SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore
Guarnieri, Joseph W, Angelin, Alessia, Murdock, Deborah G, Schaefer, Patrick, Portluri, Prasanth, Lie, Timothy, Huang, Jessica, Wallace, Douglas C
Published in Frontiers in immunology (20.02.2023)
Published in Frontiers in immunology (20.02.2023)
Get full text
Journal Article
A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
Jamison, Jr, David A, Anand Narayanan, S, Trovão, Nídia S, Guarnieri, Joseph W, Topper, Michael J, Moraes-Vieira, Pedro M, Zaksas, Viktorija, Singh, Keshav K, Wurtele, Eve Syrkin, Beheshti, Afshin
Published in European journal of human genetics : EJHG (01.08.2022)
Published in European journal of human genetics : EJHG (01.08.2022)
Get full text
Journal Article
SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19
Guarnieri, Joseph W., Haltom, Jeffrey A., Albrecht, Yentli E. Soto, Lie, Timothy, Olali, Arnold Z., Widjaja, Gabrielle A., Ranshing, Sujata S., Angelin, Alessia, Murdock, Deborah, Wallace, Douglas C.
Published in Pharmacological research (01.06.2024)
Published in Pharmacological research (01.06.2024)
Get full text
Journal Article
Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts
Guarnieri, Joseph W, Dybas, Joseph M, Fazelinia, Hossein, Kim, Man S, Frere, Justin, Zhang, Yuanchao, Soto Albrecht, Yentli, Murdock, Deborah G, Angelin, Alessia, Singh, Larry N, Weiss, Scott L, Best, Sonja M, Lott, Marie T, Zhang, Shiping, Cope, Henry, Zaksas, Victoria, Saravia-Butler, Amanda, Meydan, Cem, Foox, Jonathan, Mozsary, Christopher, Bram, Yaron, Kidane, Yared, Priebe, Waldemar, Emmett, Mark R, Meller, Robert, Demharter, Sam, Stentoft-Hansen, Valdemar, Salvatore, Marco, Galeano, Diego, Enguita, Francisco J, Grabham, Peter, Trovao, Nidia S, Singh, Urminder, Haltom, Jeffrey, Heise, Mark T, Moorman, Nathaniel J, Baxter, Victoria K, Madden, Emily A, Taft-Benz, Sharon A, Anderson, Elizabeth J, Sanders, Wes A, Dickmander, Rebekah J, Baylin, Stephen B, Wurtele, Eve Syrkin, Moraes-Vieira, Pedro M, Taylor, Deanne, Mason, Christopher E, Schisler, Jonathan C, Schwartz, Robert E, Beheshti, Afshin, Wallace, Douglas C
Published in Science translational medicine (09.08.2023)
Published in Science translational medicine (09.08.2023)
Get more information
Journal Article
Role of miR-2392 in driving SARS-CoV-2 infection
McDonald, J. Tyson, Enguita, Francisco J., Taylor, Deanne, Griffin, Robert J., Priebe, Waldemar, Emmett, Mark R., Sajadi, Mohammad M., Harris, Anthony D., Clement, Jean, Dybas, Joseph M., Aykin-Burns, Nukhet, Guarnieri, Joseph W., Singh, Larry N., Grabham, Peter, Baylin, Stephen B., Yousey, Aliza, Pearson, Andrea N., Corry, Peter M., Saravia-Butler, Amanda, Aunins, Thomas R., Sharma, Sadhana, Nagpal, Prashant, Meydan, Cem, Foox, Jonathan, Mozsary, Christopher, Cerqueira, Bianca, Zaksas, Viktorija, Singh, Urminder, Wurtele, Eve Syrkin, Costes, Sylvain V., Davanzo, Gustavo Gastão, Galeano, Diego, Paccanaro, Alberto, Meinig, Suzanne L., Hagan, Robert S., Bowman, Natalie M., Wallet, Shannon M., Maile, Robert, Wolfgang, Matthew C., Hagan, Robert S., Mock, Jason R., Bowman, Natalie M., Torres-Castillo, Jose L., Love, Miriya K., Meinig, Suzanne L., Lovell, Will, Rice, Colleen, Mitchem, Olivia, Burgess, Dominique, Suggs, Jessica, Jacobs, Jordan, Wolfgang, Matthew C., Altinok, Selin, Sapoval, Nicolae, Treangen, Todd J., Moraes-Vieira, Pedro M., Vanderburg, Charles, Wallace, Douglas C., Schisler, Jonathan C., Mason, Christopher E., Chatterjee, Anushree, Meller, Robert, Beheshti, Afshin
