Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents—synthesis, antiproliferative activity and inhibition of tubulin polymerization
Prinz, Helge, Schmidt, Peter, Böhm, Konrad J., Baasner, Silke, Müller, Klaus, Gerlach, Matthias, Günther, Eckhard G., Unger, Eberhard
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Published in Bioorganic & medicinal chemistry (15.07.2011)
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PEGylated Recombinant Aplysia punctata Ink Toxin Depletes Arginine and Lysine and Inhibits the Growth of Tumor Xenografts
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N-Benzoylated Phenoxazines and Phenothiazines: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization
Prinz, Helge, Chamasmani, Behfar, Vogel, Kirsten, Böhm, Konrad J, Aicher, Babette, Gerlach, Matthias, Günther, Eckhard G, Amon, Peter, Ivanov, Igor, Müller, Klaus
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A Convenient Synthesis of Novel 2,8-Disubstituted Pyrido[3,4-b]pyrazines Possessing Biological Activity
Antoine, Maud, Gerlach, Matthias, Guenther, Eckhard, Schuster, Tilmann, Czech, Michael, Seipelt, Irene, Marchand, Pascal
Published in Synthesis (Stuttgart) (02.01.2012)
Published in Synthesis (Stuttgart) (02.01.2012)
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Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells
Defaux, Julien, Antoine, Maud, Logé, Cédric, Le Borgne, Marc, Schuster, Tilmann, Seipelt, Irene, Aicher, Babette, Teifel, Michael, Günther, Eckhard, Gerlach, Matthias, Marchand, Pascal
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Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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Abstract 2877: Perifosine alone and in combination with antimetabolites interferes with NF-kB pathway activation in colon cancer cell lines
Aicher, Babette, Schmidt, Peter, Engel, Jürgen, Guenther, Eckhard G., Teifel, Michael
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Abstract 871: Dual inhibition of PI3K and Erk1/2 shows synergy and efficacy in human tumor cells, either by using drug combinations or novel dual PI3K/Erk inhibitors
Seipelt, Irene, Gerlach, Matthias, Blumenstein, Lars, Mueller, Gilbert, Guenther, Eckhard, Engel, Jürgen, Teifel, Michael
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives
Leepasert, Theerachart, Shahabi, Manochehr, Shanab, Karem, Schirmer, Eva, Holzer, Wolfgang, Spreitzer, Helmut, Aicher, Babette, Müller, Gilbert, Günther, Eckhard
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
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Efficient synthesis of novel disubstituted pyrido[3,4-b]pyrazines for the design of protein kinase inhibitors
Antoine, Maud, Schuster, Tilmann, Seipelt, Irene, Aicher, Babette, Teifel, Michael, Günther, Eckhard, Gerlach, Matthias, Marchand, Pascal
Published in MedChemComm (01.01.2016)
Published in MedChemComm (01.01.2016)
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Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives
Shahabi, Manochehr, Schirmer, Eva, Shanab, Karem, Leepasert, Theerachart, Ruzicka, Jana, Holzer, Wolfgang, Spreitzer, Helmut, Aicher, Babette, Schmidt, Peter, Blumenstein, Lars, Müller, Gilbert, Günther, Eckhard
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center
Maingot, Mathieu, Blayo, Anne-Laure, Denoyelle, Séverine, M’Kadmi, Céline, Damian, Marjorie, Mary, Sophie, Gagne, Didier, Sanchez, Pierre, Aicher, Babette, Schmidt, Peter, Müller, Gilbert, Teifel, Michael, Günther, Eckhard, Marie, Jacky, Banères, Jean-Louis, Martinez, Jean, Fehrentz, Jean-Alain
Published in Bioorganic & medicinal chemistry letters (15.05.2016)
Published in Bioorganic & medicinal chemistry letters (15.05.2016)
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New trisubstituted 1,2,4-triazoles as ghrelin receptor antagonists
Blayo, Anne-Laure, Maingot, Mathieu, Aicher, Babette, M’Kadmi, Céline, Schmidt, Peter, Müller, Gilbert, Teifel, Michael, Günther, Eckhard, Gagne, Didier, Denoyelle, Séverine, Martinez, Jean, Fehrentz, Jean-Alain
Published in Bioorganic & medicinal chemistry letters (01.01.2015)
Published in Bioorganic & medicinal chemistry letters (01.01.2015)
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Abstract 5476: LHRH receptor targeting as mechanism of anti-tumor activity for cytotoxic conjugates of Disorazol Z with the LHRH receptor agonistic peptide D-Lys6-LHRH
Aicher, Babette, Schuster, Tilmann, Blumenstein, Lars, Schubert, Antje, Gründker, Carsten, Engel, Joerg B., Ortmann, Olaf, Mueller, Rolf, Guenther, Eckhard, Gerlach, Matthias, Teifel, Michael
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Abstract 3563: A highly selective Erk1/2 Inhibitor with in-vivo anti tumor potency
Seipelt, Irene, Guenther, Eckhard, Blumenstein, Lars, Mueller, Gilbert, Schmidt, Peter, Aicher, Babette, Teifel, Michael, Gerlach, Matthias
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Discovery of 7-Aryl-Substituted (1,5-Naphthyridin-4-yl)ureas as Aurora Kinase Inhibitors
Defaux, Julien, Antoine, Maud, Le Borgne, Marc, Schuster, Tilmann, Seipelt, Irene, Aicher, Babette, Teifel, Michael, Günther, Eckhard, Gerlach, Matthias, Marchand, Pascal
Published in ChemMedChem (01.01.2014)
Published in ChemMedChem (01.01.2014)
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Sulfonate Derivatives of Naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-Anthracenone as Highly Active Antimicrotubule Agents. Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization
Zuse, Anne, Schmidt, Peter, Baasner, Silke, Böhm, Konrad J, Müller, Klaus, Gerlach, Matthias, Günther, Eckhard G, Unger, Eberhard, Prinz, Helge
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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10-(2-oxo-2-Phenylethylidene)-10H-anthracen-9-ones as Highly Active Antimicrotubule Agents: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization
Prinz, Helge, Schmidt, Peter, Böhm, Konrad J, Baasner, Silke, Müller, Klaus, Unger, Eberhard, Gerlach, Matthias, Günther, Eckhard G
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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