Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
Brown, Kirk M., Nair, Jayaprakash K., Janas, Maja M., Anglero-Rodriguez, Yesseinia I., Dang, Lan T. H., Peng, Haiyan, Theile, Christopher S., Castellanos-Rizaldos, Elena, Brown, Christopher, Foster, Donald, Kurz, Jeffrey, Allen, Jeffrey, Maganti, Rajanikanth, Li, Jing, Matsuda, Shigeo, Stricos, Matthew, Chickering, Tyler, Jung, Michelle, Wassarman, Kelly, Rollins, Jeff, Woods, Lauren, Kelin, Alex, Guenther, Dale C., Mobley, Melissa W., Petrulis, John, McDougall, Robin, Racie, Timothy, Bombardier, Jessica, Cha, Diana, Agarwal, Saket, Johnson, Lei, Jiang, Yongfeng, Lentini, Scott, Gilbert, Jason, Nguyen, Tuyen, Chigas, Samantha, LeBlanc, Sarah, Poreci, Urjana, Kasper, Anne, Rogers, Arlin B., Chong, Saeho, Davis, Wendell, Sutherland, Jessica E., Castoreno, Adam, Milstein, Stuart, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Keating, Mark, Manoharan, Muthiah, Fitzgerald, Kevin, Wu, Jing-Tao, Maier, Martin A., Jadhav, Vasant
Published in Nature biotechnology (01.10.2022)
Published in Nature biotechnology (01.10.2022)
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Journal Article
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing
Jahns, Hartmut, Degaonkar, Rohan, Podbevsek, Peter, Gupta, Swati, Bisbe, Anna, Aluri, Krishna, Szeto, John, Kumar, Pawan, LeBlanc, Sarah, Racie, Tim, Brown, Christopher R, Castoreno, Adam, Guenther, Dale C, Jadhav, Vasant, Maier, Martin A, Plavec, Janez, Egli, Martin, Manoharan, Muthiah, Zlatev, Ivan
Published in Nucleic acids research (11.10.2021)
Published in Nucleic acids research (11.10.2021)
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Journal Article
Recognition of double-stranded DNA using LNA-modified toehold Invader probes
Adhikari, Shiva P, Vukelich, Philip, Guenther, Dale C, Karmakar, Saswata, Hrdlicka, Patrick J
Published in Organic & biomolecular chemistry (03.11.2021)
Published in Organic & biomolecular chemistry (03.11.2021)
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Journal Article
Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway
Aluri, Krishna C., Datta, Dhrubajyoti, Waldron, Scott, Taneja, Nate, Qin, June, Donnelly, Daniel P., Theile, Christopher S., Guenther, Dale C., Lei, Li, Harp, Joel M., Pallan, Pradeep S., Egli, Martin, Zlatev, Ivan, Manoharan, Muthiah
Published in Journal of the American Chemical Society (07.10.2024)
Published in Journal of the American Chemical Society (07.10.2024)
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Journal Article
4′‑C‑Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing
Malek-Adamian, Elise, Guenther, Dale C, Matsuda, Shigeo, Martínez-Montero, Saúl, Zlatev, Ivan, Harp, Joel, Burai Patrascu, Mihai, Foster, Donald J, Fakhoury, Johans, Perkins, Lydia, Moitessier, Nicolas, Manoharan, Rajar M, Taneja, Nate, Bisbe, Anna, Charisse, Klaus, Maier, Martin, Rajeev, Kallanthottathil G, Egli, Martin, Manoharan, Muthiah, Damha, Masad J
Published in Journal of the American Chemical Society (18.10.2017)
Published in Journal of the American Chemical Society (18.10.2017)
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Journal Article
Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
Harp, Joel M, Guenther, Dale C, Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R, Zlatev, Ivan, Foster, Donald J, Taneja, Nate, Charisse, Klaus, Maier, Martin A, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Egli, Martin
Published in Nucleic acids research (19.09.2018)
Published in Nucleic acids research (19.09.2018)
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Journal Article
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease
Kumar, Pawan, Degaonkar, Rohan, Guenther, Dale C, Abramov, Mikhail, Schepers, Guy, Capobianco, Marie, Jiang, Yongfeng, Harp, Joel, Kaittanis, Charalambos, Janas, Maja M, Castoreno, Adam, Zlatev, Ivan, Schlegel, Mark K, Herdewijn, Piet, Egli, Martin, Manoharan, Muthiah
Published in Nucleic acids research (07.05.2020)
Published in Nucleic acids research (07.05.2020)
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Journal Article
Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Matsuda, Shigeo, Bala, Saikat, Liao, Jen-Yu, Datta, Dhrubajyoti, Mikami, Atsushi, Woods, Lauren, Harp, Joel M., Gilbert, Jason A., Bisbe, Anna, Manoharan, Rajar M., Kim, MaryBeth, Theile, Christopher S., Guenther, Dale C., Jiang, Yongfeng, Agarwal, Saket, Maganti, Rajanikanth, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Rajeev, Kallanthottathil G., Castoreno, Adam, Maier, Martin, Janas, Maja M., Egli, Martin, Chaput, John C., Manoharan, Muthiah
Published in Journal of the American Chemical Society (13.09.2023)
Published in Journal of the American Chemical Society (13.09.2023)
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Journal Article
Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β‑C‑methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects
Guenther, Dale C., Mori, Shohei, Matsuda, Shigeo, Gilbert, Jason A., Willoughby, Jennifer L. S., Hyde, Sarah, Bisbe, Anna, Jiang, Yongfeng, Agarwal, Saket, Madaoui, Mimouna, Janas, Maja M., Charisse, Klaus, Maier, Martin A., Egli, Martin, Manoharan, Muthiah
Published in Journal of the American Chemical Society (17.08.2022)
Published in Journal of the American Chemical Society (17.08.2022)
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Journal Article
Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2 '-triphenylene- and coronene-functionalized RNA monomers
Karmakar, Saswata, Guenther, Dale C., Gibbons, Bradley C., Hrdlicka, Patrick J.
Published in Organic & biomolecular chemistry (15.11.2017)
Published in Organic & biomolecular chemistry (15.11.2017)
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Journal Article
Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens
Denn, Benjamin, Karmakar, Saswata, Guenther, Dale C, Hrdlicka, Patrick J
Published in Chemical communications (Cambridge, England) (28.10.2013)
Published in Chemical communications (Cambridge, England) (28.10.2013)
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Journal Article
Synthesis and biophysical characterization of oligonucleotides modified with O2-alkylated RNA monomers featuring substituted pyrene moieties
Karmakar, Saswata, Horrocks, Tyler, Gibbons, Bradley C., Guenther, Dale C., Emehiser, Raymond, Hrdlicka, Patrick J.
Published in Organic & biomolecular chemistry (16.01.2019)
Published in Organic & biomolecular chemistry (16.01.2019)
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Journal Article
Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2-or 4-pyrenyl-functionalized O2 '-alkylated RNA monomers
Karmakar, Saswata, Madsen, Andreas S., Guenther, Dale C., Gibbons, Bradley C., Hrdlicka, Patrick J.
Published in Organic & biomolecular chemistry (21.10.2014)
Published in Organic & biomolecular chemistry (21.10.2014)
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Journal Article
Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications
Guenther, Dale C, Anderson, Grace H, Karmakar, Saswata, Anderson, Brooke A, Didion, Bradley A, Guo, Wei, Verstegen, John P, Hrdlicka, Patrick J
Published in Chemical science (Cambridge) (01.08.2015)
Published in Chemical science (Cambridge) (01.08.2015)
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