Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph
Published in Nature medicine (01.05.2018)
Published in Nature medicine (01.05.2018)
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Journal Article
PD1 Expression in EGFRvIII-Directed CAR T Cell Infusion Product for Glioblastoma Is Associated with Clinical Response
Tang, Oliver Y, Tian, Lifeng, Yoder, Todd, Xu, Rong, Kulikovskaya, Irina, Gupta, Minnal, Melenhorst, Jan Joseph, Lacey, Simon F, O'Rourke, Donald M, Binder, Zev A
Published in Frontiers in immunology (06.05.2022)
Published in Frontiers in immunology (06.05.2022)
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Journal Article
Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphoma
Panjwani, M. Kazim, Atherton, Matthew J., MaloneyHuss, Martha A., Haran, Kumudhini P., Xiong, Ailian, Gupta, Minnal, Kulikovsaya, Irina, Lacey, Simon F., Mason, Nicola J.
Published in Oncoimmunology (01.01.2020)
Published in Oncoimmunology (01.01.2020)
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Journal Article
Evaluating the skin in patients undergoing chimeric antigen receptor modified T-cell therapy
Rubin, Courtney B., MD, Elenitsas, Rosalie, MD, Taylor, Laura, MD, Lacey, Simon F., PhD, Kulikovskaya, Irina, MSc, MB(ASCP)CM, Gupta, Minnal, MSc, Melenhorst, Jan J., PhD, Loren, Alison, MD, MS, Frey, Noelle, MD, MSCE, June, Carl H., MD, Porter, David, MD, Rosenbach, Misha, MD
Published in Journal of the American Academy of Dermatology (01.11.2016)
Published in Journal of the American Academy of Dermatology (01.11.2016)
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Journal Article
Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph
Published in Nature medicine (01.03.2021)
Published in Nature medicine (01.03.2021)
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Journal Article
Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
Melenhorst, J. Joseph, Chen, Gregory M., Wang, Meng, Porter, David L., Chen, Changya, Collins, McKensie A., Gao, Peng, Bandyopadhyay, Shovik, Sun, Hongxing, Zhao, Ziran, Lundh, Stefan, Pruteanu-Malinici, Iulian, Nobles, Christopher L., Maji, Sayantan, Frey, Noelle V., Gill, Saar I., Loren, Alison W., Tian, Lifeng, Kulikovskaya, Irina, Gupta, Minnal, Ambrose, David E., Davis, Megan M., Fraietta, Joseph A., Brogdon, Jennifer L., Young, Regina M., Chew, Anne, Levine, Bruce L., Siegel, Donald L., Alanio, Cécile, Wherry, E. John, Bushman, Frederic D., Lacey, Simon F., Tan, Kai, June, Carl H.
Published in Nature (London) (17.02.2022)
Published in Nature (London) (17.02.2022)
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Journal Article
CRISPR-engineered T cells in patients with refractory cancer
Stadtmauer, Edward A, Fraietta, Joseph A, Davis, Megan M, Cohen, Adam D, Weber, Kristy L, Lancaster, Eric, Mangan, Patricia A, Kulikovskaya, Irina, Gupta, Minnal, Chen, Fang, Tian, Lifeng, Gonzalez, Vanessa E, Xu, Jun, Jung, In-Young, Melenhorst, J Joseph, Plesa, Gabriela, Shea, Joanne, Matlawski, Tina, Cervini, Amanda, Gaymon, Avery L, Desjardins, Stephanie, Lamontagne, Anne, Salas-Mckee, January, Fesnak, Andrew, Siegel, Donald L, Levine, Bruce L, Jadlowsky, Julie K, Young, Regina M, Chew, Anne, Hwang, Wei-Ting, Hexner, Elizabeth O, Carreno, Beatriz M, Nobles, Christopher L, Bushman, Frederic D, Parker, Kevin R, Qi, Yanyan, Satpathy, Ansuman T, Chang, Howard Y, Zhao, Yangbing, Lacey, Simon F, June, Carl H
Published in Science (American Association for the Advancement of Science) (28.02.2020)
Published in Science (American Association for the Advancement of Science) (28.02.2020)
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Journal Article
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Fraietta, Joseph A., Nobles, Christopher L., Sammons, Morgan A., Lundh, Stefan, Carty, Shannon A., Reich, Tyler J., Cogdill, Alexandria P., Morrissette, Jennifer J. D., DeNizio, Jamie E., Reddy, Shantan, Hwang, Young, Gohil, Mercy, Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Chen, Fang, Everett, John K., Alexander, Katherine A., Lin-Shiao, Enrique, Gee, Marvin H., Liu, Xiaojun, Young, Regina M., Ambrose, David, Wang, Yan, Xu, Jun, Jordan, Martha S., Marcucci, Katherine T., Levine, Bruce L., Garcia, K. Christopher, Zhao, Yangbing, Kalos, Michael, Porter, David L., Kohli, Rahul M., Lacey, Simon F., Berger, Shelley L., Bushman, Frederic D., June, Carl H., Melenhorst, J. Joseph
