FcγRIIIa chromatography to enrich a-fucosylated glycoforms and assess the potency of glycoengineered therapeutic antibodies
Freimoser–Grundschober, Anne, Rueger, Petra, Fingas, Felix, Sondermann, Peter, Herter, Sylvia, Schlothauer, Tilman, Umana, Pablo, Neumann, Christiane
Published in Journal of Chromatography A (11.01.2020)
Published in Journal of Chromatography A (11.01.2020)
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Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
Geiger, Martina, Stubenrauch, Kay-Gunnar, Sam, Johannes, Richter, Wolfgang F., Jordan, Gregor, Eckmann, Jan, Hage, Carina, Nicolini, Valeria, Freimoser-Grundschober, Anne, Ritter, Mirko, Lauer, Matthias E., Stahlberg, Henning, Ringler, Philippe, Patel, Jigar, Sullivan, Eric, Grau-Richards, Sandra, Endres, Stefan, Kobold, Sebastian, Umaña, Pablo, Brünker, Peter, Klein, Christian
Published in Nature communications (24.06.2020)
Published in Nature communications (24.06.2020)
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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane
Published in eLife (11.08.2021)
Published in eLife (11.08.2021)
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Journal Article
Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
Waldhauer, Inja, Gonzalez-Nicolini, Valeria, Freimoser-Grundschober, Anne, Nayak, Tapan K, Fahrni, Linda, Hosse, Ralf J, Gerrits, Danny, Geven, Edwin J W, Sam, Johannes, Lang, Sabine, Bommer, Esther, Steinhart, Virginie, Husar, Elisabeth, Colombetti, Sara, Van Puijenbroek, Erwin, Neubauer, Markus, Cline, J Mark, Garg, Pradeep K, Dugan, Gregory, Cavallo, Federica, Acuna, Gonzalo, Charo, Jehad, Teichgräber, Volker, Evers, Stefan, Boerman, Otto C, Bacac, Marina, Moessner, Ekkehard, Umaña, Pablo, Klein, Christian
Published in mAbs (01.01.2021)
Published in mAbs (01.01.2021)
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Characterization of anti-drug antibody responses to the T-cell engaging bispecific antibody cibisatamab to understand the impact on exposure
Lotz, Gregor P, Lutz, Achim, Martin-Facklam, Meret, Hansbauer, Andre, Schick, Eginhard, Moessner, Ekkehard, Antony, Michael, Stuchly, Thomas, Viert, Maria, Hosse, Ralf J, Freimoser-Grundschober, Anne, Klein, Christian, Schäfer, Martin, Ritter, Mirko, Stubenrauch, Kay-Gunnar
Published in Frontiers in immunology (31.05.2024)
Published in Frontiers in immunology (31.05.2024)
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Journal Article
JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy
Leclercq, Gabrielle, Haegel, Hélène, Toso, Alberto, Zimmermann, Tina, Green, Luke, Steinhoff, Nathalie, Sam, Johannes, Pulko, Vesna, Schneider, Anneliese, Giusti, Anna Maria, Challier, John, Freimoser-Grundschober, Anne, Larivière, Laurent, Odermatt, Alex, Stern, Martin, Umana, Pablo, Bacac, Marina, Klein, Christian
Published in Journal for immunotherapy of cancer (01.01.2022)
Published in Journal for immunotherapy of cancer (01.01.2022)
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Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors
Stock, Sophia, Benmebarek, Mohamed-Reda, Kluever, Anna-Kristina, Darowski, Diana, Jost, Christian, Stubenrauch, Kay-Gunnar, Benz, Joerg, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Umana, Pablo, Subklewe, Marion, Endres, Stefan, Klein, Christian, Kobold, Sebastian
Published in Journal for immunotherapy of cancer (01.07.2022)
Published in Journal for immunotherapy of cancer (01.07.2022)
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Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo
