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A Structural and in Vitro Characterization of Asoprisnil: A Selective Progesterone Receptor Modulator
Madauss, Kevin P, Grygielko, Eugene T, Deng, Su-Jun, Sulpizio, Anthony C, Stanley, Thomas B, Wu, Charlene, Short, Steve A, Thompson, Scott K, Stewart, Eugene L, Laping, Nicholas J, Williams, Shawn P, Bray, Jeffrey D
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Published in Molecular endocrinology (Baltimore, Md.) (01.05.2007)
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Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis
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Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities
Doe, Chris, Bentley, Ross, Behm, David J, Lafferty, Robert, Stavenger, Robert, Jung, David, Bamford, Mark, Panchal, Terry, Grygielko, Eugene, Wright, Lois L, Smith, Gary K, Chen, Zunxuan, Webb, Christine, Khandekar, Sanjay, Yi, Tracey, Kirkpatrick, Robert, Dul, Edward, Jolivette, Larry, Marino, Jr, Joseph P, Willette, Robert, Lee, Dennis, Hu, Erding
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Discovery of 4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): A Potent, Selective, and Orally Active Transforming Growth Factor-β Type I Receptor Inhibitor
Gellibert, Françoise, de Gouville, Anne-Charlotte, Woolven, James, Mathews, Neil, Nguyen, Van-Loc, Bertho-Ruault, Cécile, Patikis, Angela, Grygielko, Eugene T, Laping, Nicholas J, Huet, Stéphane
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Estrogen-induced stromal cell-derived factor-1 (SDF-1/ Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor α in rat uterine cells and tissues
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Published in Steroids (01.11.2009)
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Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists
Thompson, Scott K., Washburn, David G., Frazee, James S., Madauss, Kevin P., Hoang, Tram H., Lapinski, Leahann, Grygielko, Eugene T., Glace, Lindsay E., Trizna, Walter, Williams, Shawn P., Duraiswami, Chaya, Bray, Jeffrey D., Laping, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Inhibition of ALK5 signaling induces physeal dysplasia in rats
Frazier, Kendall, Thomas, Roberta, Scicchitano, Marshall, Mirabile, Rosanna, Boyce, Rogely, Zimmerman, Dawn, Grygielko, Eugene, Nold, James, DeGouville, Anne-Charlotte, Huet, Stephane, Laping, Nicholas, Gellibert, Francoise
Published in Toxicologic pathology (01.02.2007)
Published in Toxicologic pathology (01.02.2007)
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2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]thieno[2,3- b]pyridine derivatives as selective progesterone receptor agonists
Wang, Yonghui, Duraiswami, Chaya, Madauss, Kevin P., Tran, Thuy B., Williams, Shawn P., Deng, Su-Jun, Graybill, Todd L., Hammond, Marlys, Jones, David G., Grygielko, Eugene T., Bray, Jeffrey D., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists
Hammond, Marlys, Patterson, Jaclyn R., Manns, Sharada, Hoang, Tram H., Washburn, David G., Trizna, Walter, Glace, Lindsay, Grygielko, Eugene T., Nagilla, Rakesh, Nord, Melanie, Fries, Harvey E., Minick, Douglas J., Laping, Nicholas J., Bray, Jeffrey D., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
Published in Bioorganic & medicinal chemistry letters (15.05.2009)
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Improving the developability profile of pyrrolidine progesterone receptor partial agonists
Kallander, Lara S., Washburn, David G., Hoang, Tram H., Frazee, James S., Stoy, Patrick, Johnson, Latisha, Lu, Qing, Hammond, Marlys, Barton, Linda S., Patterson, Jaclyn R., Azzarano, Leonard M., Nagilla, Rakesh, Madauss, Kevin P., Williams, Shawn P., Stewart, Eugene L., Duraiswami, Chaya, Grygielko, Eugene T., Xu, Xiaoping, Laping, Nicholas J., Bray, Jeffrey D., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
Published in Bioorganic & medicinal chemistry letters (01.01.2010)
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Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists
Washburn, David G., Hoang, Tram H., Frazee, James S., Johnson, Latisha, Hammond, Marlys, Manns, Sharada, Madauss, Kevin P., Williams, Shawn P., Duraiswami, Chaya, Tran, Thuy B., Stewart, Eugene L., Grygielko, Eugene T., Glace, Lindsay E., Trizna, Walter, Nagilla, Rakesh, Bray, Jeffrey D., Thompson, Scott K.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Osmolality: a physiological long-term regulator of lumbar sympathetic nerve activity and arterial pressure
Scrogin, Karie E, Grygielko, Eugene T, Brooks, Virginia L
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.06.1999)
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01.06.1999)
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The Angiotensin Type 1 Receptor Antagonist, Eprosartan, Attenuates the Progression of Renal Disease in Spontaneously Hypertensive Stroke-Prone Rats with Accelerated Hypertension
Abrahamsen, Christian T, Barone, Frank C, Campbell, Jr, Wallace G, Nelson, Allen H, Contino, Lisa C, Pullen, Mark A, Grygielko, Eugene T, Edwards, Richard M, Laping, Nicholas J, Brooks, David P
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2002)
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Effects of Angiotensins II and IV on Blood Pressure, Renal Function, and PAI-1 Expression in the Heart and Kidney of the Rat
Abrahamsen, Christian T., Pullen, Mark A., Schnackenberg, Christine G., Grygielko, Eugene T., Edwards, Richard M., Laping, Nicholas J., Brooks, David P.
Published in Pharmacology (01.09.2002)
Published in Pharmacology (01.09.2002)
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Role of caspases in human renal proximal tubular epithelial cell apoptosis
Wong, Victoria Y, Keller, Paul M, Nuttall, Mark E, Kikly, Kristine, DeWolf, Walter E, Lee, Dennis, Ali, Shujath M, Nadeau, Daniel P, Grygielko, Eugene T, Laping, Nicholas J, Brooks, David P
Published in European journal of pharmacology (21.12.2001)
Published in European journal of pharmacology (21.12.2001)
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The role of transforming growth factor-β and its receptors in human prostate smooth muscle cell fibronectin production
Butter, Sebastian, Laping, Nicholas J, Pullen, Mark, Grygielko, Eugene, Olson, Barbara, Brooks, David P
Published in European journal of pharmacology (22.06.2001)
Published in European journal of pharmacology (22.06.2001)
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