Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment Approach
Bareche, Yacine, Buisseret, Laurence, Gruosso, Tina, Girard, Edwina, Venet, David, Dupont, Floriane, Desmedt, Christine, Larsimont, Denis, Park, Morag, Rothé, Françoise, Stagg, John, Sotiriou, Christos
Published in JNCI : Journal of the National Cancer Institute (01.07.2020)
Published in JNCI : Journal of the National Cancer Institute (01.07.2020)
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Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers
Gruosso, Tina, Gigoux, Mathieu, Manem, Venkata Satya Kumar, Bertos, Nicholas, Zuo, Dongmei, Perlitch, Irina, Saleh, Sadiq Mehdi Ismail, Zhao, Hong, Souleimanova, Margarita, Johnson, Radia Marie, Monette, Anne, Ramos, Valentina Muñoz, Hallett, Michael Trevor, Stagg, John, Lapointe, Réjean, Omeroglu, Atilla, Meterissian, Sarkis, Buisseret, Laurence, Van den Eynden, Gert, Salgado, Roberto, Guiot, Marie-Christine, Haibe-Kains, Benjamin, Park, Morag
Published in The Journal of clinical investigation (01.04.2019)
Published in The Journal of clinical investigation (01.04.2019)
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Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression
Maller, Ori, Drain, Allison P., Barrett, Alexander S., Borgquist, Signe, Ruffell, Brian, Zakharevich, Igor, Pham, Thanh T., Gruosso, Tina, Kuasne, Hellen, Lakins, Johnathon N., Acerbi, Irene, Barnes, J. Matthew, Nemkov, Travis, Chauhan, Aastha, Gruenberg, Jessica, Nasir, Aqsa, Bjarnadottir, Olof, Werb, Zena, Kabos, Peter, Chen, Yunn-Yi, Hwang, E. Shelley, Park, Morag, Coussens, Lisa M., Nelson, Andrew C., Hansen, Kirk C., Weaver, Valerie M.
Published in Nature materials (01.04.2021)
Published in Nature materials (01.04.2021)
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miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
Mateescu, Bogdan, Batista, Luciana, Cardon, Melissa, Gruosso, Tina, de Feraudy, Yvan, Mariani, Odette, Nicolas, André, Meyniel, Jean-Philippe, Cottu, Paul, Sastre-Garau, Xavier, Mechta-Grigoriou, Fatima
Published in Nature medicine (01.12.2011)
Published in Nature medicine (01.12.2011)
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Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients
Gruosso, Tina, Mieulet, Virginie, Cardon, Melissa, Bourachot, Brigitte, Kieffer, Yann, Devun, Flavien, Dubois, Thierry, Dutreix, Marie, Vincent‐Salomon, Anne, Miller, Kyle Malcolm, Mechta‐Grigoriou, Fatima
Published in EMBO molecular medicine (01.05.2016)
Published in EMBO molecular medicine (01.05.2016)
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HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin
Biondini, Marco, Kiepas, Alex, El-Houjeiri, Leeanna, Annis, Matthew G., Hsu, Brian E., Fortier, Anne-Marie, Morin, Geneviève, Martina, José A., Sirois, Isabelle, Aguilar-Mahecha, Adriana, Gruosso, Tina, McGuirk, Shawn, Rose, April A. N., Tokat, Unal M., Johnson, Radia M., Sahin, Ozgur, Bareke, Eric, St-Pierre, Julie, Park, Morag, Basik, Mark, Majewski, Jacek, Puertollano, Rosa, Pause, Arnim, Huang, Sidong, Keler, Tibor, Siegel, Peter M.
