Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
Douillard, JY, Cunningham, D, Roth, AD, Navarro, M, James, RD, Karasek, P, Jandik, P, Iveson, T, Carmichael, J, Alakl, M, Gruia, G, Awad, L, Rougier, P
Published in The Lancet (British edition) (25.03.2000)
Published in The Lancet (British edition) (25.03.2000)
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Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery
Giacchetti, S., Itzhaki, M., Gruia, G., Adam, R., Zidani, R., Kunstlinger, F., Brienza, S., Alafaci, E., Bertheault-Cvitkovic, F., Jasmin, C., Reynes, M., Bismuth, H., Misset, J. L., Lévi, F
Published in Annals of oncology (01.06.1999)
Published in Annals of oncology (01.06.1999)
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Dose-finding study of docetaxel and doxorubicin in first-line treatment of patients with metastatic breast cancer
Misset, J.L., Dieras, V., Gruia, G., Bourgeois, H., Cvitkovic, E., Kalla, S., Bozec, L., Beuzeboc, P., Jasmin, C., Aussel, J.P., Riva, A., Azli, N., Pouillart, P.
Published in Annals of oncology (01.05.1999)
Published in Annals of oncology (01.05.1999)
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Optimisation of irinotecan dose in the treatment of patients with metastatic colorectal cancer after 5-FU failure: results from a multinational, randomised phase II study
Van Cutsem, E, Dirix, L, Van Laethem, J-L, Van Belle, S, Borner, M, Gonzalez Baron, M, Roth, A, Morant, R, Joosens, E, Gruia, G, Sibaud, D, Bleiberg, H
Published in British journal of cancer (28.03.2005)
Published in British journal of cancer (28.03.2005)
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A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer
SCHOEMAKER, N. E, KUPPENS, I. E. L. M, VOZNYI, E, NORUM, J, FENNELLY, D, TVEIT, K. M, GARIN, A, GRUIA, G, MOURIER, A, SIBAUD, D, LEFEBVRE, P, BEIJNEN, J. H, MOISEYENKO, V, SCHELLENS, J. H. M, TEN BOKKEL HUININK, W. W, GLIMELIUS, B, KJAER, M, STARKHAMMER, H, RICHEL, D. J, SMAALAND, R, BERTELSEN, K, POULSEN, J. P
Published in British journal of cancer (18.10.2004)
Published in British journal of cancer (18.10.2004)
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A phase II study of irinotecan alternated with five days bolus of 5-fluorouracil and leucovorin in first-line chemotherapy of metastatic colorectal cancer
Van Cutsem, E., Pozzo, C., Starkhammar, H., Dirix, L., Terzoli, E., Cognetti, F., Humblet, Y., Garufi, C., Filez, L., Gruia, G., Cote, C., Barone, C.
Published in Annals of oncology (01.11.1998)
Published in Annals of oncology (01.11.1998)
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Phase I study of irinotecan and raltitrexed in patients with advanced gastrointestinal tract adenocarcinoma
FORD, H. E. R, CUNNINGHAM, D, ROSS, P. J, RAO, S, AHERNE, G. W, BENEPAL, T. S, PRICE, T, MASSEY, A, VERNILLET, L, GRUIA, G
Published in British journal of cancer (01.07.2000)
Published in British journal of cancer (01.07.2000)
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Irinotecan Plus Gemcitabine Results in No Survival Advantage Compared With Gemcitabine Monotherapy in Patients With Locally Advanced or Metastatic Pancreatic Cancer Despite Increased Tumor Response Rate
ROCHA LIMA, Caio M, GREEN, Mark R, ROTCHE, Robert, MILLER, Wilson H, JEFFREY, G. Mark, CISAR, Laura A, MORGANTI, Adele, ORLANDO, Nicoletta, GRUIA, Gabriela, MILLER, Langdon L
Published in Journal of clinical oncology (15.09.2004)
Published in Journal of clinical oncology (15.09.2004)
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Treatment with a nonanthracycline regimen in advanced breast cancer: vinorelbine, cyclophosphamide, and 5-fluorouracil with folinic acid
Turpin, F, Lluch, A, Closon, M H, Gruia, G, Llombart, A, Fernandez, R, Delgado, F M, Biville, F
Published in American journal of clinical oncology (01.04.1999)
Published in American journal of clinical oncology (01.04.1999)
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Irinotecan Plus Fluorouracil/Leucovorin for Metastatic Colorectal Cancer: A New Survival Standard
Saltz, Leonard B., Douillard, Jean‐Yves, Pirotta, Nicoletta, Alakl, May, Gruia, Gabriela, Awad, Lucile, Elfring, Gary L., Locker, Paula K., Miller, Langdon L.
