Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells
Wünnemann, Florian, Fotsing Tadjo, Thierry, Beaudoin, Mélissa, Lalonde, Simon, Lo, Ken Sin, Kleinstiver, Benjamin P, Lettre, Guillaume
Published in PLoS genetics (16.03.2023)
Published in PLoS genetics (16.03.2023)
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Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci
Lessard, Samuel, Francioli, Laurent, Alfoldi, Jessica, Tardif, Jean-Claude, Ellinor, Patrick T., MacArthur, Daniel G., Lettre, Guillaume, Orkin, Stuart H., Canver, Matthew C.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2017)
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Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically
Wang, Jian, Dron, Jacqueline S, Ban, Matthew R, Robinson, John F, McIntyre, Adam D, Alazzam, Maher, Zhao, Pei Jun, Dilliott, Allison A, Cao, Henian, Huff, Murray W, Rhainds, David, Low-Kam, Cécile, Dubé, Marie-Pierre, Lettre, Guillaume, Tardif, Jean-Claude, Hegele, Robert A
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.2016)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.2016)
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Frameshift indels introduced by genome editing can lead to in-frame exon skipping
Lalonde, Simon, Stone, Oliver A, Lessard, Samuel, Lavertu, Adam, Desjardins, Jessica, Beaudoin, Mélissa, Rivas, Manuel, Stainier, Didier Y R, Lettre, Guillaume
Published in PloS one (01.06.2017)
Published in PloS one (01.06.2017)
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Genome partitioning of genetic variation for complex traits using common SNPs
Yang, Jian, Manolio, Teri A, Pasquale, Louis R, Boerwinkle, Eric, Caporaso, Neil, Cunningham, Julie M, de Andrade, Mariza, Feenstra, Bjarke, Feingold, Eleanor, Hayes, M Geoffrey, Hill, William G, Landi, Maria Teresa, Alonso, Alvaro, Lettre, Guillaume, Lin, Peng, Ling, Hua, Lowe, William, Mathias, Rasika A, Melbye, Mads, Pugh, Elizabeth, Cornelis, Marilyn C, Weir, Bruce S, Goddard, Michael E, Visscher, Peter M
Published in Nature genetics (01.06.2011)
Published in Nature genetics (01.06.2011)
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Polygenic determinants in extremes of high-density lipoprotein cholesterol
Dron, Jacqueline S., Wang, Jian, Low-Kam, Cécile, Khetarpal, Sumeet A., Robinson, John F., McIntyre, Adam D., Ban, Matthew R., Cao, Henian, Rhainds, David, Dubé, Marie-Pierre, Rader, Daniel J., Lettre, Guillaume, Tardif, Jean-Claude, Hegele, Robert A.
Published in Journal of lipid research (01.11.2017)
Published in Journal of lipid research (01.11.2017)
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Importance of genetic testing in unexplained cardiac arrest
Grondin, Steffany, Davies, Brianna, Cadrin-Tourigny, Julia, Steinberg, Christian, Cheung, Christopher C, Jorda, Paloma, Healey, Jeffrey S, Green, Martin S, Sanatani, Shubhayan, Alqarawi, Wael, Angaran, Paul, Arbour, Laura, Antiperovitch, Pavel, Khan, Habib, Leather, Richard, Guerra, Peter G, Rivard, Lena, Simpson, Christopher S, Gardner, Martin, MacIntyre, Ciorsti, Seifer, Colette, Fournier, Anne, Joza, Jacqueline, Gollob, Michael H, Lettre, Guillaume, Talajic, Mario, Laksman, Zachary W, Roberts, Jason D, Krahn, Andrew D, Tadros, Rafik
Published in European heart journal (21.08.2022)
Published in European heart journal (21.08.2022)
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Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease
Fava, Vinicius M., Xu, Yong Zhong, Lettre, Guillaume, Van Thuc, Nguyen, Orlova, Marianna, Thai, Vu Hong, Tao, Shao, Croteau, Nathalie, Eldeeb, Mohamed A., MacDougall, Emma J., Cambri, Geison, Lahiri, Ramanuj, Adams, Linda, Fon, Edward A., Trempe, Jean-François, Cobat, Aurélie, Alcaïs, Alexandre, Abel, Laurent, Schurr, Erwin
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2019)
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The genetics of platelet count and volume in humans
Eicher, John D., Lettre, Guillaume, Johnson, Andrew D.