Published in Cell reports (Cambridge) (19.10.2021)
Published in Cell reports (Cambridge) (19.10.2021)
Get full text
Journal Article
Mitochondrial antioxidants abate SARS-COV-2 pathology in mice
Guarnieri, Joseph W, Lie, Timothy, Albrecht, Yentli E Soto, Hewin, Peter, Jurado, Kellie A, Widjaja, Gabrielle A, Zhu, Yi, McManus, Meagan J, Kilbaugh, Todd J, Keith, Kelsey, Potluri, Prasanth, Taylor, Deanne, Angelin, Alessia, Murdock, Deborah G, Wallace, Douglas C
Published in Proceedings of the National Academy of Sciences - PNAS (23.07.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (23.07.2024)
Get full text
Journal Article
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
Houerbi, Nadia, Kim, JangKeun, Overbey, Eliah G., Batra, Richa, Schweickart, Annalise, Patras, Laura, Lucotti, Serena, Ryon, Krista A., Najjar, Deena, Meydan, Cem, Damle, Namita, Chin, Christopher, Narayanan, S. Anand, Guarnieri, Joseph W., Widjaja, Gabrielle, Beheshti, Afshin, Tobias, Gabriel, Vatter, Fanny, Hirschberg, Jeremy Wain, Kleinman, Ashley, Afshin, Evan E., MacKay, Matthew, Chen, Qiuying, Miller, Dawson, Gajadhar, Aaron S., Williamson, Lucy, Tandel, Purvi, Yang, Qiu, Chu, Jessica, Benz, Ryan, Siddiqui, Asim, Hornburg, Daniel, Gross, Steven, Shirah, Bader, Krumsiek, Jan, Mateus, Jaime, Mao, Xiao, Matei, Irina, Mason, Christopher E.
Published in Nature communications (11.06.2024)
Published in Nature communications (11.06.2024)
Get full text
Journal Article
A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection
Narayanan, S Anand, Jamison, Jr, David A, Guarnieri, Joseph W, Zaksas, Victoria, Topper, Michael, Koutnik, Andrew P, Park, Jiwoon, Clark, Kevin B, Enguita, Francisco J, Leitão, Ana Lúcia, Das, Saswati, Moraes-Vieira, Pedro M, Galeano, Diego, Mason, Christopher E, Trovão, Nídia S, Schwartz, Robert E, Schisler, Jonathan C, Coelho-Dos-Reis, Jordana G A, Wurtele, Eve Syrkin, Beheshti, Afshin
Published in European journal of human genetics : EJHG (01.01.2024)
Published in European journal of human genetics : EJHG (01.01.2024)
Get full text
Journal Article
Space radiation damage rescued by inhibition of key spaceflight associated miRNAs
McDonald, J. Tyson, Kim, JangKeun, Farmerie, Lily, Johnson, Meghan L., Trovao, Nidia S., Arif, Shehbeel, Siew, Keith, Tsoy, Sergey, Bram, Yaron, Park, Jiwoon, Overbey, Eliah, Ryon, Krista, Haltom, Jeffrey, Singh, Urminder, Enguita, Francisco J., Zaksas, Victoria, Guarnieri, Joseph W., Topper, Michael, Wallace, Douglas C., Meydan, Cem, Baylin, Stephen, Meller, Robert, Muratani, Masafumi, Porterfield, D. Marshall, Kaufman, Brett, Mori, Marcelo A., Walsh, Stephen B., Sigaudo-Roussel, Dominique, Mebarek, Saida, Bottini, Massimo, Marquette, Christophe A., Wurtele, Eve Syrkin, Schwartz, Robert E., Galeano, Diego, Mason, Christopher E., Grabham, Peter, Beheshti, Afshin
Published in Nature communications (11.06.2024)
