Search Results - "Grundy, John S." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates

Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates

by Rigo, Frank, Chun, Seung J, Norris, Daniel A, Hung, Gene, Lee, Sam, Matson, John, Fey, Robert A, Gaus, Hans, Hua, Yimin, Grundy, John S, Krainer, Adrian R, Henry, Scott P, Bennett, C Frank
Published in The Journal of pharmacology and experimental therapeutics (01.07.2014)

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Clinical pharmacokinetics of second generation antisense oligonucleotides

Clinical pharmacokinetics of second generation antisense oligonucleotides

by Yu, Rosie Z, Grundy, John S, Geary, Richard S
Published in Expert opinion on drug metabolism & toxicology (01.02.2013)

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Predictive Dose-Based Estimation of Systemic Exposure Multiples in Mouse and Monkey Relative to Human for Antisense Oligonucleotides With 2′-O-(2-Methoxyethyl) Modifications

Predictive Dose-Based Estimation of Systemic Exposure Multiples in Mouse and Monkey Relative to Human for Antisense Oligonucleotides With 2′-O-(2-Methoxyethyl) Modifications

by Yu, Rosie Z, Grundy, John S, Henry, Scott P, Kim, Tae-Won, Norris, Daniel A, Burkey, Jennifer, Wang, Yanfeng, Vick, Andrew, Geary, Richard S
Published in Molecular therapy. Nucleic acids (01.01.2015)

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Safety, tolerability, and pharmacokinetics of the selective prostacyclin receptor agonist ralinepag in single and multiple dosing studies of an immediate-release oral formulation in healthy volunteers

Safety, tolerability, and pharmacokinetics of the selective prostacyclin receptor agonist ralinepag in single and multiple dosing studies of an immediate-release oral formulation in healthy volunteers

by Grundy, John S., King, Christopher D., Adams, John W., Cabell, Christopher H.
Published in Pulmonary circulation (01.04.2020)

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S759 Model-Predicted Lymphocyte Response and Recovery Profiles for the Sphingosine 1-Phosphate Receptor Modulators Ozanimod and Etrasimod

S759 Model-Predicted Lymphocyte Response and Recovery Profiles for the Sphingosine 1-Phosphate Receptor Modulators Ozanimod and Etrasimod

by Lee, Caroline A., Waterhouse, Timothy, Heathman, Michael, Oh, D. Alex, Komori, H. Kiyomi, Grundy, John S.
Published in The American journal of gastroenterology (01.10.2022)

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S774 Pharmacokinetics, Safety, and Tolerability of Etrasimod: Results From a Phase 1 Drug-Drug Interaction Study in Healthy Volunteers

S774 Pharmacokinetics, Safety, and Tolerability of Etrasimod: Results From a Phase 1 Drug-Drug Interaction Study in Healthy Volunteers

by Lee, Caroline A., Tang, Yong, Villa-Caballero, Leonel, Shan, Kevin, Randle, Andrenika, Grundy, John S.
Published in The American journal of gastroenterology (01.10.2022)

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S959 A Phase 1 Drug Interaction Study Evaluating the Effects of Itraconazole on the Pharmacokinetics, Safety, and Tolerability of Etrasimod in Healthy Volunteers

S959 A Phase 1 Drug Interaction Study Evaluating the Effects of Itraconazole on the Pharmacokinetics, Safety, and Tolerability of Etrasimod in Healthy Volunteers

by Lee, Caroline A., Ramaiya, Atulkumar, Tang, Yong, Sapone, Anna, Gilder, Kye, Randle, Andrenika, Grundy, John S.
Published in The American journal of gastroenterology (01.10.2022)

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S720 Pharmacokinetics (PK), Safety, and Tolerability of Etrasimod (APD334) in Participants With Mild, Moderate, or Severe Hepatic Impairment: A Single-Dose, Open-Label, Parallel-Group Study

S720 Pharmacokinetics (PK), Safety, and Tolerability of Etrasimod (APD334) in Participants With Mild, Moderate, or Severe Hepatic Impairment: A Single-Dose, Open-Label, Parallel-Group Study

by Lee, Caroline, Tang, Yong, Schroeder, Cassandra, Zhang, Jinkun, Nguyen-Cleary, Thai, Ma, Michael, Lyon, Naomi, Grundy, John S.
Published in The American journal of gastroenterology (01.10.2021)

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Cardiovascular Evaluation of Etrasimod, a Selective Sphingosine 1-phosphate Receptor Modulator, in Healthy Adults: Results of a Randomized, Thorough QT/QTc Study

Cardiovascular Evaluation of Etrasimod, a Selective Sphingosine 1-phosphate Receptor Modulator, in Healthy Adults: Results of a Randomized, Thorough QT/QTc Study

by Darpo, Borje, Connor, Kalvin, Cabell, Christopher H, Grundy, John S
Published in Clinical pharmacology in drug development (01.04.2024)

