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Published in Psychopharmacology (01.04.2021)
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Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization
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Published in Journal of medicinal chemistry (11.09.2008)
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Discovery and Structure−Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the Treatment of Obesity
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Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain
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Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT 2C receptor
Schrader, Thomas O, Kasem, Michelle, Ren, Albert, Feichtinger, Konrad, Al Doori, Bilal, Wei, Jing, Wu, Chunrui, Dang, Huong, Le, Minh, Gatlin, Joel, Chase, Kelli, Dong, Jenny, Whelan, Kevin T, Sage, Carleton, Grottick, Andrew J, Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists
Chaki, Shigeyuki, Funakoshi, Takeo, Hirota-Okuno, Shiho, Nishiguchi, Mariko, Shimazaki, Toshiharu, Iijima, Michihiko, Grottick, Andrew J, Kanuma, Kosuke, Omodera, Katsunori, Sekiguchi, Yoshinori, Okuyama, Shigeru, Tran, Thuy-Anh, Semple, Graeme, Thomsen, William
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
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Nelotanserin, a Novel Selective Human 5-Hydroxytryptamine2A Inverse Agonist for the Treatment of Insomnia
Al-Shamma, Hussien A, Anderson, Christen, Chuang, Emil, Luthringer, Remy, Grottick, Andrew J, Hauser, Erin, Morgan, Michael, Shanahan, William, Teegarden, Bradley R, Thomsen, William J, Behan, Dominic
Published in The Journal of pharmacology and experimental therapeutics (01.01.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2010)
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Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a D 1 but not nicotinic agonist
Grottick, Andrew J, MacQueen, David L, Barnes, Samuel A, Carroll, Chris, Sanabria, Erin K, Bobba, Vishal, Young, Jared W
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Published in Psychopharmacology (Berlin, Germany) (01.04.2021)
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A new family of H3 receptor antagonists based on the natural product Conessine
SANTORA, Vincent J, COVEL, Jonathan A, WEBB, Robert R, SAGE, Carleton, REN, Albert, PEREIRA, Guilherme, KNUDSEN, Jens, EDWARDS, Jeffrey E, SUAREZ, Marissa, FRAZER, John, THOMSEN, William, HAUSER, Erin, HAYASHI, Rena, WHELAN, Kevin, GROTTICK, Andrew J, HOFILENA, Brian J, IBARRA, Jason B, PULLEY, Michelle D, WEINHOUSE, Michael I, SENGUPTA, Dipanjan, DUFFIELD, Jonathan J, SEMPLE, Graeme
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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GPR52 agonists attenuate ropinirole-induced preference for uncertain outcomes
Russell, Brittney, Barrus, Michael M, Tremblay, Melanie, Ma, Lawrence, Hrelja, Kelly, Wong, Christina, Hynes, Tristan J, Hobson, Scott, Grottick, Andrew J, Winstanley, Catharine A
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Published in Behavioral neuroscience (01.02.2021)
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Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)
Semple, Graeme, Santora, Vincent J., Smith, Jeffrey M., Covel, Jonathan A., Hayashi, Rena, Gallardo, Charlemagne, Ibarra, Jason B., Schultz, Jeffrey A., Park, Douglas M., Estrada, Scott A., Hofilena, Brian J., Smith, Brian M., Ren, Albert, Suarez, Marissa, Frazer, John, Edwards, Jeffrey E., Hart, Ryan, Hauser, Erin K., Lorea, Jodie, Grottick, Andrew J.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT2C receptor
Schrader, Thomas O., Zhu, Xiuwen, Kasem, Michelle, Ren, Albert, Liu, Chunyan, Wu, Chunrui, Dang, Huong, Le, Minh, Gatlin, Joel, Chase, Kelli, Frazer, John, Whelan, Kevin T., Grottick, Andrew J., Hutton, Clayton, Barden, Jeremy, Chen, Chuan, Ortiz, Alvaro, Feichtinger, Konrad, Semple, Graeme
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Published in Bioorganic & medicinal chemistry letters (15.04.2021)
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Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays
Ren, Albert, Zhu, Xiuwen, Feichtinger, Konrad, Lehman, Juerg, Kasem, Michelle, Schrader, Thomas O., Wong, Amy, Dang, Huong, Le, Minh, Frazer, John, Unett, David J., Grottick, Andrew J., Whelan, Kevin T., Morgan, Michael E., Sage, Carleton R., Semple, Graeme
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Published in Bioorganic & medicinal chemistry letters (01.03.2020)
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Differential Effects of the 5-HT2A Receptor Antagonist M100,907 and the 5-HT2C Receptor Antagonist SB242,084 on Cocaine-induced Locomotor Activity, Cocaine Self-administration and Cocaine-induced Reinstatement of Responding
Fletcher, Paul J, Grottick, Andrew J, Higgins, Guy A
Published in Neuropsychopharmacology (New York, N.Y.) (01.10.2002)
Published in Neuropsychopharmacology (New York, N.Y.) (01.10.2002)
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Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor
Schrader, Thomas O., Kasem, Michelle, Ren, Albert, Feichtinger, Konrad, Al Doori, Bilal, Wei, Jing, Wu, Chunrui, Dang, Huong, Le, Minh, Gatlin, Joel, Chase, Kelli, Dong, Jenny, Whelan, Kevin T., Sage, Carleton, Grottick, Andrew J., Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
Published in Bioorganic & medicinal chemistry letters (15.12.2016)
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Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control
Semple, Graeme, Ren, Albert, Fioravanti, Beatriz, Pereira, Guillherme, Calderon, Imelda, Choi, Karoline, Xiong, Yifeng, Shin, Young-Jun, Gharbaoui, Tawfik, Sage, Carleton R., Morgan, Michael, Xing, Charles, Chu, Zhi-Liang, Leonard, James N., Grottick, Andrew J., Al-Shamma, Hussein, Liang, Yin, Demarest, Keith T., Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile
Semple, Graeme, Lehmann, Juerg, Wong, Amy, Ren, Albert, Bruce, Marc, Shin, Young-Jun, Sage, Carleton R., Morgan, Michael, Chen, Wei-Chao, Sebring, Kristen, Chu, Zhi-Liang, Leonard, James N., Al-Shamma, Hussein, Grottick, Andrew J., Du, Fuyong, Liang, Yin, Demarest, Keith, Jones, Robert M.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Discovery of APD371: Identification of a Highly Potent and Selective CB 2 Agonist for the Treatment of Chronic Pain
Han, Sangdon, Thoresen, Lars, Jung, Jae-Kyu, Zhu, Xiuwen, Thatte, Jayant, Solomon, Michelle, Gaidarov, Ibragim, Unett, David J, Yoon, Woo Hyun, Barden, Jeremy, Sadeque, Abu, Usmani, Amin, Chen, Chuan, Semple, Graeme, Grottick, Andrew J, Al-Shamma, Hussein, Christopher, Ronald, Jones, Robert M
Published in ACS medicinal chemistry letters (14.12.2017)
Published in ACS medicinal chemistry letters (14.12.2017)
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