Published in Nature communications (11.06.2024)
Get full text
Journal Article
PET Imaging with [ 18 F]ROStrace Detects Oxidative Stress and Predicts Parkinson's Disease Progression in Mice
Zhu, Yi, Kohli, Neha, Young, Anthony, Sheldon, Malkah, Coni, Jani, Rajasekaran, Meera, Robinson, Lozen, Chroneos, Rea, Riley, Shaipreeah, Guarnieri, Joseph W, Jose, Joshua, Patel, Nisha, Wallace, Douglas C, Li, Shihong, Lee, Hsiaoju, Mach, Robert H, McManus, Meagan J
Published in Antioxidants (12.10.2024)
Published in Antioxidants (12.10.2024)
Get full text
Journal Article
Author Correction: To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants
Corti, Giada, Kim, JangKeun, Enguita, Francisco J., Guarnieri, Joseph W., Grossman, Lawrence I., Costes, Sylvain V., Fuentealba, Matias, Scott, Ryan T., Magrini, Andrea, Sanders, Lauren M., Singh, Kanhaiya, Sen, Chandan K., Juran, Cassandra M., Paul, Amber M., Furman, David, Calleja-Agius, Jean, Mason, Christopher E., Galeano, Diego, Bottini, Massimo, Beheshti, Afshin
Published in Communications biology (16.10.2024)
Published in Communications biology (16.10.2024)
Get full text
Journal Article
To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants
Corti, Giada, Kim, JangKeun, Enguita, Francisco J., Guarnieri, Joseph W., Grossman, Lawrence I., Costes, Sylvain V., Fuentealba, Matias, Scott, Ryan T., Magrini, Andrea, Sanders, Lauren M., Singh, Kanhaiya, Sen, Chandan K., Juran, Cassandra M., Paul, Amber M., Furman, David, Calleja-Agius, Jean, Mason, Christopher E., Galeano, Diego, Bottini, Massimo, Beheshti, Afshin
Published in Communications biology (05.10.2024)
Published in Communications biology (05.10.2024)
Get full text
Journal Article
Enhanced Bioavailability of Itraconazole in Hydroxypropylβ-Cyclodextrin Solution versus Capsules in Healthy Volunteers
BARONE, J. A, MOSKOVITZ, B. L, GUARNIERI, J, HASSELL, A. E, COLAIZZI, J. L, BIERMAN, R. H, JESSEN, L
Published in Antimicrobial Agents and Chemotherapy (01.07.1998)
Published in Antimicrobial Agents and Chemotherapy (01.07.1998)
Get full text
Journal Article
ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer
Stojanovic, Lora, Abbotts, Rachel, Tripathi, Kaushlendra, Coon, Collin M, Rajendran, Saranya, Farid, Elnaz Abbasi, Hostetter, Galen, Guarnieri, Joseph W, Wallace, Douglas C, Liu, Sheng, Wan, Jun, Calendo, Gennaro, Marker, Rebecca, Gohari, Zahra, Inayatullah, Mohammed M A, Tiwari, Vijay K, Kader, Tanjina, Santagata, Sandro, Drapkin, Ronny, Kommoss, Stefan, Pfisterer, Jacobus, Konecny, Gottfried E, Coopergard, Ryan, Issa, Jean-Pierre, Winterhoff, Boris J N, Topper, Michael J, Sandusky, George E, Miller, Kathy D, Baylin, Stephen B, Nephew, Kenneth P, Rassool, Feyruz V
Published in bioRxiv (21.10.2024)
Published in bioRxiv (21.10.2024)
Get full text
Journal Article
TARGETED DOWN REGULATION OF CORE MITOCHONDRIAL GENES DURING SARS-COV-2 INFECTION
