Effects of chronic inhibition of phosphodiesterase-4D on behavior and regional rates of cerebral protein synthesis in a mouse model of fragile X syndrome
Rosenheck, Michael, Sheeler, Carrie, Saré, Rachel Michelle, Gurney, Mark E., Smith, Carolyn Beebe
Published in Neurobiology of disease (01.11.2021)
Published in Neurobiology of disease (01.11.2021)
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Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury
Wilson, Nicole M, Gurney, Mark E, Dietrich, W Dalton, Atkins, Coleen M
Published in PloS one (19.05.2017)
Published in PloS one (19.05.2017)
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Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization
Wang, QuanQiu, Davis, Pamela B, Qi, Xin, Chen, Shu G, Gurney, Mark E, Perry, George, Doraiswamy, P Murali, Xu, Rong
Published in Alzheimer's research & therapy (20.10.2021)
Published in Alzheimer's research & therapy (20.10.2021)
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Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile X syndrome
Norris, Jordan E, Berry-Kravis, Elizabeth M, Harnett, Mark D, Reines, Scott A, Reese, Melody A, Outterson, Abigail H, Michalak, Claire, Furman, Jeremiah, Gurney, Mark E, Ethridge, Lauren E
Published in Molecular autism (02.11.2024)
Published in Molecular autism (02.11.2024)
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The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
Stefansson, Kari, Helgadottir, Anna, Manolescu, Andrei, Thorleifsson, Gudmar, Gretarsdottir, Solveig, Jonsdottir, Helga, Thorsteinsdottir, Unnur, Samani, Nilesh J, Gudmundsson, Gudmundur, Grant, Struan F A, Thorgeirsson, Gudmundur, Sveinbjornsdottir, Sigurlaug, Valdimarsson, Einar M, Matthiasson, Stefan E, Johannsson, Halldor, Gudmundsdottir, Olof, Gurney, Mark E, Sainz, Jesus, Thorhallsdottir, Margret, Andresdottir, Margret, Frigge, Michael L, Topol, Eric J, Kong, Augustine, Gudnason, Vilmundur, Hakonarson, Hakon, Gulcher, Jeffrey R
Published in Nature genetics (01.03.2004)
Published in Nature genetics (01.03.2004)
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A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway
Wang, Yulu, Gao, Shichao, Zheng, Victor, Chen, Ling, Ma, Min, Shen, Shichen, Qu, Jun, Zhang, Hanting, Gurney, Mark E, O'Donnell, James M, Xu, Ying
Published in Frontiers in cell and developmental biology (10.12.2020)
Published in Frontiers in cell and developmental biology (10.12.2020)
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Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy
Butchbach, Matthew E.R., Singh, Jasbir, Þorsteinsdóttir, Margrét, Saieva, Luciano, Slominski, Elzbieta, Thurmond, John, Andrésson, Thorkell, Zhang, Jun, Edwards, Jonathan D., Simard, Louise R., Pellizzoni, Livio, Jarecki, Jill, Burghes, Arthur H.M., Gurney, Mark E.
Published in Human molecular genetics (01.02.2010)
Published in Human molecular genetics (01.02.2010)
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COVID‐19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US
Wang, QuanQiu, Davis, Pamela B., Gurney, Mark E., Xu, Rong
Published in Alzheimer's & Dementia (01.08.2021)
Published in Alzheimer's & Dementia (01.08.2021)
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Formation of High Molecular Weight Complexes of Mutant Cu,Zn-Superoxide Dismutase in a Mouse Model for Familial Amyotrophic Lateral Sclerosis
Johnston, Jennifer A., Dalton, Muffie J., Gurney, Mark E., Kopito, Ron R.
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2000)
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DcpS as a Therapeutic Target for Spinal Muscular Atrophy
Singh, Jasbir, Salcius, Michael, Liu, Shin-Wu, Staker, Bart L, Mishra, Rama, Thurmond, John, Michaud, Gregory, Mattoon, Dawn R, Printen, John, Christensen, Jeffery, Bjornsson, Jon Mar, Pollok, Brian A, Kiledjian, Megerditch, Stewart, Lance, Jarecki, Jill, Gurney, Mark E
Published in ACS chemical biology (21.11.2008)
Published in ACS chemical biology (21.11.2008)
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Synthesis and Biological Evaluation of Novel 2,4-Diaminoquinazoline Derivatives as SMN2 Promoter Activators for the Potential Treatment of Spinal Muscular Atrophy
Thurmond, John, Butchbach, Matthew E. R, Palomo, Marty, Pease, Brian, Rao, Munagala, Bedell, Louis, Keyvan, Monica, Pai, Grace, Mishra, Rama, Haraldsson, Magnus, Andresson, Thorkell, Bragason, Gisli, Thosteinsdottir, Margret, Bjornsson, Jon Mar, Coovert, Daniel D, Burghes, Arthur H. M, Gurney, Mark E, Singh, Jasbir
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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PDE4 subtypes in cancer
Hsien Lai, Samuel, Zervoudakis, Guston, Chou, Jesse, Gurney, Mark E., Quesnelle, Kelly M.
Published in Oncogene (07.05.2020)
Published in Oncogene (07.05.2020)
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Journal Article
Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial
Berry-Kravis, Elizabeth M., Harnett, Mark D., Reines, Scott A., Reese, Melody A., Ethridge, Lauren E., Outterson, Abigail H., Michalak, Claire, Furman, Jeremiah, Gurney, Mark E.
Published in Nature medicine (01.05.2021)
Published in Nature medicine (01.05.2021)
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The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies
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