Blom, Sami, Nagaraj, Ashwini, Metsalu, Tauno, Oswald, Eva, Erkens-Schulze, Sigrun, Delgado San Martin, Juan A., Turkki, Riku, Wedge, Stephen R., af Hällström, Taija M., Schueler, Julia, van Weerden, Wytske M., Verschuren, Emmy W., Barry, Simon T., van der Kuip, Heiko, Hickman, John A.
Published in Scientific reports (09.12.2015)
Published in Scientific reports (09.12.2015)
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Journal Article
Abstract 8: Differential roles of OCT3/4, SOX2 and NANOG for constitutive high NOXA expression levels in embryonal carcinoma (EC) cells
Bayha, Christine, Gutekunst, Matthias, Aulitzky, Walter E., van der Kuip, Heiko
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Imatinib mesylate induces cisplatin hypersensitivity in Bcr-Abl+ cells by differential modulation of p53 transcriptional and proapoptotic activity
Skorta, Ioanna, Oren, Moshe, Markwardt, Christiane, Gutekunst, Matthias, Aulitzky, Walter E, van der Kuip, Heiko
Published in Cancer research (Chicago, Ill.) (15.12.2009)
Published in Cancer research (Chicago, Ill.) (15.12.2009)
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Journal Article
Abstract 1721: Testicular germ cell tumors are hypersensitive to p53 activation based on their Oct-4/Noxa-mediated cellular context rather than on differential p53 activity
Gutekunst, Matthias, Mueller, Thomas, Weilbacher, Andrea, Dengler, Michael A., Oren, Moshe, Aulitzky, Walter E., van der Kuip, Heiko
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
The Phenotype High Noxa mRNA/Low NOXA Protein Levels Constitutes a Critical Achilles Heel Of Mantle Cell Lymphoma (MCL) Cells
Dengler, Michael A., Weilbacher, Andrea, Gutekunst, Matthias, Staiger, Annette M., Horn, Heike, Ott, German, van der Kuip, Heiko, Aulitzky, Walter E.
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
Abstract 1717: High NOXA (PMAIP1) transcript levels combined with a short-lived NOXA protein primes mantle cell lymphoma (MCL) cells for death by inhibition of the ubiquitin proteasome system
Dengler, Michael A., Weilbacher, Andrea, Gutekunst, Matthias, Staiger, Annette M., Horn, Heike, Ott, German, van der Kuip, Heiko, Aulitzky, Walter E.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Abstract 4675: Fatty acid metabolism is a possible target for treatment of cyclin D1 over-expressing mantle cell lymphoma
Dengler, Michael A., Gutekunst, Matthias, Staiger, Annette M., Kopacz, Stephanie, Ott, German, van der Kuip, Heiko, Aulitzky, Walter E.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 2002: OCT-3/4 expression is associated with high levels of the pro-apoptotic BH3 only protein NOXA in testicular germ cell tumors (TGCTs)
Gutekunst, Matthias, Mueller, Thomas, Weilbacher, Andrea, Dengler, Michael A., Kruck, Stephan, Bedke, Jens, Aulitzky, Walter E., van der Kuip, Heiko
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 4693: High expression levels of NOXA are important for p53-mediated hypersensitivity in testicular germ cell tumor (TGCT) cells
Gutekunst, Matthias, Oren, Moshe, Weilbacher, Andrea, Dengler, Michael A., Aulitzky, Walter E., van der Kuip, Heiko
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Abstract 1266: Oncogenic stress induced by Bcr-Abl over-activation leads to cell death mediated by a massively enhanced aerobic glycolysis
Dengler, Michael A., Staiger, Annette, Gutekunst, Matthias, Hofmann, Ute, Aulitzky, Walter E., van der Kuip, Heiko
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Abstract 4522: Oncogenic stress-induced cell death following Imatinib deprivation in Bcr-Abl overexpressing Imatinib-resistant ALL cells
Dengler, Michael A., Staiger, Annette M., Gutekunst, Matthias, Aulitzky, Walter E., van der Kuip, Heiko
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Cyclin D1 Over-Expressing Mantle Cell Lymphoma Cells Are Hypersensitive to Inhibition of Fatty Acid Synthase (FASN)
Dengler, Michael A., Gutekunst, Matthias, Kopacz, Stephanie, Horn, Heike, Hofmann, Ute, Schwab, Matthias, Ott, German, van der Kuip, Heiko, Aulitzky, Walter E.
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Glucocorticoids Inhibit Cell Death Induced by Oncogenic Stress After Imatinib Withdrawal In TKI Resistant p190Bcr/Abl Overexpressing Cells
Dengler, Michael A., Staiger, Annette M., Hofmann, Ute, Gutekunst, Matthias, van der Kuip, Heiko, Aulitzky, Walter E.
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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