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Safety, Pharmacokinetics, and Pharmacodynamics of Etrasimod: Single and Multiple Ascending Dose Studies in Healthy Adults

Safety, Pharmacokinetics, and Pharmacodynamics of Etrasimod: Single and Multiple Ascending Dose Studies in Healthy Adults

by Lee, Caroline A., Schreiber, Stefan, Bressler, Brian, Adams, John W., Oh, Dooman Alexander, Tang, Yong Q., Zhang, Jinkun, Komori, Heather Kiyomi, Grundy, John S.
Published in Clinical pharmacology in drug development (01.05.2024)

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Disposition and Mass Balance of Etrasimod in Healthy Subjects and In Vitro Determination of the Enzymes Responsible for Its Oxidative Metabolism

Disposition and Mass Balance of Etrasimod in Healthy Subjects and In Vitro Determination of the Enzymes Responsible for Its Oxidative Metabolism

by Lee, Caroline A., Oh, D. Alexander, Tang, Yong, Yi, Ping, Bashir, Mohammad, English, Stephen, Croft, Marie, Blackburn, Anthony, Bloom, Steve, Gilder, Kye, Grundy, John S.
Published in Clinical pharmacology in drug development (01.06.2023)

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Lack of clinical pharmacodynamic and pharmacokinetic drug-drug interactions between warfarin and the antisense oligonucleotide mipomersen

Lack of clinical pharmacodynamic and pharmacokinetic drug-drug interactions between warfarin and the antisense oligonucleotide mipomersen

by Li, Zhaoyang, Hard, Marjie L, Grundy, John S, Singh, Tejdip, von Moltke, Lisa L, Boltje, Ingrid
Published in Journal of cardiovascular pharmacology (01.08.2014)

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No effect on QT intervals of mipomersen, a 2′-O-methoxyethyl modified antisense oligonucleotide targeting ApoB-100 mRNA, in a phase I dose escalation placebo-controlled study, and confirmed by a thorough QT (tQT) study, in healthy subjects

No effect on QT intervals of mipomersen, a 2′-O-methoxyethyl modified antisense oligonucleotide targeting ApoB-100 mRNA, in a phase I dose escalation placebo-controlled study, and confirmed by a thorough QT (tQT) study, in healthy subjects

by Yu, Rosie Z., Gunawan, Rudy, Li, Zhaoyang, Mittleman, Robert S., Mahmood, Asif, Grundy, John S., Singleton, Walter, Geary, Richard, Wang, Yanfeng
Published in European journal of clinical pharmacology (01.03.2016)

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Changes in Mipomersen Dosing Regimen Provide Similar Exposure With Improved Tolerability in Randomized Placebo‐Controlled Study of Healthy Volunteers

Changes in Mipomersen Dosing Regimen Provide Similar Exposure With Improved Tolerability in Randomized Placebo‐Controlled Study of Healthy Volunteers

by Flaim, JoAnn D., Grundy, John S., Baker, Brenda F., McGowan, Mary P., Kastelein, John J. P.
Published in Journal of the American Heart Association (01.04.2014)

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Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. II. Improved in vitro-in vivo correlation using a two-phase dissolution test

Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. II. Improved in vitro-in vivo correlation using a two-phase dissolution test

by Grundy, John S, Anderson, Keith E, Rogers, James A, Foster, Robert T
Published in Journal of controlled release (01.09.1997)

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Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas

Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas

by Grossman, Stuart A, Alavi, Jane B, Supko, Jeffrey G, Carson, Kathryn A, Priet, Regina, Dorr, F Andrew, Grundy, John S, Holmlund, Jon T
Published in Neuro-oncology (Charlottesville, Va.) (01.01.2005)

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Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy

Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy

by RAGUENEAU-MAJLESSI, Isabelle, LEVY, Rene H, BRODIE, Martin, SMITH, David, SHAH, Jaymin, GRUNDY, John S
Published in Clinical pharmacokinetics (01.01.2005)

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Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients

Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients

by Ragueneau-Majlessi, Isabelle, Levy, Rene H., Bergen, Donna, Garnett, William, Rosenfeld, William, Mather, Gary, Shah, Jaymin, Grundy, John S.
Published in Epilepsy research (01.11.2004)

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P207 Effects of fluconazole, gemfibrozil, and rifampin on the pharmacokinetics, safety, and tolerability of etrasimod

P207 Effects of fluconazole, gemfibrozil, and rifampin on the pharmacokinetics, safety, and tolerability of etrasimod

by Lee, Caroline, Taylor, Carly, Tang, Yong, Villa-Caballero, Leonel, Shan, Kevin, Randle, Andrenika, Grundy, John S
Published in Gut (19.06.2022)

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Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. I. Description of a two-phase in vitro dissolution test

Studies on dissolution testing of the nifedipine gastrointestinal therapeutic system. I. Description of a two-phase in vitro dissolution test

by Grundy, John S, Anderson, Keith E, Rogers, James A, Foster, Robert T
Published in Journal of controlled release (22.09.1997)

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