Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance
Ridinger, Johannes, Koeneke, Emily, Kolbinger, Fiona R., Koerholz, Katharina, Mahboobi, Siavosh, Hellweg, Lars, Gunkel, Nikolas, Miller, Aubry K., Peterziel, Heike, Schmezer, Peter, Hamacher-Brady, Anne, Witt, Olaf, Oehme, Ina
Published in Scientific reports (03.07.2018)
Published in Scientific reports (03.07.2018)
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Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease
Fritzsching, Benedikt, Zhou-Suckow, Zhe, Trojanek, Joanna B, Schubert, Susanne C, Schatterny, Jolanthe, Hirtz, Stephanie, Agrawal, Raman, Muley, Thomas, Kahn, Nicolas, Sticht, Carsten, Gunkel, Nikolas, Welte, Tobias, Randell, Scott H, Länger, Florian, Schnabel, Philipp, Herth, Felix J F, Mall, Marcus A
Published in American journal of respiratory and critical care medicine (15.04.2015)
Published in American journal of respiratory and critical care medicine (15.04.2015)
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Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs
Samarin, Jana, Fabrowski, Piotr, Kurilov, Roman, Nuskova, Hana, Hummel-Eisenbeiss, Johanna, Pink, Hannelore, Li, Nan, Weru, Vivienn, Alborzinia, Hamed, Yildiz, Umut, Grob, Laura, Taubert, Minerva, Czech, Marie, Morgen, Michael, Brandstädter, Christina, Becker, Katja, Mao, Lianghao, Jayavelu, Ashok Kumar, Goncalves, Angela, Uhrig, Ulrike, Seiler, Jeanette, Lyu, Yanhong, Diederichs, Sven, Klingmüller, Ursula, Muckenthaler, Martina, Kopp-Schneider, Annette, Teleman, Aurelio, Miller, Aubry K., Gunkel, Nikolas
Published in Redox biology (01.06.2023)
Published in Redox biology (01.06.2023)
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Journal Article
Real‐world evidence for preventive effects of statins on cancer incidence: A trans‐Atlantic analysis
Gohlke, Bjoern‐O, Zincke, Fabian, Eckert, Andreas, Kobelt, Dennis, Preissner, Saskia, Liebeskind, Juliane Maria, Gunkel, Nikolas, Putzker, Kerstin, Lewis, Joe, Preissner, Sally, Kortüm, Benedikt, Walther, Wolfgang, Mura, Cameron, Bourne, Philip E., Stein, Ulrike, Preissner, Robert
Published in Clinical and translational medicine (01.02.2022)
Published in Clinical and translational medicine (01.02.2022)
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Journal Article
Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated
Géraldy, Magalie, Morgen, Michael, Sehr, Peter, Steimbach, Raphael R, Moi, Davide, Ridinger, Johannes, Oehme, Ina, Witt, Olaf, Malz, Mona, Nogueira, Mauro S, Koch, Oliver, Gunkel, Nikolas, Miller, Aubry K
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Journal Article
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout br
Steimbach, Raphael R., Herbst-Gervasoni, Corey J., Lechner, Severin, Stewart, Tracy Murray, Klinke, Glynis, Ridinger, Johannes, Geraldy, Magalie N. E., Tihanyi, Gergely, Foley, Jackson R., Uhrig, Ulrike, Kuster, Bernhard, Poschet, Gernot, Casero, Robert A., Medard, Guillaume, Oehme, Ina, Christianson, David W., Gunkel, Nikolas, Miller, Aubry K.
Published in Journal of the American Chemical Society (19.10.2022)
Published in Journal of the American Chemical Society (19.10.2022)
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Journal Article
Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction
Muckenthaler, Lena, Marques, Oriana, Colucci, Silvia, Kunz, Joachim, Fabrowski, Piotr, Bast, Thomas, Altamura, Sandro, Höchsmann, Britta, Schrezenmeier, Hubert, Langlotz, Monika, Richter-Pechanska, Paulina, Rausch, Tobias, Hofmeister-Mielke, Nicole, Gunkel, Nikolas, Hentze, Matthias W., Kulozik, Andreas E., Muckenthaler, Martina U.
