Discovery of Embelin as a Cell-Permeable, Small-Molecular Weight Inhibitor of XIAP through Structure-Based Computational Screening of a Traditional Herbal Medicine Three-Dimensional Structure Database
Nikolovska-Coleska, Zaneta, Xu, Liang, Hu, Zengjian, Tomita, York, Li, Peng, Roller, Peter P, Wang, Renxiao, Fang, Xueliang, Guo, Ribo, Zhang, Manchao, Lippman, Marc E, Yang, Dajun, Wang, Shaomeng
Published in Journal of medicinal chemistry (06.05.2004)
Published in Journal of medicinal chemistry (06.05.2004)
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Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling
Scholer-Dahirel, Alix, Schlabach, Michael R, Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K, Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R, Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E, McLaughlin, Margaret E
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (11.10.2011)
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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P, Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C, Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F, Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion
Published in ACS medicinal chemistry letters (10.06.2010)
Published in ACS medicinal chemistry letters (10.06.2010)
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1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity
Miller-Moslin, Karen, Peukert, Stefan, Jain, Rishi K, McEwan, Michael A, Karki, Rajesh, Llamas, Luis, Yusuff, Naeem, He, Feng, Li, Yanhong, Sun, Yingchuan, Dai, Miao, Perez, Lawrence, Michael, Walter, Sheng, Tao, Lei, Huangshu, Zhang, Rui, Williams, Juliet, Bourret, Aaron, Ramamurthy, Arun, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Maniara, Wieslawa, Amaral, Adam, Dorsch, Marion, Kelleher, Joseph F
Published in Journal of medicinal chemistry (09.07.2009)
Published in Journal of medicinal chemistry (09.07.2009)
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Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells
Zhang, Manchao, Liu, Hongpeng, Guo, Ribo, Ling, Yan, Wu, Xiaojin, Li, Bihua, Roller, Peter P., Wang, Shaomeng, Yang, Dajun
Published in Biochemical pharmacology (01.07.2003)
Published in Biochemical pharmacology (01.07.2003)
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Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening
Enyedy, Istvan J, Ling, Yan, Nacro, Kassoum, Tomita, York, Wu, Xihan, Cao, Yeyu, Guo, Ribo, Li, Bihua, Zhu, Xiaofeng, Huang, Ying, Long, Ya-Qiu, Roller, Peter P, Yang, Dajun, Wang, Shaomeng
Published in Journal of medicinal chemistry (06.12.2001)
Published in Journal of medicinal chemistry (06.12.2001)
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Targeting HSF1 sensitizes cancer cells to HSP90 inhibition
Chen, Yaoyu, Chen, Jinyun, Loo, Alice, Jaeger, Savina, Bagdasarian, Linda, Yu, Jianjun, Chung, Franklin, Korn, Joshua, Ruddy, David, Guo, Ribo, Mclaughlin, Margaret E., Feng, Fei, Zhu, Ping, Stegmeier, Frank, Pagliarini, Raymond, Porter, Dale, Zhou, Wenlai
Published in Oncotarget (30.06.2013)
Published in Oncotarget (30.06.2013)
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Macrocyclization in the Design of Grb2 SH2 Domain-Binding Ligands Exhibiting High Potency in Whole-Cell Systems
Wei, Chang-Qing, Gao, Yang, Lee, Kyeong, Guo, Ribo, Li, Bihua, Zhang, Manchao, Yang, Dajun, Burke, Terrence R
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
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Inhibition of Grb2 SH2 Domain Binding by Non-Phosphate-Containing Ligands. 2. 4-(2-Malonyl)phenylalanine as a Potent Phosphotyrosyl Mimetic
Gao, Yang, Luo, Juliet, Yao, Zhu-Jun, Guo, Ribo, Zou, Hong, Kelley, James, Voigt, Johannes H, Yang, Dajun, Burke, Terrence R
Published in Journal of medicinal chemistry (09.03.2000)
Published in Journal of medicinal chemistry (09.03.2000)
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Development of a Phosphatase-Stable Phosphotyrosyl Mimetic Suitably Protected for the Synthesis of High-Affinity Grb2 SH2 Domain-Binding Ligands
Wei, Chang-Qing, Li, Bihua, Guo, Ribo, Yang, Dajun, Burke, Jr, Terrence R
Published in Bioorganic & medicinal chemistry letters (07.10.2002)
Published in Bioorganic & medicinal chemistry letters (07.10.2002)
