Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
Oballa, Renata M, Belair, Liette, Black, W. Cameron, Bleasby, Kelly, Chan, Chi Chung, Desroches, Carole, Du, Xiaobing, Gordon, Robert, Guay, Jocelyne, Guiral, Sebastien, Hafey, Michael J, Hamelin, Emelie, Huang, Zheng, Kennedy, Brian, Lachance, Nicolas, Landry, France, Li, Chun Sing, Mancini, Joseph, Normandin, Denis, Pocai, Alessandro, Powell, David A, Ramtohul, Yeeman K, Skorey, Kathryn, Sørensen, Dan, Sturkenboom, Wayne, Styhler, Angela, Waddleton, Deena M, Wang, Hao, Wong, Simon, Xu, Lijing, Zhang, Lei
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Interplay of the serine/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division
Fleurie, Aurore, Manuse, Sylvie, Zhao, Chao, Campo, Nathalie, Cluzel, Caroline, Lavergne, Jean-Pierre, Freton, Céline, Combet, Christophe, Guiral, Sébastien, Soufi, Boumediene, Macek, Boris, Kuru, Erkin, VanNieuwenhze, Michael S, Brun, Yves V, Di Guilmi, Anne-Marie, Claverys, Jean-Pierre, Galinier, Anne, Grangeasse, Christophe
Published in PLoS genetics (01.04.2014)
Published in PLoS genetics (01.04.2014)
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Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization
Lavoie, Hugo, Thevakumaran, Neroshan, Gavory, Gwenaëlle, Li, John J, Padeganeh, Abbas, Guiral, Sébastien, Duchaine, Jean, Mao, Daniel Y L, Bouvier, Michel, Sicheri, Frank, Therrien, Marc
Published in Nature chemical biology (01.07.2013)
Published in Nature chemical biology (01.07.2013)
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Autophosphorylation of the Bacterial Tyrosine-Kinase CpsD Connects Capsule Synthesis with the Cell Cycle in Streptococcus pneumoniae
Nourikyan, Julien, Kjos, Morten, Mercy, Chryslène, Cluzel, Caroline, Morlot, Cécile, Noirot-Gros, Marie-Francoise, Guiral, Sébastien, Lavergne, Jean-Pierre, Veening, Jan-Willem, Grangeasse, Christophe
Published in PLoS genetics (01.09.2015)
Published in PLoS genetics (01.09.2015)
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Oral-Hygiene-Related Mobile Apps in the French App Stores: Assessment of Functionality and Quality
Carrouel, Florence, Bourgeois, Denis, Clément, Céline, Tardivo, Delphine, Martinon, Prescilla, Guiral, Sébastien, Lan, Romain, Viennot, Stéphane, Dussart, Claude, Fraticelli, Laurie
Published in International journal of environmental research and public health (14.06.2022)
Published in International journal of environmental research and public health (14.06.2022)
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Competence-Programmed Predation of Noncompetent Cells in the Human Pathogen Streptococcus pneumoniae: Genetic Requirements
Guiral, Sébastien, Mitchell, Tim J., Martin, Bernard, Claverys, Jean-Pierre, Losick, Richard M.
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (14.06.2005)
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Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae
Diagne, Aissatou Maty, Pelletier, Anaïs, Durmort, Claire, Faure, Agathe, Kanonenberg, Kerstin, Freton, Céline, Page, Adeline, Delolme, Frédéric, Vorac, Jaroslav, Vallet, Sylvain, Bellard, Laure, Vivès, Corinne, Fieschi, Franck, Vernet, Thierry, Rousselle, Patricia, Guiral, Sébastien, Grangeasse, Christophe, Jault, Jean-Michel, Orelle, Cédric
Published in PLoS pathogens (01.04.2022)
Published in PLoS pathogens (01.04.2022)
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Mutational dissection of the S/T-kinase StkP reveals crucial roles in cell division of Streptococcus pneumoniae
Fleurie, Aurore, Cluzel, Caroline, Guiral, Sébastien, Freton, Céline, Galisson, Frédéric, Zanella-Cleon, Isabelle, Di Guilmi, Anne-Marie, Grangeasse, Christophe
Published in Molecular microbiology (01.02.2012)
Published in Molecular microbiology (01.02.2012)
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MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
Xu, Daigen, Rowland, Steven E, Clark, Patsy, Giroux, André, Côté, Bernard, Guiral, Sébastien, Salem, Myriam, Ducharme, Yves, Friesen, Richard W, Méthot, Nathalie, Mancini, Joseph, Audoly, Laurent, Riendeau, Denis
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay
Normandin, Karine, Lavallée, Jean-François, Futter, Marie, Beautrait, Alexandre, Duchaine, Jean, Guiral, Sébastien, Marinier, Anne, Archambault, Vincent
Published in Scientific reports (22.11.2016)
Published in Scientific reports (22.11.2016)
