Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma
Cloughesy, Timothy F, Landolfi, Joseph, Hogan, Daniel J, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Elder, J Bradley, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh Leia, Piccioni, David, Walbert, Tobias, Chu, Alice, Das, Asha, Diago, Oscar R, Gammon, Dawn, Gruber, Harry E, Hanna, Michelle, Jolly, Douglas J, Kasahara, Noriyuki, McCarthy, David, Mitchell, Leah, Ostertag, Derek, Robbins, Joan M, Rodriguez-Aguirre, Maria, Vogelbaum, Michael A
Published in Science translational medicine (01.06.2016)
Published in Science translational medicine (01.06.2016)
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A short discussion about the SARS-CoV-2 mRNA-1273 vaccine
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Published in International journal of infectious diseases (01.03.2021)
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Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity
Hiraoka, Kei, Inagaki, Akihito, Kato, Yuki, Huang, Tiffany T, Mitchell, Leah A, Kamijima, Shuichi, Takahashi, Masamichi, Matsumoto, Hiroshi, Hacke, Katrin, Kruse, Carol A, Ostertag, Derek, Robbins, Joan M, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
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Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model
Huang, Tiffany T, Parab, Shraddha, Burnett, Ryan, Diago, Oscar, Ostertag, Derek, Hofman, Florence M, Espinoza, Fernando Lopez, Martin, Bryan, Ibañez, Carlos E, Kasahara, Noriyuki, Gruber, Harry E, Pertschuk, Daniel, Jolly, Douglas J, Robbins, Joan M
Published in Human gene therapy (01.02.2015)
Published in Human gene therapy (01.02.2015)
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Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer
Inoko, Kazuho, Hiraoka, Kei, Inagaki, Akihito, Takahashi, Mizuna, Kushibiki, Toshihiro, Hontani, Koji, Takano, Hironobu, Sato, Shoki, Takeuchi, Shintaro, Nakamura, Toru, Tsuchikawa, Takahiro, Shichinohe, Toshiaki, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki, Hirano, Satoshi
Published in Cancer gene therapy (01.08.2018)
Published in Cancer gene therapy (01.08.2018)
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Blockade of type I interferon (IFN) production by retroviral replicating vectors and reduced tumor cell responses to IFN likely contribute to tumor selectivity
Lin, Amy H, Burrascano, Cindy, Pettersson, Par L, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J
Published in Journal of virology (01.09.2014)
Published in Journal of virology (01.09.2014)
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Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro
Lin, Amy H., Twitty, Christopher G., Burnett, Ryan, Hofacre, Andrew, Mitchell, Leah A., Espinoza, Fernando Lopez, Gruber, Harry E., Jolly, Douglas J.
Published in Molecular therapy. Nucleic acids (17.03.2017)
Published in Molecular therapy. Nucleic acids (17.03.2017)
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A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models
Yagiz, Kader, Rodriguez-Aguirre, Maria E., Lopez Espinoza, Fernando, Montellano, Tiffany T., Mendoza, Daniel, Mitchell, Leah A., Ibanez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.
