HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia
Das, Nabanita, Dewan, Varun, Grace, Peter M., Gunn, Robin J., Tamura, Ryo, Tzarum, Netanel, Watkins, Linda R., Wilson, Ian A., Yin, Hang
Published in Cell reports (Cambridge) (18.10.2016)
Published in Cell reports (Cambridge) (18.10.2016)
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Journal Article
Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers
Smith, Christopher R, Aranda, Ruth, Bobinski, Thomas P, Briere, David M, Burns, Aaron C, Christensen, James G, Clarine, Jeffery, Engstrom, Lars D, Gunn, Robin J, Ivetac, Anthony, Jean-Baptiste, Ronald, Ketcham, John M, Kobayashi, Masakazu, Kuehler, Jon, Kulyk, Svitlana, Lawson, J. David, Moya, Krystal, Olson, Peter, Rahbaek, Lisa, Thomas, Nicole C, Wang, Xiaolun, Waters, Laura M, Marx, Matthew A
Published in Journal of medicinal chemistry (10.02.2022)
Published in Journal of medicinal chemistry (10.02.2022)
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Journal Article
Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction
Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.
Published in Journal of medicinal chemistry (28.07.2022)
Published in Journal of medicinal chemistry (28.07.2022)
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Journal Article
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X‑Ray Cocrystallography
Smith, Christopher R., Chen, Dan, Christensen, James G., Coulombe, René, Féthière, James, Gunn, Robin J., Hollander, Johan, Jones, Benjamin, Ketcham, John M., Khare, Shilpi, Kuehler, Jon, Lawson, J. David, Marx, Matthew A., Olson, Peter, Pearson, Kelly E., Ren, Cynthia, Tsagris, Denise, Ulaganathan, Thirumalaiselvi, Van’t Veer, Inge, Wang, Xiaolun, Ivetac, Anthony
Published in Journal of medicinal chemistry (11.01.2024)
Published in Journal of medicinal chemistry (11.01.2024)
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Journal Article
Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors
Smith, Christopher R., Aranda, Ruth, Christensen, James G., Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Ketcham, John M., Kuehler, Jon, David Lawson, J., Marx, Matthew A., Olson, Peter, Thomas, Nicole C., Wang, Xiaolun, Waters, Laura M., Kulyk, Svitlana
Published in Bioorganic & medicinal chemistry (01.10.2022)
Published in Bioorganic & medicinal chemistry (01.10.2022)
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Journal Article
Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein
Ketcham, John M., Harwood, Stephen J., Aranda, Ruth, Aloiau, Athenea N., Bobek, Briana M., Briere, David M., Burns, Aaron C., Caddell Haatveit, Kersti, Calinisan, Andrew, Clarine, Jeffery, Elliott, Adam, Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Jones, Benjamin, Kuehler, Jon, Lawson, J. David, Nguyen, Natalie, Parker, Cody, Pearson, Kelly E., Rahbaek, Lisa, Saechao, Barbara, Wang, Xiaolun, Waters, Anna, Waters, Laura, Watkins, Ashlee H., Olson, Peter, Smith, Christopher R., Christensen, James G., Marx, Matthew A.
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Journal Article
Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor
Hallin, Jill, Bowcut, Vickie, Calinisan, Andrew, Briere, David M., Hargis, Lauren, Engstrom, Lars D., Laguer, Jade, Medwid, James, Vanderpool, Darin, Lifset, Ella, Trinh, David, Hoffman, Natalie, Wang, Xiaolun, David Lawson, J., Gunn, Robin J., Smith, Christopher R., Thomas, Nicole C., Martinson, Matthew, Bergstrom, Alex, Sullivan, Francis, Bouhana, Karyn, Winski, Shannon, He, Leo, Fernandez-Banet, Julio, Pavlicek, Adam, Haling, Jacob R., Rahbaek, Lisa, Marx, Matthew A., Olson, Peter, Christensen, James G.
