Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials
Spiegelberg, Linda, Houben, Ruud, Niemans, Raymon, de Ruysscher, Dirk, Yaromina, Ala, Theys, Jan, Guise, Christopher P., Smaill, Jeffrey B., Patterson, Adam V., Lambin, Philippe, Dubois, Ludwig J.
Published in Clinical and translational radiation oncology (01.02.2019)
Published in Clinical and translational radiation oncology (01.02.2019)
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Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302
Meng, Fanying, Evans, James W, Bhupathi, Deepthi, Banica, Monica, Lan, Leslie, Lorente, Gustavo, Duan, Jian-Xin, Cai, Xiaohong, Mowday, Alexandra M, Guise, Christopher P, Maroz, Andrej, Anderson, Robert F, Patterson, Adam V, Stachelek, Gregory C, Glazer, Peter M, Matteucci, Mark D, Hart, Charles P
Published in Molecular cancer therapeutics (01.03.2012)
Published in Molecular cancer therapeutics (01.03.2012)
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The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3
GUISE, Christopher P, ABBATTISTA, Maria R, DONATE, Fernando, WILSON, William R, PATTERSON, Adam V, SINGLETON, Rachelle S, HOLFORD, Samuel D, CONNOLLY, Joanna, DACHS, Gabi U, FOX, Stephen B, POLLOCK, Robert, HARVEY, Justin, GUILFORD, Parry
Published in Cancer research (Chicago, Ill.) (15.02.2010)
Published in Cancer research (Chicago, Ill.) (15.02.2010)
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Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents
Omran, Ziad, Guise, Chris P., Chen, Linwei, Rauch, Cyril, Abdalla, Ashraf N., Abdullah, Omeima, Sindi, Ikhlas A., Fischer, Peter M., Smaill, Jeff B., Patterson, Adam V., Liu, Yuxiu, Wang, Qingmin
Published in Molecules (Basel, Switzerland) (01.06.2021)
Published in Molecules (Basel, Switzerland) (01.06.2021)
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Journal Article
FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells
Su, Jiechuang, Guise, Christopher P, Wilson, William R
Published in Biochemical journal (15.05.2013)
Published in Biochemical journal (15.05.2013)
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Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity
Guise, Chris P, Abbattista, Maria R, Anderson, Robert F, Li, Dan, Taghipouran, Rana, Tsai, Angela, Lee, Su Jung, Smaill, Jeff B, Denny, William A, Hay, Michael P, Wilson, William R, Hicks, Kevin O, Patterson, Adam V
Published in Molecules (Basel, Switzerland) (22.10.2020)
Published in Molecules (Basel, Switzerland) (22.10.2020)
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Journal Article
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3
Abbattista, Maria R, Ashoorzadeh, Amir, Guise, Christopher P, Mowday, Alexandra M, Mittra, Rituparna, Silva, Shevan, Hicks, Kevin O, Bull, Matthew R, Jackson-Patel, Victoria, Lin, Xiaojing, Prosser, Gareth A, Lambie, Neil K, Dachs, Gabi U, Ackerley, David F, Smaill, Jeff B, Patterson, Adam V
Published in Pharmaceuticals (Basel, Switzerland) (26.11.2021)
Published in Pharmaceuticals (Basel, Switzerland) (26.11.2021)
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Journal Article
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications
Ashoorzadeh, Amir, Mowday, Alexandra M, Guise, Christopher P, Silva, Shevan, Bull, Matthew R, Abbattista, Maria R, Copp, Janine N, Williams, Elsie M, Ackerley, David F, Patterson, Adam V, Smaill, Jeff B
Published in Pharmaceuticals (Basel, Switzerland) (01.02.2022)
Published in Pharmaceuticals (Basel, Switzerland) (01.02.2022)
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Journal Article
Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum
Li, Shuyu, Spooner, Robert A, Allen, Stuart C H, Guise, Christopher P, Ladds, Graham, Schnöder, Tina, Schmitt, Manfred J, Lord, J Michael, Roberts, Lynne M
Published in Molecular biology of the cell (01.08.2010)
Published in Molecular biology of the cell (01.08.2010)