Published in Nature (London) (01.06.2018)
Published in Nature (London) (01.06.2018)
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Journal Article
NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma
Rapoport, Aaron P, Stadtmauer, Edward A, Binder-Scholl, Gwendolyn K, Goloubeva, Olga, Vogl, Dan T, Lacey, Simon F, Badros, Ashraf Z, Garfall, Alfred, Weiss, Brendan, Finklestein, Jeffrey, Kulikovskaya, Irina, Sinha, Sanjoy K, Kronsberg, Shari, Gupta, Minnal, Bond, Sarah, Melchiori, Luca, Brewer, Joanna E, Bennett, Alan D, Gerry, Andrew B, Pumphrey, Nicholas J, Williams, Daniel, Tayton- Martin, Helen K, Ribeiro, Lilliam, Holdich, Tom, Yanovich, Saul, Hardy, Nancy, Yared, Jean, Kerr, Naseem, Philip, Sunita, Westphal, Sandra, Siegel, Don L, Levine, Bruce L, Jakobsen, Bent K, Kalos, Michael, June, Carl H
Published in Nature medicine (01.08.2015)
Published in Nature medicine (01.08.2015)
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Journal Article
Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients
Marcucci, Katherine T., Jadlowsky, Julie K., Hwang, Wei-Ting, Suhoski-Davis, Megan, Gonzalez, Vanessa E., Kulikovskaya, Irina, Gupta, Minnal, Lacey, Simon F., Plesa, Gabriela, Chew, Anne, Melenhorst, J. Joseph, Levine, Bruce L., June, Carl H.
Published in Molecular therapy (03.01.2018)
Published in Molecular therapy (03.01.2018)
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Journal Article
Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells
Cameron, Brian J, Gerry, Andrew B, Dukes, Joseph, Harper, Jane V, Kannan, Vivekanandan, Bianchi, Frayne C, Grand, Francis, Brewer, Joanna E, Gupta, Minnal, Plesa, Gabriela, Bossi, Giovanna, Vuidepot, Annelise, Powlesland, Alex S, Legg, Alison, Adams, Katherine J, Bennett, Alan D, Pumphrey, Nicholas J, Williams, Daniel D, Binder-Scholl, Gwendolyn, Kulikovskaya, Irina, Levine, Bruce L, Riley, James L, Varela-Rohena, Angel, Stadtmauer, Edward A, Rapoport, Aaron P, Linette, Gerald P, June, Carl H, Hassan, Namir J, Kalos, Michael, Jakobsen, Bent K
Published in Science translational medicine (07.08.2013)
Published in Science translational medicine (07.08.2013)
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Journal Article
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia
Kong, Weimin, Dimitri, Alexander, Wang, Wenliang, Jung, In-Young, Ott, Christopher J, Fasolino, Maria, Wang, Yan, Kulikovskaya, Irina, Gupta, Minnal, Yoder, Todd, DeNizio, Jamie E, Everett, John K, Williams, Erik F, Xu, Jun, Scholler, John, Reich, Tyler J, Bhoj, Vijay G, Haines, Kathleen M, Maus, Marcela V, Melenhorst, J. Joseph, Young, Regina M, Jadlowsky, Julie K, Marcucci, Katherine T, Bradner, James E, Levine, Bruce L, Porter, David L, Bushman, Frederic D, Kohli, Rahul M, June, Carl H, Davis, Megan M, Lacey, Simon F, Vahedi, Golnaz, Fraietta, Joseph A
Published in The Journal of clinical investigation (15.08.2021)
Published in The Journal of clinical investigation (15.08.2021)
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Journal Article
Author Correction: Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
Melenhorst, J. Joseph, Chen, Gregory M., Wang, Meng, Porter, David L., Chen, Changya, Collins, McKensie A., Gao, Peng, Bandyopadhyay, Shovik, Sun, Hongxing, Zhao, Ziran, Lundh, Stefan, Pruteanu-Malinici, Iulian, Nobles, Christopher L., Maji, Sayantan, Frey, Noelle V., Gill, Saar I., Loren, Alison W., Tian, Lifeng, Kulikovskaya, Irina, Gupta, Minnal, Ambrose, David E., Davis, Megan M., Fraietta, Joseph A., Brogdon, Jennifer L., Young, Regina M., Chew, Anne, Levine, Bruce L., Siegel, Donald L., Alanio, Cécile, Wherry, E. John, Bushman, Frederic D., Lacey, Simon F., Tan, Kai, June, Carl H.