Published in Nature medicine (01.10.2022)
Published in Nature medicine (01.10.2022)
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Journal Article
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor
Wang, Xiaolun, Allen, Shelley, Blake, James F, Bowcut, Vickie, Briere, David M, Calinisan, Andrew, Dahlke, Joshua R, Fell, Jay B, Fischer, John P, Gunn, Robin J, Hallin, Jill, Laguer, Jade, Lawson, J David, Medwid, James, Newhouse, Brad, Nguyen, Phong, O'Leary, Jacob M, Olson, Peter, Pajk, Spencer, Rahbaek, Lisa, Rodriguez, Mareli, Smith, Christopher R, Tang, Tony P, Thomas, Nicole C, Vanderpool, Darin, Vigers, Guy P, Christensen, James G, Marx, Matthew A
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Journal Article
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor
Wang, Xiaolun, Allen, Shelley, Blake, James F, Bowcut, Vickie, Briere, David M, Calinisan, Andrew, Dahlke, Joshua R, Fell, Jay B, Fischer, John P, Gunn, Robin J, Hallin, Jill, Laguer, Jade, Lawson, J. David, Medwid, James, Newhouse, Brad, Nguyen, Phong, O’Leary, Jacob M, Olson, Peter, Pajk, Spencer, Rahbaek, Lisa, Rodriguez, Mareli, Smith, Christopher R, Tang, Tony P, Thomas, Nicole C, Vanderpool, Darin, Vigers, Guy P, Christensen, James G, Marx, Matthew A
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Journal Article
Flagellin as Carrier and Adjuvant in Cocaine Vaccine Development
Lockner, Jonathan W, Eubanks, Lisa M, Choi, Jennifer L, Lively, Jenny M, Schlosburg, Joel E, Collins, Karen C, Globisch, Daniel, Rosenfeld-Gunn, Robin J, Wilson, Ian A, Janda, Kim D
Published in Molecular pharmaceutics (02.02.2015)
Published in Molecular pharmaceutics (02.02.2015)
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Journal Article
Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits
Smith, Christopher R, Kulyk, Svitlana, Ahmad, Misbha Ud Din, Arkhipova, Valentina, Christensen, James G, Gunn, Robin J, Ivetac, Anthony, Ketcham, John M, Kuehler, Jon, Lawson, J. David, Thomas, Nicole C, Wang, Xiaolun, Marx, Matthew A
Published in MedChemComm (14.12.2022)
Published in MedChemComm (14.12.2022)
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Journal Article
Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors
Smith, Christopher R., Aranda, Ruth, Christensen, James G., Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Ketcham, John M., Kuehler, Jon, David Lawson, J., Marx, Matthew A., Olson, Peter, Thomas, Nicole C., Wang, Xiaolun, Waters, Laura M., Kulyk, Svitlana
Published in Bioorganic & medicinal chemistry (01.10.2022)
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Published in Bioorganic & medicinal chemistry (01.10.2022)
Journal Article
Abstract ND04: Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer
Marx, Matthew A., Burns, Aaron C., Arora, Nidhi, Bobinski, Thomas P., Briere, David M., Calinisan, Andrew, Gunn, Robin J., Ketcham, John M., Lawson, David, Lee, Matthew, Olson, Peter, Smith, Christopher R., Sudhakar, Niranjan, Christensen, James G., Chen, Chelsea X., Yuen, Natalie, Ulicna, Livia, Duong, Frank, Colas, Christophe, Ramnath, Anjana, Xu, Ron, Maneval, Edna Chow, Multani, Pratik S., Patel, Rupal, Kumar, Archana, Daemen, Anneleen, Romero, Anthony, Junttila, Melissa R., Friedman, Lori S.
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Journal Article
Abstract ND02: MRTX0902: A SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers
Ketcham, John M., Khare, Shilpi, Sudhakar, Niranjan, Briere, David M., Yan, Larry, Laguer, Jade, Vegar, Laura, Vanderpool, Darin, Hallin, Jill, Hargis, Lauren, Bowcut, Vickie, Lawson, David, Gunn, Robin J., Ivetac, Anthony, Thomas, Nicole C., Saechao, Barbara, Nguyen, Natalie, Clarine, Jeffrey, Rahbaek, Lisa, Smith, Christopher R., Burns, Aaron C., Marx, Matthew A., Christensen, James G., Olson, Peter, Haling, Jacob R.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract LB505: Design and discovery of MRTX0902, a potent, selective, and orally bioavailable SOS1 inhibitor
Ketcham, John M., Briere, David M., Burns, Aaron C., Christensen, James G., Gunn, Robin J., Haling, Jacob, Ivetac, Anthony, Khare, Shilpi, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, John D., Moya, Krystal, Nguyen, Natalie, Olson, Peter, Rahbaek, Lisa, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vanderpool, Darin, Wang, Xiaolun, Marx, Matthew A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Anti-tumor efficacy of a potent and selective non-covalent KRAS G12D inhibitor
Hallin, Jill, Bowcut, Vickie, Calinisan, Andrew, Briere, David M, Hargis, Lauren, Engstrom, Lars D, Laguer, Jade, Medwid, James, Vanderpool, Darin, Lifset, Ella, Trinh, David, Hoffman, Natalie, Wang, Xiaolun, David Lawson, J, Gunn, Robin J, Smith, Christopher R, Thomas, Nicole C, Martinson, Matthew, Bergstrom, Alex, Sullivan, Francis, Bouhana, Karyn, Winski, Shannon, He, Leo, Fernandez-Banet, Julio, Pavlicek, Adam, Haling, Jacob R, Rahbaek, Lisa, Marx, Matthew A, Olson, Peter, Christensen, James G
Published in Nature medicine (01.10.2022)
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Published in Nature medicine (01.10.2022)
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