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Magnesium-chelatase from developing pea leaves: characterization of a soluble extract from chloroplasts and resolution into three required protein fractions
Guo, R. (Clemson University, Clemson, SC.), Luo, M, Weinstein, J.D
Published in Plant physiology (Bethesda) (01.02.1998)
Published in Plant physiology (Bethesda) (01.02.1998)
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LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors
Monaco, Kelli-Ann, Delach, Scott, Yuan, Jing, Mishina, Yuji, Fordjour, Paul, Labrot, Emma, McKay, Daniel, Guo, Ribo, Higgins, Stacy, Wang, Hui Qin, Liang, Jinsheng, Bui, Karen, Green, John, Aspesi, Peter, Ambrose, Jessi, Mapa, Felipa, Griner, Lesley, Jaskelioff, Mariela, Fuller, John, Crawford, Kenneth, Pardee, Gwynn, Widger, Stephania, Hammerman, Peter S, Engelman, Jeffrey A, Stuart, Darrin D, Cooke, Vesselina G, Caponigro, Giordano
Published in Clinical cancer research (01.04.2021)
Published in Clinical cancer research (01.04.2021)
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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
Buonamici, Silvia, Williams, Juliet, Morrissey, Michael, Wang, Anlai, Guo, Ribo, Vattay, Anthony, Hsiao, Kathy, Yuan, Jing, Green, John, Ospina, Beatriz, Yu, Qunyan, Ostrom, Lance, Fordjour, Paul, Anderson, Dustin L, Monahan, John E, Kelleher, Joseph F, Peukert, Stefan, Pan, Shifeng, Wu, Xu, Maira, Sauveur-Michel, García-Echeverría, Carlos, Briggs, Kimberly J, Watkins, D Neil, Yao, Yung-mae, Lengauer, Christoph, Warmuth, Markus, Sellers, William R, Dorsch, Marion
Published in Science translational medicine (29.09.2010)
Published in Science translational medicine (29.09.2010)
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A crucial requirement for Hedgehog signaling in small cell lung cancer
Park, Kwon-Sik, Martelotto, Luciano G, Peifer, Martin, Sos, Martin L, Karnezis, Anthony N, Mahjoub, Moe R, Bernard, Katie, Conklin, Jamie F, Szczepny, Anette, Yuan, Jing, Guo, Ribo, Ospina, Beatrice, Falzon, Jeanette, Bennett, Samara, Brown, Tracey J, Markovic, Ana, Devereux, Wendy L, Ocasio, Cory A, Chen, James K, Stearns, Tim, Thomas, Roman K, Dorsch, Marion, Buonamici, Silvia, Watkins, D Neil, Peacock, Craig D, Sage, Julien
Published in Nature medicine (01.11.2011)
Published in Nature medicine (01.11.2011)
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Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma
Visser, Michael, Papillon, Julien P. N., Luzzio, Michael, LaMarche, Matthew J., Fan, Jianmei, Michael, Walter, Wang, David, Zhang, Alan, Straub, Christopher, Mathieu, Simon, Kato, Mitsunori, Palermo, Mark, Chen, Christine, Ramsey, Timothy, Joud, Carol, Barrett, Rosemary, Vattay, Anthony, Guo, Ribo, Bric, Anka, Chung, Franklin, Liang, Guiqing, Romanowski, Michael J., Lam, Joni, Thohan, Sanjeev, Atassi, Faraj, Wylie, Andrew, Cooke, Vesselina G.
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors
Burke, Terrence R, Luo, Juliet, Yao, Zhu-Jun, Gao, Yang, Zhao, He, Milne, George W.A, Guo, Ribo, Voigt, Johannes H, Richter King, C, Yang, Dajun
Published in Bioorganic & medicinal chemistry letters (08.02.1999)
Published in Bioorganic & medicinal chemistry letters (08.02.1999)
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Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened
Peukert, Stefan, He, Feng, Dai, Miao, Zhang, Rui, Sun, Yingchuan, Miller-Moslin, Karen, McEwan, Michael, Lagu, Bharat, Wang, Kate, Yusuff, Naeem, Bourret, Aaron, Ramamurthy, Arun, Maniara, Wieslawa, Amaral, Adam, Vattay, Anthony, Wang, Anlai, Guo, Ribo, Yuan, Jing, Green, John, Williams, Juliet, Buonamici, Silvia, Kelleher III, Joseph F., Dorsch, Marion
Published in ChemMedChem (01.08.2013)
Published in ChemMedChem (01.08.2013)
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Abstract C149: The PKC inhibitor Sotrastaurin selectively inhibits the growth of GNAQ mutant uveal melanoma
Barrett, Rosemary, Guo, Ribo, Yuan, Jing, Cooke, Vesselina, Vattay, Anthony, Korn, Joshua, Liang, Guiqing, Li, Xin, Thiruvamoor, Ramu, Wylie, Andrew, Bric, Anka, Keen, Nicholas, Sellers, William
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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