Published in Blood (03.03.2022)
Published in Blood (03.03.2022)
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Journal Article
The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines
Kolbinger, Fiona R., Koeneke, Emily, Ridinger, Johannes, Heimburg, Tino, Müller, Michael, Bayer, Theresa, Sippl, Wolfgang, Jung, Manfred, Gunkel, Nikolas, Miller, Aubry K., Westermann, Frank, Witt, Olaf, Oehme, Ina
Published in Archives of toxicology (01.08.2018)
Published in Archives of toxicology (01.08.2018)
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Journal Article
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement
Herp, Daniel, Ridinger, Johannes, Robaa, Dina, Shinsky, Stephen A., Schmidtkunz, Karin, Yesiloglu, Talha Z., Bayer, Theresa, Steimbach, Raphael R., Herbst‐Gervasoni, Corey J., Merz, Annika, Romier, Christophe, Sehr, Peter, Gunkel, Nikolas, Miller, Aubry K., Christianson, David W., Oehme, Ina, Sippl, Wolfgang, Jung, Manfred
Published in Chembiochem : a European journal of chemical biology (19.07.2022)
Published in Chembiochem : a European journal of chemical biology (19.07.2022)
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Journal Article
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout
Steimbach, Raphael R., Herbst-Gervasoni, Corey J., Lechner, Severin, Stewart, Tracy Murray, Klinke, Glynis, Ridinger, Johannes, Géraldy, Magalie N. E., Tihanyi, Gergely, Foley, Jackson R., Uhrig, Ulrike, Kuster, Bernhard, Poschet, Gernot, Casero, Robert A., Médard, Guillaume, Oehme, Ina, Christianson, David W., Gunkel, Nikolas, Miller, Aubry K.
Published in Journal of the American Chemical Society (19.10.2022)
Published in Journal of the American Chemical Society (19.10.2022)
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Journal Article
Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity
De Vita, Elena, Schüler, Peter, Lovell, Scott, Lohbeck, Jasmin, Kullmann, Sven, Rabinovich, Eitan, Sananes, Amiram, Heßling, Bernd, Hamon, Veronique, Papo, Niv, Hess, Jochen, Tate, Edward W, Gunkel, Nikolas, Miller, Aubry K
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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Journal Article
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors
Morgen, Michael, Steimbach, Raphael R., Géraldy, Magalie, Hellweg, Lars, Sehr, Peter, Ridinger, Johannes, Witt, Olaf, Oehme, Ina, Herbst‐Gervasoni, Corey J., Osko, Jeremy D., Porter, Nicholas J., Christianson, David W., Gunkel, Nikolas, Miller, Aubry K.
Published in ChemMedChem (03.07.2020)
Published in ChemMedChem (03.07.2020)
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Journal Article
Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity
Morgen, Michael, Jöst, Christian, Malz, Mona, Janowski, Robert, Niessing, Dierk, Klein, Christian D, Gunkel, Nikolas, Miller, Aubry K
Published in ACS chemical biology (15.04.2016)
Published in ACS chemical biology (15.04.2016)
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Journal Article
Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6
De Vita, Elena, Smits, Niels, Hurk, Helma, Beck, Elizabeth M., Hewitt, Joanne, Baillie, Gemma, Russell, Emily, Pannifer, Andrew, Hamon, Véronique, Morrison, Angus, McElroy, Stuart P., Jones, Philip, Ignatenko, Natalia A., Gunkel, Nikolas, Miller, Aubry K.
Published in ChemMedChem (07.01.2020)
Published in ChemMedChem (07.01.2020)
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Journal Article
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma
Seidensaal, Katharina, Nollert, Andre, Feige, Agnes Hiou, Muller, Marie, Fleming, Thomas, Gunkel, Nikolas, Zaoui, Karim, Grabe, Niels, Weichert, Wilko, Weber, Klaus-Josef, Plinkert, Peter, Simon, Christian, Hess, Jochen
Published in Molecular cancer (03.12.2015)
Published in Molecular cancer (03.12.2015)
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Journal Article
The response of Mannheimia haemolytica to iron limitation: Implications for the acquisition of iron in the bovine lung
Roehrig, Susanna C., Tran, Hon Q., Spehr, Volker, Gunkel, Nikolas, Selzer, Paul M., Ullrich, Heinz J.
Published in Veterinary microbiology (15.04.2007)
Published in Veterinary microbiology (15.04.2007)
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Journal Article
Microarray analysis of Haemophilus parasuis gene expression under in vitro growth conditions mimicking the in vivo environment
Melnikow, Elena, Dornan, Saffron, Sargent, Carole, Duszenko, Michael, Evans, Gary, Gunkel, Nikolas, Selzer, Paul M., Ullrich, Heinz J.
Published in Veterinary microbiology (31.10.2005)
Published in Veterinary microbiology (31.10.2005)
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