Published in Molecular therapy. Oncolytics (30.03.2018)
Published in Molecular therapy. Oncolytics (30.03.2018)
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Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC
Cloughesy, Timothy F, Landolfi, Joseph, Vogelbaum, Michael A, Ostertag, Derek, Elder, James B, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh, Piccioni, David, Accomando, William, Diago, Oscar R, Hogan, Daniel J, Gammon, Dawn, Kasahara, Noriyuki, Kheoh, Thian, Jolly, Douglas J, Gruber, Harry E, Das, Asha, Walbert, Tobias
Published in Neuro-oncology (Charlottesville, Va.) (03.09.2018)
Published in Neuro-oncology (Charlottesville, Va.) (03.09.2018)
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Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model
Mitchell, Leah A, Lopez Espinoza, Fernando, Mendoza, Daniel, Kato, Yuki, Inagaki, Akihito, Hiraoka, Kei, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2017)
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Molecular Analyses Support the Safety and Activity of Retroviral Replicating Vector Toca 511 in Patients
Hogan, Daniel J, Zhu, Jay-Jiguang, Diago, Oscar R, Gammon, Dawn, Haghighi, Ali, Lu, Guangrong, Das, Asha, Gruber, Harry E, Jolly, Douglas J, Ostertag, Derek
Published in Clinical cancer research (01.10.2018)
Published in Clinical cancer research (01.10.2018)
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Molecular and Immunologic Signatures are Related to Clinical Benefit from Treatment with Vocimagene Amiretrorepvec (Toca 511) and 5-Fluorocytosine (Toca FC) in Patients with Glioma
Accomando, William P, Rao, Aliz R, Hogan, Daniel J, Newman, Aaron M, Nakao, Aki, Alizadeh, Ash A, Diehn, Maximilian, Diago, Oscar R, Gammon, Dawn, Haghighi, Ali, Gruber, Harry E, Jolly, Douglas J, Ostertag, Derek
Published in Clinical cancer research (01.12.2020)
Published in Clinical cancer research (01.12.2020)
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Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression
Perez, Omar D, Logg, Christopher R, Hiraoka, Kei, Diago, Oscar, Burnett, Ryan, Inagaki, Akihito, Jolson, Dawn, Amundson, Karin, Buckley, Taylor, Lohse, Dan, Lin, Amy, Burrascano, Cindy, Ibanez, Carlos, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J
Published in Molecular therapy (01.09.2012)
Published in Molecular therapy (01.09.2012)
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Efficient Therapeutic Protein Expression Using Retroviral Replicating Vector with 2A Peptide in Cancer Models
Hofacre, Andrew, Yagiz, Kader, Mendoza, Daniel, Lopez Espinoza, Fernando, Munday, Anthony W, Burrascano, Cynthia, Singer, Oded, Gruber, Harry E, Jolly, Douglas J, Lin, Amy H
Published in Human gene therapy (01.04.2018)
Published in Human gene therapy (01.04.2018)
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Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids
Burnett, Ryan, Ibañez, Carlos E, Pettersson, Pär L, Chen, Ching-I, Parab, Shraddha, Huang, Tiffany, Robbins, Joan, Bankiewicz, Krystof, Aghi, Manish, Logg, Christopher, Kasahara, Noriyuki, Pertschuk, Dan, Gruber, Harry E, Jolly, Douglas J
Published in Molecular therapy. Methods & clinical development (01.01.2014)
Published in Molecular therapy. Methods & clinical development (01.01.2014)
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Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector
Ostertag, Derek, Amundson, Karin K, Lopez Espinoza, Fernando, Martin, Bryan, Buckley, Taylor, Galvão da Silva, Ana Paula, Lin, Amy H, Valenta, David T, Perez, Omar D, Ibañez, Carlos E, Chen, Ching-I, Pettersson, Pär L, Burnett, Ryan, Daublebsky, Veronika, Hlavaty, Juraj, Gunzburg, Walter, Kasahara, Noriyuki, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2012)
Published in Neuro-oncology (Charlottesville, Va.) (01.02.2012)
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Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models
Yagiz, Kader, Huang, Tiffany T, Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E, Gruber, Harry E, Jolly, Douglas J, Robbins, Joan M
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.10.2016)
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Abstract 1413: Treatment of mouse liver and brain colon cancer metastases with Toca 511 and 5-fluorocytosine for intratumoral production of 5-fluorouracil leads to increased survival, induction of antitumor immune responses, and reduction of MDSC
Rodriguez-Aguirre, Maria, Yagiz, Kader, Lopez Espinoza, Fernando, Mendoza, Daniel, Huang, Tiffany T., Ibanez, Carlos, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Retroviral replicating vectors in cancer
Logg, Christopher R, Robbins, Joan M, Jolly, Douglas J, Gruber, Harry E, Kasahara, Noriyuki
Published in Methods in enzymology (2012)
Published in Methods in enzymology (2012)
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Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes
VINCENT, M. F, MARANGOS, P. J, GRUBER, H. E, VAN DEN BERGHE, G
Published in Diabetes (New York, N.Y.) (01.10.1991)
Published in Diabetes (New York, N.Y.) (01.10.1991)
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