Published in Oncogene (18.03.2022)
Published in Oncogene (18.03.2022)
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Identification of Interacting Stromal Axes in Triple-Negative Breast Cancer
Saleh, Sadiq M I, Bertos, Nicholas, Gruosso, Tina, Gigoux, Mathieu, Souleimanova, Margarita, Zhao, Hong, Omeroglu, Atilla, Hallett, Michael T, Park, Morag
Published in Cancer research (Chicago, Ill.) (01.09.2017)
Published in Cancer research (Chicago, Ill.) (01.09.2017)
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CrosstalkNet: A Visualization Tool for Differential Co-expression Networks and Communities
Manem, Venkata, Adam, George Alexandru, Gruosso, Tina, Gigoux, Mathieu, Bertos, Nicholas, Park, Morag, Haibe-Kains, Benjamin
Published in Cancer research (Chicago, Ill.) (15.04.2018)
Published in Cancer research (Chicago, Ill.) (15.04.2018)
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Predicting Relapse in Patients With Triple Negative Breast Cancer (TNBC) Using a Deep-Learning Approach
Yu, Guangyuan, Li, Xuefei, He, Ting-Fang, Gruosso, Tina, Zuo, Dongmei, Souleimanova, Margarita, Ramos, Valentina Muñoz, Omeroglu, Atilla, Meterissian, Sarkis, Guiot, Marie-Christine, Yang, Li, Yuan, Yuan, Park, Morag, Lee, Peter P., Levine, Herbert
Published in Frontiers in physiology (23.09.2020)
Published in Frontiers in physiology (23.09.2020)
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KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer
Knight, Jennifer F., Sung, Vanessa Y.C., Kuzmin, Elena, Couzens, Amber L., de Verteuil, Danielle A., Ratcliffe, Colin D.H., Coelho, Paula P., Johnson, Radia M., Samavarchi-Tehrani, Payman, Gruosso, Tina, Smith, Harvey W., Lee, Wontae, Saleh, Sadiq M., Zuo, Dongmei, Zhao, Hong, Guiot, Marie-Christine, Davis, Ryan R., Gregg, Jeffrey P., Moraes, Christopher, Gingras, Anne-Claude, Park, Morag
Published in Cell reports (Cambridge) (20.03.2018)
Published in Cell reports (Cambridge) (20.03.2018)
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Infiltration of CD8⁺ T cells into tumor cell clusters in triple-negative breast cancer
Li, Xuefei, Gruosso, Tina, Zuo, Dongmei, Omeroglu, Atilla, Meterissian, Sarkis, Guiot, Marie-Christine, Salazar, Adam, Park, Morag, Levine, Herbert
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2019)
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Abstract 6710: AVID200, a first-in-class selective TGF-beta 1 and -beta 3 inhibitor, sensitizes tumors to immune checkpoint blockade therapies
Tremblay, Gilles, Gruosso, Tina, Denis, Jean-François, Figueredo, Rene, Koropatnick, Jim, O'Connor-McCourt, Maureen
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas
Gruosso, Tina, Garnier, Camille, Abelanet, Sophie, Kieffer, Yann, Lemesre, Vincent, Bellanger, Dorine, Bieche, Ivan, Marangoni, Elisabetta, Sastre-Garau, Xavier, Mieulet, Virginie, Mechta-Grigoriou, Fatima
Published in Nature communications (12.10.2015)
Published in Nature communications (12.10.2015)
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Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
Murali, Bhavna, Ren, Qihao, Luo, Xianmin, Faget, Douglas V, Wang, Chun, Johnson, Radia Marie, Gruosso, Tina, Flanagan, Kevin C, Fu, Yujie, Leahy, Kathleen, Alspach, Elise, Su, Xinming, Ross, Michael H, Burnette, Barry, Weilbaecher, Katherine N, Park, Morag, Mbalaviele, Gabriel, Monahan, Joseph B, Stewart, Sheila A
Published in Cancer research (Chicago, Ill.) (01.10.2018)
Published in Cancer research (Chicago, Ill.) (01.10.2018)
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Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