Published in Nature (London) (22.12.2022)
Published in Nature (London) (22.12.2022)
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Journal Article
Long-Term Remission of CLL Sustained By Pauciclonal Anti-CD19 Chimeric Antigen Receptor T (CTL019) Cell Clones
Melenhorst, J. Joseph, Porter, David L., Tian, Lifeng, Lacey, Simon F, Nobles, Christopher L, Fraietta, Joseph A, Frey, Noelle V., Kulikovskaya, Irina, Gupta, Minnal, Young, Regina M, Ambrose, David E, Siegel, Don L., Bushman, Frederic D, June, Carl H
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy
Garfall, Alfred L, Cohen, Adam D, Susanibar-Adaniya, Sandra P, Hwang, Wei-Ting, Vogl, Dan T, Waxman, Adam J, Lacey, Simon F, Gonzalez, Vanessa E, Fraietta, Joseph A, Gupta, Minnal, Kulikovskaya, Irina, Tian, Lifeng, Chen, Fang, Koterba, Natalka, Bartoszek, Robert L, Patchin, Margaret, Xu, Rong, Plesa, Gabriela, Siegel, Don L, Brennan, Andrea, Nelson, Anne Marie, Ferthio, Regina, Cosey, Angela, Shea, Kim-Marie, Leskowitz, Rachel, Four, Megan, Wilson, Wesley V, Miao, Fei, Lancaster, Eric, Carreno, Beatriz M, Linette, Gerald P, Hexner, Elizabeth O, Young, Regina M, Bu, Dexiu, Mansfield, Keith G, Brogdon, Jennifer L, June, Carl H, Milone, Michael C, Stadtmauer, Edward A
Published in Blood cancer discovery (01.03.2023)
Published in Blood cancer discovery (01.03.2023)
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Journal Article
Abstract LB-053: Next-generation sequencing of T-cell receptor-beta gene rearrangements reveals dramatic expansion of T-cell clonotypes after CART-EGFRvIII therapy for glioblastoma
O'Rourke, Donald M., Chen, Fang, Binder, Zev A., Kulikovskaya, Irina, Gupta, Minnal, Finklestein, Jeffrey, Ambrose, David E., Nasrallah, MacLean P., June, Carl H., Lacey, Simon F., Melenhorst, J. Joseph
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Safety and Efficacy of B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) with Cyclophosphamide Conditioning for Refractory Multiple Myeloma (MM)
Cohen, Adam D., Garfall, Alfred L., Stadtmauer, Edward A., Lacey, Simon F, Lancaster, Eric, Vogl, Dan T., Weiss, Brendan M, Ambrose, David E, Nelson, Anne Marie, Chen, Fang, Plesa, Gabriela, Kulikovskaya, Irina, Gonzalez, Vanessa, Gupta, Minnal, Young, Regina M, Dengel, Karen, O'keefe, Laura, Le, Samantha, Richardson, Celeste, Isaacs, Randi E., Melenhorst, J. Joseph, Levine, Bruce L, June, Carl H, Milone, Michael C.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Abstract 66: A multi-institution examination of concordance in spatial transcriptomics using the GeoMx Cancer Transcriptome Atlas
Hether, Tyler, Howes, Tim, Scoville, David, Glaser, Charlie, Li, Yanyun, Vanguri, Rami, Mohibullah, Neeman, Chang, Wan-Jung, Yoder, Todd, Gupta, Minnal, Ton, Kathy, Liang, Yan, Huang, Ying, Herbert, Zach, Reeves, Jason, Mittendorf, Elizabeth, Lacey, Simon, Hollmann, Travis, Warren, Sarah, LaVallee, Theresa
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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The effect of pembrolizumab in combination with CD19-targeted chimeric antigen receptor (CAR) T cells in relapsed acute lymphoblastic leukemia (ALL)
Maude, Shannon L., Hucks, George E, Seif, Alix Eden, Talekar, Mala Kiran, Teachey, David T., Baniewicz, Diane, Callahan, Colleen, Gonzalez, Vanessa, Nazimuddin, Farzana, Gupta, Minnal, Frey, Noelle V., Porter, David L., Levine, Bruce L, Melenhorst, Jan J., Lacey, Simon F., June, Carl H., Grupp, Stephan A.
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
Clinical Evidence That Deficiency of the Methylcytosine Dioxygenase TET2 Gene Promotes the Clonal Expansion and Therapeutic Efficacy of CD19-Directed T Cells
Fraietta, Joseph A, Nobles, Christopher L, Sammons, Morgan A, Carty, Shannon A., Lundh, Stefan M, Reich, Tyler, Cogdill, Alexandria P, Gohil, Mercy, Morrissette, Jennifer J.D., Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Wang, Yan, Liu, Xiaojun, Young, Regina M, Ambrose, David E, Jordan, Martha S, Marcucci, Katherine T, Levine, Bruce L, Zhao, Yangbing, Kalos, Michael, Porter, David L, Lacey, Simon F, Berger, Shelley L, Bushman, Frederic D, June, Carl H, Melenhorst, J. Joseph
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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