Published in Oncoimmunology (04.03.2017)
Published in Oncoimmunology (04.03.2017)
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Novel Tumor-Targeted, Engineered IL-2 Variant (IL2v)-Based Immunocytokines For Immunotherapy Of Cancer
Klein, Christian, Waldhauer, Inja, Nicolini, Valeria, Dunn, Claire, Freimoser-Grundschober, Anne, Danny, Gerrits, Boerman, Otto, Nayak, Tapan, Herter, Sylvia, Van Puijenbroek, Erwin, Ast, Oliver, Hofer, Thomas, Hosse, Ralf, Lang, Sabine, Neumann, Sebastian, Kettenberger, Hubert, Neubauer, Markus, Gorr, Ingo, Tuerck, Dietrich, Evers, Stefan, Gerdes, Christian, Levitsky, Victor, Bacac, Marina, Moessner, Ekkehard, Umana, Pablo
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies
Bacac, Marina, Colombetti, Sara, Herter, Sylvia, Sam, Johannes, Perro, Mario, Chen, Stanford, Bianchi, Roberta, Richard, Marine, Schoenle, Anne, Nicolini, Valeria, Diggelmann, Sarah, Limani, Florian, Schlenker, Ramona, Hüsser, Tamara, Richter, Wolfgang, Bray-French, Katharine, Hinton, Heather, Giusti, Anna Maria, Freimoser-Grundschober, Anne, Lariviere, Laurent, Neumann, Christiane, Klein, Christian, Umaña, Pablo
Published in Clinical cancer research (01.10.2018)
Published in Clinical cancer research (01.10.2018)
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Journal Article
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells
Codarri Deak, Laura, Nicolini, Valeria, Hashimoto, Masao, Karagianni, Maria, Schwalie, Petra C., Lauener, Laura, Varypataki, Eleni Maria, Richard, Marine, Bommer, Esther, Sam, Johannes, Joller, Stefanie, Perro, Mario, Cremasco, Floriana, Kunz, Leo, Yanguez, Emilio, Hüsser, Tamara, Schlenker, Ramona, Mariani, Marisa, Tosevski, Vinko, Herter, Sylvia, Bacac, Marina, Waldhauer, Inja, Colombetti, Sara, Gueripel, Xavier, Wullschleger, Stephan, Tichet, Melanie, Hanahan, Douglas, Kissick, Haydn T., Leclair, Stephane, Freimoser-Grundschober, Anne, Seeber, Stefan, Teichgräber, Volker, Ahmed, Rafi, Klein, Christian, Umaña, Pablo
Published in Nature (London) (06.10.2022)
Published in Nature (London) (06.10.2022)
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A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease
Peterson, Laurence B., Bell, Charles J.M., Howlett, Sarah K., Pekalski, Marcin L., Brady, Kevin, Hinton, Heather, Sauter, Denise, Todd, John A., Umana, Pablo, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Klein, Christian, Hosse, Ralf J., Wicker, Linda S.
Published in Journal of autoimmunity (01.12.2018)
Published in Journal of autoimmunity (01.12.2018)
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Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
Claus, Christina, Ferrara, Claudia, Xu, Wei, Sam, Johannes, Lang, Sabine, Uhlenbrock, Franziska, Albrecht, Rosmarie, Herter, Sylvia, Schlenker, Ramona, Hüsser, Tamara, Diggelmann, Sarah, Challier, John, Mössner, Ekkehard, Hosse, Ralf J, Hofer, Thomas, Brünker, Peter, Joseph, Catherine, Benz, Jörg, Ringler, Philippe, Stahlberg, Henning, Lauer, Matthias, Perro, Mario, Chen, Stanford, Küttel, Christine, Bhavani Mohan, Preethi L, Nicolini, Valeria, Birk, Martina Carola, Ongaro, Amandine, Prince, Christophe, Gianotti, Reto, Dugan, Gregory, Whitlow, Christopher T, Solingapuram Sai, Kiran Kumar, Caudell, David L, Burgos-Rodriguez, Armando G, Cline, J Mark, Hettich, Michael, Ceppi, Maurizio, Giusti, Anna Maria, Crameri, Flavio, Driessen, Wouter, Morcos, Peter N, Freimoser-Grundschober, Anne, Levitsky, Victor, Amann, Maria, Grau-Richards, Sandra, von Hirschheydt, Thomas, Tournaviti, Stella, Mølhøj, Michael, Fauti, Tanja, Heinzelmann-Schwarz, Viola, Teichgräber, Volker, Colombetti, Sara, Bacac, Marina, Zippelius, Alfred, Klein, Christian, Umaña, Pablo
