Anti-tumor Activity of Toll-Like Receptor 7 Agonists
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Published in Frontiers in pharmacology (31.05.2017)
Published in Frontiers in pharmacology (31.05.2017)
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Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats
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Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats
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Published in Biomedicine & pharmacotherapy (01.12.2018)
Published in Biomedicine & pharmacotherapy (01.12.2018)
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A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model
Hu, Yunlong, Tang, Li, Zhu, Zhengyu, Meng, He, Chen, Tingting, Zhao, Sheng, Jin, Zhenchao, Wang, Zhulin, Jin, Guangyi
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Published in Journal of translational medicine (04.03.2020)
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Gastric cancer vaccines synthesized using a TLR7 agonist and their synergistic antitumor effects with 5-fluorouracil
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Published in Journal of translational medicine (08.05.2018)
Published in Journal of translational medicine (08.05.2018)
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Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia
Wu, Raymond P., Hayashi, Tomoko, Cottam, Howard B., Jin, Guangyi, Yao, Shiyin, Wu, Christina C. N., Rosenbach, Michael D., Corr, Maripat, Schwab, Richard B., Carson, Dennis A.
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Published in Proceedings of the National Academy of Sciences - PNAS (20.04.2010)
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
Yu, Xiaolu, Long, Yiru, Chen, Binfan, Tong, Yongliang, Shan, Mengwen, Jia, Xiaomin, Hu, Chao, Liu, Meng, Zhou, Ji, Tang, Feng, Lu, Henglei, Chen, Runqiu, Xu, Pan, Huang, Wei, Ren, Jin, Wan, Yakun, Sun, Jianhua, Li, Jia, Jin, Guangyi, Gong, Likun
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Published in Journal for immunotherapy of cancer (01.10.2022)
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A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist
Chi, Huju, Hao, Yue, Wang, Xia, Tang, Li, Deng, Yongqiang, Chen, Xianxiong, Gao, Feng, Sha, Ou, Jin, Guangyi
Published in Cells (Basel, Switzerland) (21.06.2022)
Published in Cells (Basel, Switzerland) (21.06.2022)
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Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages
Du, Yongkun, Du, Taofeng, Shi, Yunpeng, Zhang, Angke, Zhang, Chong, Diao, Yuwen, Jin, Guangyi, Zhou, En-Min
Published in Antiviral research (01.07.2016)
Published in Antiviral research (01.07.2016)
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CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity
Long, Yiru, Sun, Jianhua, Song, Tian-Zhang, Liu, Tingting, Tang, Feng, Zhang, Xinxin, Ding, Longfei, Miao, Yunqiu, Zhu, Weiliang, Pan, Xiaoyan, An, Qi, Qin, Mian, Tong, Xiankun, Peng, Xionghua, Yu, Pan, Zhu, Peng, Xu, Jianqing, Zhang, Xiaoyan, Zhang, Yachun, Liu, Datao, Chen, Ben, Chen, Huilin, Zhang, Leike, Xiao, Gengfu, Zuo, Jianping, Tang, Wei, Zhou, Ji, Li, Heng, Xu, Zhijian, Zheng, Hong-Yi, Long, Xin-Yan, Qin, Qiuping, Gan, Yong, Ren, Jin, Huang, Wei, Zheng, Yong-Tang, Jin, Guangyi, Gong, Likun
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Published in Cell discovery (01.02.2022)
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Oxaliplatin-Based Platinum(IV) Prodrug Bearing Toll-like Receptor 7 Agonist for Enhanced Immunochemotherapy
Tang, Li, Cai, Demin, Qin, Mian, Lu, Shuo, Hu, Ming-Hao, Ruan, Shuangchen, Jin, Guangyi, Wang, Zhigang
Published in ACS omega (14.01.2020)
Published in ACS omega (14.01.2020)
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Inhibition of Cytokine Production by Hymenialdisine Derivatives
Sharma, Vasudha, Lansdell, Theresa A, Jin, Guangyi, Tepe, Jetze J
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
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Design, Synthesis, and Evaluation of 9-d-Ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones Bearing Alkyl Phosphate and α,α-Difluorophosphonate Substituents as Inhibitors of Riboflavin Synthase and Lumazine Synthase
Cushman, Mark, Sambaiah, Thota, Jin, Guangyi, Illarionov, Boris, Fischer, Markus, Bacher, Adelbert
Published in Journal of organic chemistry (06.02.2004)
Published in Journal of organic chemistry (06.02.2004)
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A New Series of N-[2,4-Dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography, and Mechanistic Implications
Zhang, Yanlei, Illarionov, Boris, Morgunova, Ekaterina, Jin, Guangyi, Bacher, Adelbert, Fischer, Markus, Ladenstein, Rudolf, Cushman, Mark
Published in Journal of organic chemistry (04.04.2008)
Published in Journal of organic chemistry (04.04.2008)
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Crystal Structure of Lumazine Synthase from Mycobacterium tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors
Morgunova, Ekaterina, Meining, Winfried, Illarionov, Boris, Haase, Ilka, Jin, Guangyi, Bacher, Adelbert, Cushman, Mark, Fischer, Markus, Ladenstein, Rudolf
Published in Biochemistry (Easton) (01.03.2005)
Published in Biochemistry (Easton) (01.03.2005)
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Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7
Hayashi, Tomoko, Cottam, Howard B, Chan, Michael, Jin, Guangyi, Tawatao, Rommel I, Crain, Brian, Ronacher, Lisa, Messer, Karen, Carson, Dennis A, Corr, Maripat
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.07.2008)
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.07.2008)
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