Kos, Zuzana, Roblin, Elvire, Kim, Rim S., Michiels, Stefan, Gallas, Brandon D., Chen, Weijie, van de Vijver, Koen K., Goel, Shom, Adams, Sylvia, Demaria, Sandra, Viale, Giuseppe, Nielsen, Torsten O., Badve, Sunil S., Symmans, W. Fraser, Sotiriou, Christos, Rimm, David L., Hewitt, Stephen, Denkert, Carsten, Loibl, Sibylle, Luen, Stephen J., Bartlett, John M. S., Savas, Peter, Pruneri, Giancarlo, Dillon, Deborah A., Cheang, Maggie Chon U., Tutt, Andrew, Hall, Jacqueline A., Kok, Marleen, Horlings, Hugo M., Madabhushi, Anant, van der Laak, Jeroen, Ciompi, Francesco, Laenkholm, Anne-Vibeke, Bellolio, Enrique, Gruosso, Tina, Fox, Stephen B., Araya, Juan Carlos, Floris, Giuseppe, Hudeček, Jan, Voorwerk, Leonie, Beck, Andrew H., Kerner, Jen, Larsimont, Denis, Declercq, Sabine, Van den Eynden, Gert, Pusztai, Lajos, Ehinger, Anna, Yang, Wentao, AbdulJabbar, Khalid, Yuan, Yinyin, Singh, Rajendra, Hiley, Crispin, Bakir, Maise al, Lazar, Alexander J., Naber, Stephen, Wienert, Stephan, Castillo, Miluska, Curigliano, Giuseppe, Dieci, Maria-Vittoria, André, Fabrice, Swanton, Charles, Reis-Filho, Jorge, Sparano, Joseph, Balslev, Eva, Chen, I-Chun, Stovgaard, Elisabeth Ida Specht, Pogue-Geile, Katherine, Blenman, Kim R. M., Penault-Llorca, Frédérique, Schnitt, Stuart, Lakhani, Sunil R., Vincent-Salomon, Anne, Rojo, Federico, Braybrooke, Jeremy P., Hanna, Matthew G., Soler-Monsó, M. Teresa, Bethmann, Daniel, Castaneda, Carlos A., Willard-Gallo, Karen, Sharma, Ashish, Lien, Huang-Chun, Fineberg, Susan, Thagaard, Jeppe, Comerma, Laura, Gonzalez-Ericsson, Paula, Brogi, Edi, Loi, Sherene, Saltz, Joel, Klaushen, Frederick, Cooper, Lee, Amgad, Mohamed, Moore, David A., Salgado, Roberto
Published in NPJ breast cancer (12.05.2020)
Published in NPJ breast cancer (12.05.2020)
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Abstract PO-080: Predicting relapse in patients with triple negative breast cancer (TNBC) using a deep-learning approach
Yu, Guangyuan, Li, Xuefei, He, Ting-Fang, Gruosso, Tina, Zuo, Dongmei, Souleimanova, Margarita, Ramos, Valentina Muñoz, Omeroglu, Atilla, Meterissian, Sarkis, Guiot, Marie-Christine, Yang, Li, Yuan, Yuan, Park, Morag, Lee, Peter P., Levine, Herbert
Published in Cancer research (Chicago, Ill.) (01.11.2020)
Published in Cancer research (Chicago, Ill.) (01.11.2020)
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AVID200, first-in-class TGF-beta 1 and 3 selective and potent inhibitor: Safety and biomarker results of a phase I monotherapy dose-escalation study in patients with advanced solid tumors
Yap, Timothy A, Lakhani, Nehal J., Araujo, Daniel Vilarim, Rodon Ahnert, Jordi, Chandana, Sreenivasa R, Sharma, Manish, Denis, Jean-François, Gruosso, Tina, Tremblay, Gilles, O'Connor, Maureen, Ghosh, Ria, Sinclair, Sandra, Wood, Debra L., Nadler, Paul I., Siu, Lillian L.
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer
Mohammad, Amro H, Kim, Sung-Hoon, Bertos, Nicholas, El-Assaad, Wissal, Nandi, Ipshita, Smith, Harvey, Yang, Jieyi, Chen, Owen J, Gamache, Isabelle, Rao, Trisha, Gagnon, Bruno, Gruosso, Tina, Tremblay, Michel L, Sonenberg, Nahum, Guiot, Marie-Christine, Muller, William, Park, Morag, Teodoro, Jose G
Published in Molecular cancer research (01.10.2020)
Published in Molecular cancer research (01.10.2020)
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Journal Article
Abstract IA23: Deconvolution of the triple-negative breast cancer microenvironment
Saleh, Sadiq, Gruosso, Tina, Gigoux, Mathieu, Bertos, Nicholas, Omeroglu, Atilla, Zuo, Dongmei, Meterissian, Sarkis, Hallett, Michael, Park, Morag
Published in Cancer research (Chicago, Ill.) (01.08.2016)
Published in Cancer research (Chicago, Ill.) (01.08.2016)
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Journal Article
Abstract 720: Novel prognostic stromal subtypes in triple-negative breast cancer
Thompson, Crista, Saleh, Sadiq M., Bertos, Nicholas, Gigoux, Mathieu, Gruosso, Tina, Souleimanova, Margarita, Zhao, Hong, Hallett, Michael T., Park, Morag
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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