Published in Platelets (Edinburgh) (17.02.2018)
Published in Platelets (Edinburgh) (17.02.2018)
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Genetic model testing and statistical power in population-based association studies of quantitative traits
Lettre, Guillaume, Lange, Christoph, Hirschhorn, Joel N.
Published in Genetic epidemiology (01.05.2007)
Published in Genetic epidemiology (01.05.2007)
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Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci
Canver, Matthew C, Lessard, Samuel, Pinello, Luca, Wu, Yuxuan, Ilboudo, Yann, Stern, Emily N, Needleman, Austen J, Galactéros, Frédéric, Brugnara, Carlo, Kutlar, Abdullah, McKenzie, Colin, Reid, Marvin, Chen, Diane D, Das, Partha Pratim, A Cole, Mitchel, Zeng, Jing, Kurita, Ryo, Nakamura, Yukio, Yuan, Guo-Cheng, Lettre, Guillaume, Bauer, Daniel E, Orkin, Stuart H
Published in Nature genetics (01.04.2017)
Published in Nature genetics (01.04.2017)
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DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
Lettre, Guillaume, Sankaran, Vijay G, Bezerra, Marcos André C, Araújo, Aderson S, Uda, Manuela, Sanna, Serena, Cao, Antonio, Schlessinger, David, Costa, Fernando F, Hirschhorn, Joel N, Orkin, Stuart H
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2008)
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An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility
Lessard, Samuel, Gatof, Emily Stern, Beaudoin, Mélissa, Schupp, Patrick G, Sher, Falak, Ali, Adnan, Prehar, Sukhpal, Kurita, Ryo, Nakamura, Yukio, Baena, Esther, Ledoux, Jonathan, Oceandy, Delvac, Bauer, Daniel E, Lettre, Guillaume
Published in The Journal of clinical investigation (01.08.2017)
Published in The Journal of clinical investigation (01.08.2017)
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Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon
Wonkam, Ambroise, Ngo Bitoungui, Valentina J, Vorster, Anna A, Ramesar, Raj, Cooper, Richard S, Tayo, Bamidele, Lettre, Guillaume, Ngogang, Jeanne
Published in PloS one (25.03.2014)
Published in PloS one (25.03.2014)
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Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene
Lalonde, Simon, Codina-Fauteux, Valérie-Anne, de Bellefon, Sébastian Méric, Leblanc, Francis, Beaudoin, Mélissa, Simon, Marie-Michelle, Dali, Rola, Kwan, Tony, Lo, Ken Sin, Pastinen, Tomi, Lettre, Guillaume
Published in Genome Biology (08.07.2019)
Published in Genome Biology (08.07.2019)
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Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia
Uda, Manuela, Galanello, Renzo, Sanna, Serena, Lettre, Guillaume, Sankaran, Vijay G, Chen, Weimin, Usala, Gianluca, Busonero, Fabio, Maschio, Andrea, Albai, Giuseppe, Piras, Maria Grazia, Sestu, Natascia, Lai, Sandra, Dei, Mariano, Mulas, Antonella, Crisponi, Laura, Naitza, Silvia, Asunis, Isadora, Deiana, Manila, Nagaraja, Ramaiah, Perseu, Lucia, Satta, Stefania, Cipollina, Maria Dolores, Sollaino, Carla, Moi, Paolo, Hirschhorn, Joel N, Orkin, Stuart H, Abecasis, Gonçalo R, Schlessinger, David, Cao, Antonio
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (05.02.2008)
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