Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties
Over, Björn, McCarren, Patrick, Artursson, Per, Foley, Michael, Giordanetto, Fabrizio, Grönberg, Gunnar, Hilgendorf, Constanze, Lee, Maurice D, Matsson, Pär, Muncipinto, Giovanni, Pellisson, Mélanie, Perry, Matthew W. D, Svensson, Richard, Duvall, Jeremy R, Kihlberg, Jan
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Impact of Excited-State Antiaromaticity Relief in a Fundamental Benzene Photoreaction Leading to Substituted Bicyclo[3.1.0]hexenes
Slanina, Tomáš, Ayub, Rabia, Toldo, Josene, Sundell, Johan, Rabten, Wangchuk, Nicaso, Marco, Alabugin, Igor, Fdez. Galván, Ignacio, Gupta, Arvind K, Lindh, Roland, Orthaber, Andreas, Lewis, Richard J, Grönberg, Gunnar, Bergman, Joakim, Ottosson, Henrik
Published in Journal of the American Chemical Society (24.06.2020)
Published in Journal of the American Chemical Society (24.06.2020)
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Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles
Tesei, Giulio, Hsiao, Ya-Wen, Dabkowska, Aleksandra, Grönberg, Gunnar, Yanez Arteta, Marianna, Ulkoski, David, Bray, David J, Trulsson, Martin, Ulander, Johan, Lund, Mikael, Lindfors, Lennart
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (09.01.2024)
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Journal Article
Synthesis of 1 lambda(6),2,4,6-Thiatriazine-1,3,5-Trione Derivatives
Chen, Yantao, Soderlund, Johan, Gronberg, Gunnar, Pettersen, Anna, Aurell, Carl-Johan
Published in European journal of organic chemistry (07.08.2019)
Published in European journal of organic chemistry (07.08.2019)
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Metabolism of Strained Rings: Glutathione S -transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation
Li, Xue-Qing, Grönberg, Gunnar, Bangur, Eva-Henriette, Hayes, Martin A, Castagnoli, Jr, Neal, Weidolf, Lars
Published in Drug metabolism and disposition (01.11.2019)
Published in Drug metabolism and disposition (01.11.2019)
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Journal Article
Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability
Andersson, Vincent, Bergström, Fredrik, Brånalt, Jonas, Grönberg, Gunnar, Gustafsson, David, Karlsson, Staffan, Polla, Magnus, Bergman, Joakim, Kihlberg, Jan
Published in Journal of medicinal chemistry (28.07.2016)
Published in Journal of medicinal chemistry (28.07.2016)
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Synthesis of Stable Isotope, Tritiated, and Carbon‐14 Labeled Balcinrenone
Bergare, Jonas, Bailey, Christopher, Sörensen, Henrik, Grönberg, Gunnar, Broberg, Karl, Berglund, Monica, Grecu, Tudor, Sanchez, Carolina, Emtenäs, Hans, Bragg, Ryan A., Elmore, Charles S.
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2024)
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2024)
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Characterization and demonstration of drug compound ring-chain tautomer formation and its impacts on quality control
Ottosson, Jenny E., Gränfors, Malin, van Pelt, Sally, Langborg Weinmann, Annika, Nilsson Lill, Sten O., Hulthe, Gustaf, Grönberg, Gunnar
Published in Journal of pharmaceutical and biomedical analysis (10.05.2021)
Published in Journal of pharmaceutical and biomedical analysis (10.05.2021)
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Journal Article
CYP3A Specifically Catalyzes 1β-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity
Hayes, Martin A, Li, Xue-Qing, Grönberg, Gunnar, Diczfalusy, Ulf, Andersson, Tommy B
Published in Drug metabolism and disposition (01.09.2016)
Published in Drug metabolism and disposition (01.09.2016)
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Journal Article
A P450 fusion library of heme domains from Rhodococcus jostii RHA1 and its evaluation for the biotransformation of drug molecules
Kulig, Justyna K., Spandolf, Claudia, Hyde, Ralph, Ruzzini, Antonio C., Eltis, Lindsay D., Grönberg, Gunnar, Hayes, Martin A., Grogan, Gideon
Published in Bioorganic & medicinal chemistry (01.09.2015)
Published in Bioorganic & medicinal chemistry (01.09.2015)
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Journal Article
Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts
Paunovic, Amalia I, Drowley, Lauren, Nordqvist, Anneli, Ericson, Elke, Mouchet, Elizabeth, Jonebring, Anna, Grönberg, Gunnar, Kvist, Alexander J, Engkvist, Ola, Brown, Martin R, Gedda, Karin, Goumans, Marie-José, Wang, Qing-Dong, Plowright, Alleyn T
Published in ACS chemical biology (20.01.2017)
Published in ACS chemical biology (20.01.2017)
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4,4,16‐Trifluoropalmitate: Design, Synthesis, Tritiation, Radiofluorination and Preclinical PET Imaging Studies on Myocardial Fatty Acid Oxidation
Colombano, Alessandro, Dall'Angelo, Sergio, Kingston, Lee, Grönberg, Gunnar, Correia, Claudia, Passannante, Rossana, Baz, Zuriñe, Morcillo, Miguel Ángel, Elmore, Charles S., Llop, Jordi, Zanda, Matteo
Published in ChemMedChem (03.12.2020)
Published in ChemMedChem (03.12.2020)
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Journal Article
Electrochemical Generation of Electrophilic Drug Metabolites: Characterization of Amodiaquine Quinoneimine and Cysteinyl Conjugates by MS, IR, and NMR
Jurva, Ulrik, Holmén, Anders, Grönberg, Gunnar, Masimirembwa, Collen, Weidolf, Lars
Published in Chemical research in toxicology (01.04.2008)
Published in Chemical research in toxicology (01.04.2008)
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Journal Article
Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes
Madsen, Kim G, Grönberg, Gunnar, Skonberg, Christian, Jurva, Ulrik, Hansen, Steen H, Olsen, Jørgen
Published in Chemical research in toxicology (01.10.2008)
Published in Chemical research in toxicology (01.10.2008)
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Journal Article
Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR
JOHANSSON, Tove, JURVA, Ulrik, GRÖNBERG, Gunnar, WEIDOLF, Lars, MASIMIREMBWA, Collen
Published in Drug metabolism and disposition (01.03.2009)
Published in Drug metabolism and disposition (01.03.2009)
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Journal Article
Synthesis of 2 C‐14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole
Kingston, Lee, Bergare, Jonas, Lönn, Hans, Ericsson, Cecilia, Grönberg, Gunnar, Chen, Song, Elmore, Charles S.
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2017)
Published in Journal of labelled compounds & radiopharmaceuticals (30.05.2017)
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Journal Article
Synthesis of [3H] and [2H6]AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP)
Lindelöf, Åsa, Ericsson, Cecilia, Simonsson, Roger, Nilsson, Göran, Grönberg, Gunnar, Elmore, Charles S.
Published in Journal of labelled compounds & radiopharmaceuticals (01.07.2016)
Published in Journal of labelled compounds & radiopharmaceuticals (01.07.2016)
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Journal Article
Synthesis of 1λ 6 ,2,4,6‐Thiatriazine‐1,3,5‐Trione Derivatives
Chen, Yantao, Söderlund, Johan, Grönberg, Gunnar, Pettersen, Anna, Aurell, Carl‐Johan
Published in European journal of organic chemistry (07.08.2019)
Published in European journal of organic chemistry (07.08.2019)
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Journal Article