Published in Science translational medicine (12.06.2019)
Published in Science translational medicine (12.06.2019)
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In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing
Lehmann, Steffi, Perera, Ramanil, Grimm, Hans-Peter, Sam, Johannes, Colombetti, Sara, Fauti, Tanja, Fahrni, Linda, Schaller, Teilo, Freimoser-Grundschober, Anne, Zielonka, Jörg, Stoma, Szymon, Rudin, Markus, Klein, Christian, Umana, Pablo, Gerdes, Christian, Bacac, Marina
Published in Clinical cancer research (01.09.2016)
Published in Clinical cancer research (01.09.2016)
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Journal Article
이종이량체 Fc 도메인 항체
KLEIN CHRISTIAN, DAROWSKI DIANA, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 20.03.2024
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Year of Publication 20.03.2024
Patent
개선된 항원 결합 수용체
KLEIN CHRISTIAN, DAROWSKI DIANA, MOESSNER EKKEHARD, FREIMOSER GRUNDSCHOBER ANNE
Year of Publication 28.03.2023
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Year of Publication 28.03.2023
Patent
p95HER2-T cell bispecific antibody for breast cancer treatment
Rius Ruiz, Irene, Vicario, Rocio, Morancho, Beatriz, Morales, Cristina Bernadó, Arenas, Enrique J, Herter, Sylvia, Freimoser-Grundschober, Anne, Somandin, Jitka, Sam, Johannes, Ast, Oliver, Barriocanal, Águeda Martinez, Luque, Antonio, Escorihuela, Marta, Varela, Ismael, Cuartas, Isabel, Nuciforo, Paolo, Fasani, Roberta, Peg, Vicente, Rubio, Isabel, Cortés, Javier, Serra, Violeta, Escriva-de-Romani, Santiago, Sperinde, Jeff, Chenna, Ahmed, Huang, Weidong, Winslow, John, Albanell, Joan, Seoane, Joan, Scaltriti, Maurizio, Baselga, Jose, Tabernero, Josep, Umana, Pablo, Bacac, Marina, Saura, Cristina, Klein, Christian, Arribas, Joaquín
Published in Science translational medicine (03.10.2018)
Published in Science translational medicine (03.10.2018)
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Journal Article
Immuno-PET and Immuno-SPECT of Rheumatoid Arthritis with Radiolabeled Anti-Fibroblast Activation Protein Antibody Correlates with Severity of Arthritis
Laverman, Peter, van der Geest, Tessa, Terry, Samantha Y A, Gerrits, Danny, Walgreen, Birgitte, Helsen, Monique M, Nayak, Tapan K, Freimoser-Grundschober, Anne, Waldhauer, Inja, Hosse, Ralf J, Moessner, Ekkehard, Umana, Pablo, Klein, Christian, Oyen, Wim J G, Koenders, Marije I, Boerman, Otto C
Published in Journal of Nuclear Medicine (01.05.2015)
Published in Journal of Nuclear Medicine (01.05.2015)
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Journal Article
A Novel EGFRvIII T-Cell Bispecific Antibody for the Treatment of Glioblastoma
Iurlaro, Raffaella, Waldhauer, Inja, Planas-Rigol, Ester, Bonfill-Teixidor, Ester, Arias, Alexandra, Nicolini, Valeria, Freimoser-Grundschober, Anne, Cuartas, Isabel, Martínez-Moreno, Alba, Martínez-Ricarte, Francisco, Cordero, Esteban, Cicuendez, Marta, Casalino, Simona, Guardia-Reyes, Xavier, Fahrni, Linda, Pöschinger, Thomas, Steinhart, Virginie, Richard, Marine, Briner, Stefanie, Mueller, Joerg, Osl, Franz, Sam, Johannes, Colombetti, Sara, Bacac, Marina, Klein, Christian, Pineda, Estela, Reyes-Figueroa, Luis, Di Somma, Alberto, González, Josep, Nuciforo, Paolo, Carles, Joan, Vieito, Maria, Tabernero, Josep, Umaña, Pablo, Seoane, Joan
Published in Molecular cancer therapeutics (07.10.2022)
Published in Molecular cancer therapeutics (07.10.2022)
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