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Critical Role of Dispensable Genes in Mycoplasma agalactiae Interaction with Mammalian Cells
Baranowski, Eric, Guiral, Sébastien, Sagné, Eveline, Skapski, Agnès, Citti, Christine
Published in Infection and Immunity (01.04.2010)
Published in Infection and Immunity (01.04.2010)
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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
Côté, Bernard, Burch, Jason D., Asante-Appiah, Ernest, Bayly, Chris, Bédard, Leanne, Blouin, Marc, Campeau, Louis-Charles, Cauchon, Elizabeth, Chan, Manuel, Chefson, Amandine, Coulombe, Nathalie, Cromlish, Wanda, Debnath, Smita, Deschênes, Denis, Dupont-Gaudet, Kristina, Falgueyret, Jean-Pierre, Forget, Robert, Gagné, Sébastien, Gauvreau, Danny, Girardin, Melina, Guiral, Sébastien, Langlois, Eric, Li, Chun Sing, Nguyen, Natalie, Papp, Rob, Plamondon, Serge, Roy, Amélie, Roy, Stéphanie, Seliniotakis, Ria, St-Onge, Miguel, Ouellet, Stéphane, Tawa, Paul, Truchon, Jean-François, Vacca, Joe, Wrona, Marc, Yan, Youwei, Ducharme, Yves
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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The Tyrosine-Autokinase UbK Is Required for Proper Cell Growth and Cell Morphology of Streptococcus pneumoniae
Pelletier, Anaïs, Freton, Céline, Gallay, Clément, Trouve, Jennyfer, Cluzel, Caroline, Franz-Wachtel, Mirita, Macek, Boris, Jault, Jean-Michel, Grangeasse, Christophe, Guiral, Sébastien
Published in Frontiers in microbiology (03.09.2019)
Published in Frontiers in microbiology (03.09.2019)
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Journal Article
Genome-scale analysis of Mycoplasma agalactiae loci involved in interaction with host cells
Skapski, Agnès, Hygonenq, Marie-Claude, Sagné, Eveline, Guiral, Sébastien, Citti, Christine, Baranowski, Eric
Published in PloS one (23.09.2011)
Published in PloS one (23.09.2011)
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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
Côté, Bernard, Boulet, Louise, Brideau, Christine, Claveau, David, Ethier, Diane, Frenette, Richard, Gagnon, Marc, Giroux, André, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Martins, Evelyn, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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Journal Article
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors
Giroux, André, Boulet, Louise, Brideau, Christine, Chau, Anh, Claveau, David, Côté, Bernard, Ethier, Diane, Frenette, Richard, Gagnon, Marc, Guay, Jocelyne, Guiral, Sébastien, Mancini, Joseph, Martins, Evelyn, Massé, Frédéric, Méthot, Nathalie, Riendeau, Denis, Rubin, Joel, Xu, Daigen, Yu, Hongping, Ducharme, Yves, Friesen, Richard W.
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
Published in Bioorganic & medicinal chemistry letters (15.10.2009)
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PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae
Zucchini, Laure, Mercy, Chryslène, Garcia, Pierre Simon, Cluzel, Caroline, Gueguen-Chaignon, Virginie, Galisson, Frédéric, Freton, Céline, Guiral, Sébastien, Brochier-Armanet, Céline, Gouet, Patrice, Grangeasse, Christophe
Published in Nature microbiology (01.02.2018)
Published in Nature microbiology (01.02.2018)
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Journal Article
Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells
Dagkessamanskaia, Adilia, Moscoso, Miriam, Hénard, Vincent, Guiral, Sébastien, Overweg, Karin, Reuter, Mark, Martin, Bernard, Wells, Jerry, Claverys, Jean‐Pierre
Published in Molecular microbiology (01.02.2004)
Published in Molecular microbiology (01.02.2004)
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Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)
Léger, Serge, Black, W. Cameron, Deschenes, Denis, Dolman, Sarah, Falgueyret, Jean-Pierre, Gagnon, Marc, Guiral, Sébastien, Huang, Zheng, Guay, Jocelyne, Leblanc, Yves, Li, Chun-Sing, Massé, Frédéric, Oballa, Renata, Zhang, Lei
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Autophosphorylation of the Bacterial Tyrosine-Kinase CpsD Connects Capsule Synthesis with the Cell Cycle in Streptococcus pneumoniae: e1005518
Nourikyan, Julien, Kjos, Morten, Mercy, Chryslène, Cluzel, Caroline, Morlot, Cécile, Noirot-Gros, Marie-Francoise, Guiral, Sébastien, Lavergne, Jean-Pierre, Veening, Jan-Willem, Grangeasse, Christophe
Published in PLoS genetics (01.09.2015)
Published in PLoS genetics (01.09.2015)
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