Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
Murray, Brion W, Guo, Chuangxing, Piraino, Joseph, Westwick, John K, Zhang, Cathy, Lamerdin, Jane, Dagostino, Eleanor, Knighton, Daniel, Loi, Cho-Ming, Zager, Michael, Kraynov, Eugenia, Popoff, Ian, Christensen, James G, Martinez, Ricardo, Kephart, Susan E, Marakovits, Joseph, Karlicek, Shannon, Bergqvist, Simon, Smeal, Tod
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2010)
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Journal Article
Systematic Structure Modifications of Imidazo[1,2-a]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO)
Linton, Angelica, Kang, Ping, Ornelas, Martha, Kephart, Susan, Hu, Qiyue, Pairish, Mason, Jiang, Ying, Guo, Chuangxing
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Journal Article
Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket
Guo, Chuangxing, Hou, Xinjun, Dong, Liming, Marakovits, Joseph, Greasley, Samantha, Dagostino, Eleanor, Ferre, RoseAnn, Catherine Johnson, M., Humphries, Paul S., Li, Haitao, Paderes, Genevieve D., Piraino, Joseph, Kraynov, Eugenia, Murray, Brion W.
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
Published in Bioorganic & medicinal chemistry letters (01.09.2014)
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Journal Article
Structure-based design of novel human Pin1 inhibitors (I)
Guo, Chuangxing, Hou, Xinjun, Dong, Liming, Dagostino, Eleanor, Greasley, Samantha, Ferre, RoseAnn, Marakovits, Joseph, Johnson, M. Catherine, Matthews, David, Mroczkowski, Barbara, Parge, Hans, VanArsdale, Todd, Popoff, Ian, Piraino, Joseph, Margosiak, Stephen, Thomson, James, Los, Gerrit, Murray, Brion W.
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
Published in Bioorganic & medicinal chemistry letters (01.10.2009)
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Journal Article
Structure-based design of novel human Pin1 inhibitors (II)
Dong, Liming, Marakovits, Joseph, Hou, Xinjun, Guo, Chuangxing, Greasley, Samantha, Dagostino, Eleanor, Ferre, RoseAnn, Johnson, M. Catherine, Kraynov, Eugenia, Thomson, James, Pathak, Ved, Murray, Brion W.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists
Guo, Chuangxing, Pairish, Mason, Linton, Angelica, Kephart, Susan, Ornelas, Martha, Nagata, Asako, Burke, Benjamin, Dong, Liming, Engebretsen, Jon, Fanjul, Andrea N.
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Journal Article
Discovery of Pyrroloaminopyrazoles as Novel PAK Inhibitors
Guo, Chuangxing, McAlpine, Indrawan, Zhang, Junhu, Knighton, Daniel D, Kephart, Susan, Johnson, M. Catherine, Li, Haitao, Bouzida, Djamal, Yang, Anle, Dong, Liming, Marakovits, Joseph, Tikhe, Jayashree, Richardson, Paul, Guo, Lisa C, Kania, Robert, Edwards, Martin P, Kraynov, Eugenia, Christensen, James, Piraino, Joseph, Lee, Joseph, Dagostino, Eleanor, Del-Carmen, Christine, Deng, Ya-Li, Smeal, Tod, Murray, Brion W
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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Journal Article
Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists
Guo, Chuangxing, Linton, Angelica, Kephart, Susan, Ornelas, Martha, Pairish, Mason, Gonzalez, Javier, Greasley, Samantha, Nagata, Asako, Burke, Benjamin J, Edwards, Martin, Hosea, Natilie, Kang, Ping, Hu, Wenyue, Engebretsen, Jon, Briere, David, Shi, Manli, Gukasyan, Hovik, Richardson, Paul, Dack, Kevin, Underwood, Toby, Johnson, Patrick, Morell, Andrew, Felstead, Robert, Kuruma, Hidetoshi, Matsimoto, Hiroaki, Zoubeidi, Amina, Gleave, Martin, Los, Gerrit, Fanjul, Andrea N
Published in Journal of medicinal chemistry (10.11.2011)
Published in Journal of medicinal chemistry (10.11.2011)
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Journal Article
