Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
Bonnefond, Amélie, Clément, Nathalie, Fawcett, Katherine, Yengo, Loïc, Vaillant, Emmanuel, Guillaume, Jean-Luc, Dechaume, Aurélie, Payne, Felicity, Roussel, Ronan, Czernichow, Sébastien, Hercberg, Serge, Hadjadj, Samy, Balkau, Beverley, Marre, Michel, Lantieri, Olivier, Langenberg, Claudia, Bouatia-Naji, Nabila, Charpentier, Guillaume, Vaxillaire, Martine, Rocheleau, Ghislain, Wareham, Nicholas J, Sladek, Robert, McCarthy, Mark I, Dina, Christian, Barroso, Inês, Jockers, Ralf, Froguel, Philippe
Published in Nature genetics (01.03.2012)
Published in Nature genetics (01.03.2012)
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The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization
Levoye, Angélique, Dam, Julie, Ayoub, Mohammed A, Guillaume, Jean-Luc, Couturier, Cyril, Delagrange, Philippe, Jockers, Ralf
Published in The EMBO journal (12.07.2006)
Published in The EMBO journal (12.07.2006)
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Importance of the second extracellular loop for melatonin MT 1 receptor function and absence of melatonin binding in GPR50
Clement, Nathalie, Renault, Nicolas, Guillaume, Jean-Luc, Cecon, Erika, Journé, Anne-Sophie, Laurent, Xavier, Tadagaki, Kenjiro, Cogé, Francis, Gohier, Arnaud, Delagrange, Philippe, Chavatte, Philippe, Jockers, Ralf
Published in British journal of pharmacology (01.08.2018)
Published in British journal of pharmacology (01.08.2018)
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Journal Article
GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors
Ahmad, Raise, Lahuna, Olivier, Sidibe, Anissa, Daulat, Avais, Zhang, Qiang, Luka, Marine, Guillaume, Jean-Luc, Gallet, Sarah, Guillonneau, François, Hamroune, Juliette, Polo, Sophie, Prévot, Vincent, Delagrange, Philippe, Dam, Julie, Jockers, Ralf
Published in Cellular and molecular life sciences : CMLS (01.12.2020)
Published in Cellular and molecular life sciences : CMLS (01.12.2020)
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Journal Article
Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers
Kamal, Maud, Gbahou, Florence, Guillaume, Jean-Luc, Daulat, Avais M., Benleulmi-Chaachoua, Abla, Luka, Marine, Chen, Patty, Kalbasi Anaraki, Dina, Baroncini, Marc, Mannoury la Cour, Clotilde, Millan, Mark J., Prevot, Vincent, Delagrange, Philippe, Jockers, Ralf
Published in The Journal of biological chemistry (01.05.2015)
Published in The Journal of biological chemistry (01.05.2015)
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Journal Article
Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C‐terminal domain
Cecon, Erika, Ivanova, Anna, Luka, Marine, Gbahou, Florence, Friederich, Anne, Guillaume, Jean‐Luc, Keller, Patrick, Knoch, Klaus, Ahmad, Raise, Delagrange, Philippe, Solimena, Michele, Jockers, Ralf
Published in Journal of pineal research (01.03.2019)
Published in Journal of pineal research (01.03.2019)
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Journal Article
Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50
Clement, Nathalie, Renault, Nicolas, Guillaume, Jean‐Luc, Cecon, Erika, Journé, Anne‐Sophie, Laurent, Xavier, Tadagaki, Kenjiro, Cogé, Francis, Gohier, Arnaud, Delagrange, Philippe, Chavatte, Philippe, Jockers, Ralf
Published in British journal of pharmacology (01.08.2018)
Published in British journal of pharmacology (01.08.2018)
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Journal Article
The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
Wojciech, Stefanie, Ahmad, Raise, Belaid-Choucair, Zakia, Journé, Anne-Sophie, Gallet, Sarah, Dam, Julie, Daulat, Avais, Ndiaye-Lobry, Delphine, Lahuna, Olivier, Karamitri, Angeliki, Guillaume, Jean-Luc, Do Cruzeiro, Marcio, Guillonneau, François, Saade, Anastasia, Clément, Nathalie, Courivaud, Thomas, Kaabi, Nawel, Tadagaki, Kenjiro, Delagrange, Philippe, Prévot, Vincent, Hermine, Olivier, Prunier, Céline, Jockers, Ralf
Published in Nature communications (23.03.2018)
Published in Nature communications (23.03.2018)
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Journal Article
Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders