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Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia
Guise, Christopher P, Mowday, Alexandra M, Ashoorzadeh, Amir, Yuan, Ran, Lin, Wan-Hua, Wu, Dong-Hai, Smaill, Jeff B, Patterson, Adam V, Ding, Ke
Published in Ai zheng (01.02.2014)
Published in Ai zheng (01.02.2014)
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REAL-WORLD CLINICAL OUTCOMES ACCORDING TO DUAL ANTI-PLATELET THERAPY REGIMEN AMONG PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: SINGLE CENTER EXPERIENCE IN CANADA
de Hemptinne, Q, L'Allier, P.L, Jolicoeur, M, Asgar, A, Bonan, R, Crépeau, J, de Guise, P, Dorval, J, Doucet, S, Gallo, R, Gosselin, G, Grégoire, J, Ibrahim, R, Ly, H, Nosair, M, Tanguay, J
Published in Canadian journal of cardiology (01.10.2015)
Published in Canadian journal of cardiology (01.10.2015)
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Ion microprobe UPb zircon geochronology and isotopic evidence for a trans-crustal suture in the Lapland–Kola Orogen, northern Fennoscandian Shield
Daly, J.S, Balagansky, V.V, Timmerman, M.J, Whitehouse, M.J, de Jong, K, Guise, P, Bogdanova, S, Gorbatschev, R, Bridgwater, D
Published in Precambrian research (01.01.2001)
Published in Precambrian research (01.01.2001)
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Journal Article
Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy
Copp, Janine N., Mowday, Alexandra M., Williams, Elsie M., Guise, Christopher P., Ashoorzadeh, Amir, Sharrock, Abigail V., Flanagan, Jack U., Smaill, Jeff B., Patterson, Adam V., Ackerley, David F.
Published in Cell chemical biology (16.03.2017)
Published in Cell chemical biology (16.03.2017)
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Journal Article
Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506
van der Wiel, Alexander M A, Jackson-Patel, Victoria, Niemans, Raymon, Yaromina, Ala, Liu, Emily, Marcus, Damiënne, Mowday, Alexandra M, Lieuwes, Natasja G, Biemans, Rianne, Lin, Xiaojing, Fu, Zhe, Kumara, Sisira, Jochems, Arthur, Ashoorzadeh, Amir, Anderson, Robert F, Hicks, Kevin O, Bull, Matthew R, Abbattista, Maria R, Guise, Christopher P, Deschoemaeker, Sofie, Thiolloy, Sophie, Heyerick, Arne, Solivio, Morwena J, Balbo, Silvia, Smaill, Jeff B, Theys, Jan, Dubois, Ludwig J, Patterson, Adam V, Lambin, Philippe
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506
Ashoorzadeh, Amir, Mowday, Alexandra M., Abbattista, Maria R., Guise, Christopher P., Bull, Matthew R., Silva, Shevan, Patterson, Adam V., Smaill, Jeff B.
Published in ACS medicinal chemistry letters (09.11.2023)
Published in ACS medicinal chemistry letters (09.11.2023)
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Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours
Mowday, Alexandra M., Dubois, Ludwig J., Kubiak, Aleksandra M., Chan-Hyams, Jasmine V. E., Guise, Christopher P., Ashoorzadeh, Amir, Lambin, Philippe, Ackerley, David F., Smaill, Jeff B., Minton, Nigel P., Theys, Jan, Patterson, Adam V.
Published in Cancer gene therapy (01.02.2022)
Published in Cancer gene therapy (01.02.2022)
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Journal Article
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy
Williams, Elsie M, Rich, Michelle H, Mowday, Alexandra M, Ashoorzadeh, Amir, Copp, Janine N, Guise, Christopher P, Anderson, Robert F, Flanagan, Jack U, Smaill, Jeff B, Patterson, Adam V, Ackerley, David F
Published in Biochemistry (Easton) (03.09.2019)
Published in Biochemistry (Easton) (03.09.2019)
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Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit
Singleton, Dean C., Mowday, Alexandra M., Guise, Chris P., Syddall, Sophie P., Bai, Sally Y., Li, Dan, Ashoorzadeh, Amir, Smaill, Jeff B., Wilson, William R., Patterson, Adam V.
Published in Cancer gene therapy (01.07.2022)
Published in Cancer gene therapy (01.07.2022)
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