A novel method to enable SNAr reaction of aminopyrrolopyrazoles
CHUANGXING GUO, LIMING DONG, MARAKOVITS, Joseph, KEPHART, Susan
Published in Tetrahedron letters (06.04.2011)
Published in Tetrahedron letters (06.04.2011)
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Journal Article
An efficient synthesis of highly functionalized chiral lactams
Ornelas, Martha A., Gonzalez, Javier, Sach, Neal W., Richardson, Paul F., Bunker, Kevin D., Linton, Angelica, Kephart, Susan E., Pairish, Mason, Guo, Chuangxing
Published in Tetrahedron letters (14.09.2011)
Published in Tetrahedron letters (14.09.2011)
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Journal Article
Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer
Guo, Chuangxing, Kephart, Susan, Ornelas, Martha, Gonzalez, Javier, Linton, Angelica, Pairish, Mason, Nagata, Asako, Greasley, Samantha, Elleraas, Jeff, Hosea, Natilie, Engebretsen, Jon, Fanjul, Andrea N.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug–drug interaction
Palmer, Cynthia, Pairish, Mason, Kephart, Susan, Bouzida, Djamal, Cui, Jingrong, Deal, Judith, Dong, Liming, Gu, Danlin, Linton, Angelica, McAlpine, Indrawan, Yamazaki, Shinji, Smith, Evan, John-Baptiste, Annette, Bagrodia, Shubha, Kania, Robert, Guo, Chuangxing
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Design, Synthesis, and Biological Activity of Novel Polycyclic Aza-Amide FKBP12 Ligands
Hudack, Raymond A, Barta, Nancy S, Guo, Chuangxing, Deal, Judith, Dong, Liming, Fay, Lorraine K, Caprathe, Bradley, Chatterjee, Arindam, Vanderpool, Darin, Bigge, Christopher, Showalter, Richard, Bender, Steve, Augelli-Szafran, Corinne E, Lunney, Elizabeth, Hou, Xinjun
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Journal Article
Synthesis, Properties, Oxidation, and Electrochemistry of 1,2-Dichalcogenins
Block, Eric, Birringer, Marc, DeOrazio, Russell, Fabian, Jürgen, Glass, Richard S, Guo, Chuangxing, He, Chunhong, Lorance, Edward, Qian, Quangsheng, Schroeder, T. Benjamin, Shan, Zhixing, Thiruvazhi, Mohan, Wilson, George S, Zhang, Xing
Published in Journal of the American Chemical Society (31.05.2000)
Published in Journal of the American Chemical Society (31.05.2000)
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Journal Article
On the relationship of OSW-1 to the cephalostatins
Guo, Chuangxing, LaCour, Thomas G., Fuchs, P.L.
Published in Bioorganic & medicinal chemistry letters (08.02.1999)
Published in Bioorganic & medicinal chemistry letters (08.02.1999)
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Journal Article
A concise synthesis of AG5473/5507 utilizing N-acyliminium ion chemistry
Guo, Chuangxing, Reich, Siegfried, Showalter, Rich, Villafranca, Ernie, Dong, Liming
Published in Tetrahedron letters (08.07.2000)
Published in Tetrahedron letters (08.07.2000)
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Journal Article
Total Synthesis of Thiarubrine B [3-(3-Buten-1-ynyl)-6-(1,3-pentadiynyl)-1,2-dithiin], the Antibiotic Principle of Giant Ragweed (Ambrosia trifida)
Block, Eric, Guo, Chuangxing, Thiruvazhi, Mohan, Toscano, Paul J
Published in Journal of the American Chemical Society (01.10.1994)
Published in Journal of the American Chemical Society (01.10.1994)
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Journal Article
On topography and functionality in the B-D rings of cephalostatin cytotoxins
LaCour, Thomas G., Guo, Chuangxing, Ma, Sunghoon, Jeong, Jae Uk, Boyd, Michael R., Matsunaga, Shikegi, Fusetani, Nobuhiro, Fuchs, P.L.
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
Published in Bioorganic & medicinal chemistry letters (06.09.1999)
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