Guarnieri, Joseph W, Dybas, Joseph M, Fazelinia, Hossein, Kim, Man S, Frere, Justin, Zhang, Yuanchao, Albrecht, Yentli Soto, Murdock, Deborah G, Angelin, Alessia, Singh, Larry N, Weiss, Scott L, Best, Sonja M, Lott, Marie T, Cope, Henry, Zaksas, Viktorija, Saravia-Butler, Amanda, Meydan, Cem, Foox, Jonathan, Mozsary, Christopher, Kidane, Yared H, Priebe, Waldemar, Emmett, Mark R, Meller, Robert, Singh, Urminder, Bram, Yaron, tenOever, Benjamin R, Heise, Mark T, Moorman, Nathaniel J, Madden, Emily A, Taft-Benz, Sharon A, Anderson, Elizabeth J, Sanders, Wes A, Dickmander, Rebekah J, Baxter, Victoria K, Baylin, Stephen B, Wurtele, Eve Syrkin, Moraes-Vieira, Pedro M, Taylor, Deanne, Mason, Christopher E, Schisler, Jonathan C, Schwartz, Robert E, Beheshti, Afshin, Wallace, Douglas C
Published in bioRxiv (22.02.2022)
Published in bioRxiv (22.02.2022)
Get full text
Journal Article
Paper
The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection
McDonald, J Tyson, Enguita, Francisco Javier, Taylor, Deanne, Griffin, Robert J, Priebe, Waldemar, Emmett, Mark R, Sajadi, Mohammad M, Harris, Anthony D, Clement, Jean, Dybas, Joseph M, Aykin-Burns, Nukhet, Guarnieri, Joseph W, Singh, Larry N, Grabham, Peter, Baylin, Stephen B, Yousey, Aliza, Pearson, Andrea N, Corry, Peter M, Saravia-Butler, Amanda, Aunins, Thomas R, Sharma, Sadhana, Nagpal, Prashant, Meydan, Cem, Foox, Jonathan, Mozsary, Christopher, Cerqueira, Bianca, Zaksas, Viktorija, Singh, Urminder, Wurtele, Eve Syrkin, Costes, Sylvain V, Davanzo, Gustavo Gastão, Galeano, Diego, Paccanaro, Alberto, Meinig, Suzanne L, Hagan, Robert S, Bowman, Natalie M, Wolfgang, Matthew C, Altinok, Selin, Sapoval, Nicolae, Treangen, Todd J, Moraes-Vieira, Pedro M, Vanderburg, Charles, Wallace, Douglas C, Schisler, Jonathan, Mason, Christopher E, Chatterjee, Anushree, Meller, Robert, Beheshti, Afshin
Published in bioRxiv (18.08.2021)
Published in bioRxiv (18.08.2021)
Get full text
Journal Article
Paper
PET Imaging with 18FROStrace Detects Oxidative Stress and Predicts Parkinson's Disease Progression in Mice
Zhu, Yi, Kohli, Neha, Young, Anthony, Sheldon, Malkah, Coni, Jani, Rajasekaran, Meera, Robinson, Lozen, Chroneos, Rea, Riley, Shaipreeah, Guarnieri, Joseph W, Jose, Joshua, Patel, Nisha, Wallace, Douglas C, Li, Shihong, Lee, Hsiaoju, Mach, Robert H, McManus, Meagan J
Published in Antioxidants (12.10.2024)
Published in Antioxidants (12.10.2024)
Get full text
Journal Article
Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine
Muccilli, Samantha G, Schwarz, Bejamin, Jessop, Forrest, Shannon, Jeffrey G, Bohrnsen, Eric, Shue, Byron, Hong, Seon-Hui, Hsu, Thomas, Ashbrook, Alison W, Guarnieri, Joseph W, Lack, Justin, Wallace, Douglas C, Bosio, Catharine M, MacDonald, Margaret R, Rice, Charles M, Yewdell, Jonathan W, Best, Sonja M
Published in bioRxiv (15.09.2024)
Published in bioRxiv (15.09.2024)
Get full text
Journal Article
SARS-CoV-2 Orphan Gene ORF10 Contributes to More Severe COVID-19 Disease
Haltom, Jeffrey, Trovao, Nidia S, Guarnieri, Joseph, Vincent, Pan, Singh, Urminder, Tsoy, Sergey, O'Leary, Collin A, Bram, Yaron, Widjaja, Gabrielle A, Cen, Zimu, Meller, Robert, Baylin, Stephen B, Moss, Walter N, Nikolau, Basil J, Enguita, Francisco J, Wallace, Douglas C, Beheshti, Afshin, Schwartz, Robert, Wurtele, Eve Syrkin
Published in medRxiv : the preprint server for health sciences (27.11.2023)
Get more information
Published in medRxiv : the preprint server for health sciences (27.11.2023)
Journal Article