A Polymer-Based Antibody-Vinca Drug Conjugate Platform: Characterization and Preclinical Efficacy
Yurkovetskiy, Alexander V, Yin, Mao, Bodyak, Natalya, Stevenson, Cheri A, Thomas, Joshua D, Hammond, Charles E, Qin, LiuLiang, Zhu, Bangmin, Gumerov, Dmitry R, Ter-Ovanesyan, Elena, Uttard, Alex, Lowinger, Timothy B
Published in Cancer research (Chicago, Ill.) (15.08.2015)
Published in Cancer research (Chicago, Ill.) (15.08.2015)
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Journal Article
Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry
Han, Jun, Danell, Ryan M, Patel, Jayanti R, Gumerov, Dmitry R, Scarlett, Cameron O, Speir, J. Paul, Parker, Carol E, Rusyn, Ivan, Zeisel, Steven, Borchers, Christoph H
Published in Metabolomics (01.06.2008)
Published in Metabolomics (01.06.2008)
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Journal Article
Dolaflexin: A Novel Antibody-Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect
Yurkovetskiy, Aleksandr V, Bodyak, Natalya D, Yin, Mao, Thomas, Joshua D, Clardy, Susan M, Conlon, Patrick R, Stevenson, Cheri A, Uttard, Alex, Qin, LiuLiang, Gumerov, Dmitry R, Ter-Ovanesyan, Elena, Bu, Charlie, Johnson, Alex J, Gurijala, Venu R, McGillicuddy, Dennis, DeVit, Michael J, Poling, Laura L, Protopopova, Marina, Xu, Ling, Zhang, Qingxiu, Park, Peter U, Bergstrom, Donald A, Lowinger, Timothy B
Published in Molecular cancer therapeutics (01.05.2021)
Published in Molecular cancer therapeutics (01.05.2021)
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Journal Article
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b
Bodyak, Natalya D, Mosher, Rebecca, Yurkovetskiy, Aleksandr V, Yin, Mao, Bu, Charlie, Conlon, Patrick R, Demady, Damon R, DeVit, Michael J, Gumerov, Dmitry R, Gurijala, Venu R, Lee, Winnie, McGillicuddy, Dennis, Park, Peter U, Poling, Laura L, Protopova, Marina, Qin, LiuLiang, Stevenson, Cheri A, Ter-Ovanesyan, Elena, Uttard, Alex, Xiao, Dongmei, Xu, Jian, Xu, Ling, Bergstrom, Donald A, Lowinger, Timothy B
Published in Molecular cancer therapeutics (01.05.2021)
Published in Molecular cancer therapeutics (01.05.2021)
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Discovery of novel polyamide-pyrrolobenzodiazepine hybrids for antibody-drug conjugates
Thomas, Joshua D., Yurkovetskiy, Aleksandr V., Yin, Mao, Bodyak, Natalya D., Gumerov, Dmitry R., Tang, Shuyi, Kelleher, Eoin, Jones, Brian D., Protopopova, Marina, Qin, LiuLiang, Uttard, Alex, Demady, Damon R., Lowinger, Timothy B.
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
Published in Bioorganic & medicinal chemistry letters (15.09.2022)
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Transferrin as a model system for method development to study structure, dynamics and interactions of metalloproteins using mass spectrometry
Kaltashov, Igor A., Bobst, Cedric E., Zhang, Mingxuan, Leverence, Rachael, Gumerov, Dmitry R.
Published in Biochimica et biophysica acta (01.03.2012)
Published in Biochimica et biophysica acta (01.03.2012)
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Abstract 596: Optimization of lead antibody selection for XMT-1522, a novel, highly potent HER2-targeted antibody-drug conjugate (ADC)
Bodyak, Natasha, Yurkovetskiy, Alex, Gumerov, Dmitry R., Xiao, Dongmei, Thomas, Joshua D. Thomas D., Poling, Laura L., Qin, LiuLiang, Yin, Mao, DeVit, Michael J., Park, Peter U., Lee, Winnie, Prinz, Bianka, Bergstrom, Donald A., Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
PEPTIDE-CONTAINING LINKERS FOR ANTIBODY-DRUG CONJUGATES
STEVENSON CHERI A, YIN MAO, BODYAK NATALYA D, YURKOVETSKIY ALEKSANDR V, KOZYTSKA MARIYA, DU BINGFAN, LOWINGER TIMOTHY B, GUMEROV DMITRY R
Year of Publication 13.02.2024
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Year of Publication 13.02.2024
Patent
Differential Effect of a His Tag at the N- and C-Termini: Functional Studies with Recombinant Human Serum Transferrin
Mason, Anne B, He, Qing-Yu, Halbrooks, Peter J, Everse, Stephen J, Gumerov, Dmitry R, Kaltashov, Igor A, Smith, Valerie C, Hewitt, Jeff, MacGillivray, Ross T. A
Published in Biochemistry (Easton) (30.07.2002)
Published in Biochemistry (Easton) (30.07.2002)
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항체-약물 접합체를 위한 펩타이드 함유 링커
STEVENSON CHERI A, YIN MAO, BODYAK NATALYA D, YURKOVETSKIY ALEKSANDR V, KOZYTSKA MARIYA, DU BINGFAN, LOWINGER TIMOTHY B, GUMEROV DMITRY R
Year of Publication 24.07.2019
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Year of Publication 24.07.2019
Patent
Protein-Polymer-Drug Conjugates
YURKOVETSKIY ALEKSANDR, STEVENSON CHERI A, YIN MAO, BODYAK NATALYA D, CONLON PATRICK R, LOWINGER TIMOTHY B, THOMAS JOSHUA D, HAMMOND CHARLES E, GUMEROV DMITRY R
Year of Publication 30.04.2019
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Year of Publication 30.04.2019
Patent
PROTEIN-POLYMER-DRUG CONJUGATES
YURKOVETSKIY ALEKSANDR, STEVENSON CHERI A, YIN MAO, BODYAK NATALYA D, CONLON PATRICK R, LOWINGER TIMOTHY B, THOMAS JOSHUA D, HAMMOND CHARLES E, GUMEROV DMITRY R
Year of Publication 29.04.2014
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Year of Publication 29.04.2014
Patent
Abstract 641: Trastuzumab-dolaflexin, a highly potent Fleximer-based antibody-drug conjugate, demonstrates a favorable therapeutic index in exploratory toxicology studies in multiple species
Bodyak, Natalya, Yurkovetskiy, Alex, Park, Peter U., Gumerov, Dmitry R., DeVit, Michael, Yin, Mao, Thomas, Joshua D., Qin, LiuLiang, Lowinger, Timothy B., Bergstrom, Donald A.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 2645: Advantages of polyacetal polymer-based ADCs: Application to low expression targets
Yurkovetskiy, Alex, Bodyak, Natalya, Yin, Mao, Thomas, Joshua D., Conlon, Patrick, Stevenson, Cheri A., Uttard, Alex, Qin, LiuLiang, Gumerov, Dmitry R., Ter-Ovaneysan, Elena, Gurijala, Venu R., McGillicuddy, Dennis, Glynn, Roberta E., DeVit, Michael, Poling, Laura L., Park, Peter U., Lowinger, Timothy B.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Peptide-containing linkers for antibody-drug conjugates
Du, Bingfan, Lowinger, Timothy B, Bodyak, Natalya D, Stevenson, Cheri A, Kozytska, Mariya, Yin, Mao, Yurkovetskiy, Aleksandr V, Gumerov, Dmitry R
Year of Publication 23.04.2024
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Year of Publication 23.04.2024
Patent