Chaste, Pauline, Clement, Nathalie, Botros, Hany Goubran, Guillaume, Jean-Luc, Konyukh, Marina, Pagan, Cécile, Scheid, Isabelle, Nygren, Gudrun, Anckarsäter, Henrik, Rastam, Maria, Ståhlberg, Ola, Gillberg, I. Carina, Melke, Jonas, Delorme, Richard, Leblond, Claire, Toro, Roberto, Huguet, Guillaume, Fauchereau, Fabien, Durand, Christelle, Boudarene, Lydia, Serrano, Emilie, Lemière, Nathalie, Launay, Jean Marie, Leboyer, Marion, Jockers, Ralf, Gillberg, Christopher, Bourgeron, Thomas
Published in Journal of pineal research (01.11.2011)
Published in Journal of pineal research (01.11.2011)
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Journal Article
GPCR-Interacting Proteins, Major Players of GPCR Function
Maurice, Pascal, Guillaume, Jean-Luc, Benleulmi-Chaachoua, Abla, Daulat, Avais M., Kamal, Maud, Jockers, Ralf
Published in Advances in Pharmacology (2011)
Published in Advances in Pharmacology (2011)
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Book Chapter
Journal Article
The PDZ Protein Mupp1 Promotes Gi Coupling and Signaling of the Mt1 Melatonin Receptor
Guillaume, Jean-Luc, Daulat, Avais M., Maurice, Pascal, Levoye, Angélique, Migaud, Martine, Brydon, Lena, Malpaux, Benoît, Borg-Capra, Catherine, Jockers, Ralf
Published in The Journal of biological chemistry (13.06.2008)
Published in The Journal of biological chemistry (13.06.2008)
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Journal Article
Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population
Chaste, Pauline, Clement, Nathalie, Mercati, Oriane, Guillaume, Jean-Luc, Delorme, Richard, Botros, Hany Goubran, Pagan, Cécile, Périvier, Samuel, Scheid, Isabelle, Nygren, Gudrun, Anckarsäter, Henrik, Rastam, Maria, Ståhlberg, Ola, Gillberg, Carina, Serrano, Emilie, Lemière, Nathalie, Launay, Jean Marie, Mouren-Simeoni, Marie Christine, Leboyer, Marion, Gillberg, Christopher, Jockers, Ralf, Bourgeron, Thomas
Published in PloS one (15.07.2010)
Published in PloS one (15.07.2010)
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Journal Article
Purification and Identification of G Protein-coupled Receptor Protein Complexes under Native Conditions
Daulat, Avais M., Maurice, Pascal, Froment, Carine, Guillaume, Jean-Luc, Broussard, Cédric, Monsarrat, Bernard, Delagrange, Philippe, Jockers, Ralf
Published in Molecular & cellular proteomics (01.05.2007)
Published in Molecular & cellular proteomics (01.05.2007)
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Journal Article
A Generic Approach for the Purification of Signaling Complexes That Specifically Interact with the Carboxyl-terminal Domain of G Protein-coupled Receptors
Maurice, Pascal, Daulat, Avais M., Broussard, Cédric, Mozo, Julien, Clary, Guilhem, Hotellier, Françoise, Chafey, Philippe, Guillaume, Jean-Luc, Ferry, Gilles, Boutin, Jean A., Delagrange, Philippe, Camoin, Luc, Jockers, Ralf
Published in Molecular & cellular proteomics (01.08.2008)
Published in Molecular & cellular proteomics (01.08.2008)
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Journal Article
Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function
Baba, Kenkichi, Benleulmi-Chaachoua, Abla, Journé, Anne-Sophie, Kamal, Maud, Guillaume, Jean-Luc, Dussaud, Sébastien, Gbahou, Florence, Yettou, Katia, Liu, Cuimei, Contreras-Alcantara, Susana, Jockers, Ralf, Tosini, Gianluca
Published in Science signaling (08.10.2013)
Published in Science signaling (08.10.2013)
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Journal Article
Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2 Receptor Variants with Type 2 Diabetes
Karamitri, Angeliki, Renault, Nicolas, Clement, Nathalie, Guillaume, Jean-Luc, Jockers, Ralf
Published in Molecular endocrinology (Baltimore, Md.) (01.08.2013)
Published in Molecular endocrinology (Baltimore, Md.) (01.08.2013)
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Journal Article
Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/Gi protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling
Maurice, Pascal, Daulat, Avais M, Turecek, Rostislav, Ivankova-Susankova, Klara, Zamponi, Francesco, Kamal, Maud, Clement, Nathalie, Guillaume, Jean-Luc, Bettler, Bernhard, Galès, Céline, Delagrange, Philippe, Jockers, Ralf
Published in The EMBO journal (03.11.2010)
Published in The EMBO journal (03.11.2010)
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Journal Article