Published in The oncologist (Dayton, Ohio) (01.01.2001)
Published in The oncologist (Dayton, Ohio) (01.01.2001)
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Continuous administration of irinotecan by hepatic arterial infusion: A Phase I and pharmacokinetic study
VAN RIEL, Johanna M. G. H, VAN GROENINGEN, Cees J, KEDDE, Mark A, GALL, Helen, LEISINK, Johanna M. A, GRUIA, Gabriella, PINEDO, Herbert M, VAN DER VIJGH, Wim J. F, GIACCONE, Giuseppe
Published in Clinical cancer research (01.02.2002)
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Published in Clinical cancer research (01.02.2002)
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A case for time to tumor progression (TTP) as the primary (1 o ) efficacy endpoint in 1 st -line metastatic colorectal cancer (MCRC) therapy: Correlation of TTP and overall survival (OS)
Miller, L. L., Elfring, G. L., Gruia, G., Hirawat, S., Douillard, J. Y., Saltz, L. B.
Published in Journal of clinical oncology (15.07.2004)
Published in Journal of clinical oncology (15.07.2004)
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A case for time to tumor progression (TTP) as the primary (1 o ) efficacy endpoint in 1 st -line metastatic colorectal cancer (MCRC) therapy: Correlation of TTP and overall survival (OS)
Miller, L. L., Elfring, G. L., Gruia, G., Hirawat, S., Douillard, J. Y., Saltz, L. B.
Published in Journal of clinical oncology (15.07.2004)
Published in Journal of clinical oncology (15.07.2004)
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Phase I and Pharmacokinetic Study of Irinotecan Administered as a Low-Dose, Continuous Intravenous Infusion Over 14 Days in Patients With Malignant Solid Tumors
HERBEN, V. M. M, SCHELLENS, J. H. M, SWART, M, GRUIA, G, VERNILLET, L, BEIJNEN, J. H, TEN BOKKEL HUININK, W. W
Published in Journal of clinical oncology (01.06.1999)
Published in Journal of clinical oncology (01.06.1999)
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Phase I dose finding study of irinotecan hydrochloride trihydrate (CPT11) with tomudex (TX.) in patients with 5-FU refractory colorectal cancer
Cunningham, D., Ross, P., Webb, A., Allen, M., Massey, A., Cote, C., Gruia, G.
Published in European journal of cancer (1990) (01.09.1997)
Published in European journal of cancer (1990) (01.09.1997)
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A randomized phase II trial assessing irinotecan (IRI) and 5FU/folinic acid (LV), “Mayo regimen”, in first line palliative chemotherapy patients (pts) with metastatic colorectal cancer (MCRC)
Pozzo, C., Pyrhönen, S., Bodrogi, I., Szanto, J., Kamica-Mlodkowska, H., Starkammar, H., Izso, J., Hansen, P., Kjaer, M., Noël, N., Gruia, G., Barone, C.
Published in European journal of cancer (1990) (01.09.1999)
Published in European journal of cancer (1990) (01.09.1999)
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Irinotecan (Iri) in combination with high-dose infusional (HDI) 5FU/FA either weekly or bi-weekly: evidence of survival advantage and quality of life (QoL) improvement in metastatic colorectal cancer (MCRC)
Rougier, P., Cunningham, D., Roth, A.D., Germa, J.R., James, R.D., Karasek, P., Jandik, P., Iveson, T., Carmichael, J., Gruia, G., Alakl, M., Sibaud, D., Douillard, J.Y.
Published in European journal of cancer (1990) (01.09.1999)
Published in European journal of cancer (1990) (01.09.1999)
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