The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment
Poon, Edmund, Mullins, Stefanie, Watkins, Amanda, Williams, Geoffrey S, Koopmann, Jens-Oliver, Di Genova, Gianfranco, Cumberbatch, Marie, Veldman-Jones, Margaret, Grosskurth, Shaun E, Sah, Vasu, Schuller, Alwin, Reimer, Corrine, Dovedi, Simon J, Smith, Paul D, Stewart, Ross, Wilkinson, Robert W
Published in Journal for immunotherapy of cancer (15.08.2017)
Published in Journal for immunotherapy of cancer (15.08.2017)
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Journal Article
Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma
Ezell, Scott A, Mayo, Michele, Bihani, Teeru, Tepsuporn, Suprawee, Wang, Suping, Passino, Melissa, Grosskurth, Shaun E, Collins, Mike, Parmentier, Julie, Reimer, Corinne, Byth, Kate F
Published in Oncotarget (15.07.2014)
Published in Oncotarget (15.07.2014)
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Journal Article
Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression[S]
Ruangsiriluk, Wanida, Grosskurth, Shaun E., Ziemek, Daniel, Kuhn, Max, des Etages, Shelley G., Francone, Omar L.
Published in Journal of lipid research (01.08.2012)
Published in Journal of lipid research (01.08.2012)
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Journal Article
Emergence of Xin demarcates a key innovation in heart evolution
Grosskurth, Shaun E, Bhattacharya, Debashish, Wang, Qinchuan, Lin, Jim Jung-Ching
Published in PloS one (06.08.2008)
Published in PloS one (06.08.2008)
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Journal Article
AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition
Scarborough, Hannah A, Helfrich, Barbara A, Casás-Selves, Matias, Schuller, Alwin G, Grosskurth, Shaun E, Kim, Jihye, Tan, Aik-Choon, Chan, Daniel C, Zhang, Zhiyong, Zaberezhnyy, Vadym, Bunn, Paul A, DeGregori, James
Published in Clinical cancer research (15.03.2017)
Published in Clinical cancer research (15.03.2017)
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Journal Article
Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer
Wang, Zebin, Grosskurth, Shaun E, Cheung, Tony, Petteruti, Philip, Zhang, Jingwen, Wang, Xin, Wang, Wenxian, Gharahdaghi, Farzin, Wu, Jiaquan, Su, Nancy, Howard, Ryan T, Mayo, Michele, Widzowski, Dan, Scott, David A, Johannes, Jeffrey W, Lamb, Michelle L, Lawson, Deborah, Dry, Jonathan R, Lyne, Paul D, Tate, Edward W, Zinda, Michael, Mikule, Keith, Fawell, Stephen E, Reimer, Corinne, Chen, Huawei
Published in Cancer research (Chicago, Ill.) (01.12.2018)
Published in Cancer research (Chicago, Ill.) (01.12.2018)
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Journal Article
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Zhang, Qi, Riley-Gillis, Bridget, Han, Lina, Jia, Yannan, Lodi, Alessia, Zhang, Haijiao, Ganesan, Saravanan, Pan, Rongqing, Konoplev, Sergej N, Sweeney, Shannon R, Ryan, Jeremy A, Jitkova, Yulia, Dunner, Jr, Kenneth, Grosskurth, Shaun E, Vijay, Priyanka, Ghosh, Sujana, Lu, Charles, Ma, Wencai, Kurtz, Stephen, Ruvolo, Vivian R, Ma, Helen, Weng, Connie C, Ramage, Cassandra L, Baran, Natalia, Shi, Ce, Cai, Tianyu, Davis, Richard Eric, Battula, Venkata L, Mi, Yingchang, Wang, Jing, DiNardo, Courtney D, Andreeff, Michael, Tyner, Jeffery W, Schimmer, Aaron, Letai, Anthony, Padua, Rose Ann, Bueso-Ramos, Carlos E, Tiziani, Stefano, Leverson, Joel, Popovic, Relja, Konopleva, Marina
Published in Signal transduction and targeted therapy (21.02.2022)
Published in Signal transduction and targeted therapy (21.02.2022)
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Journal Article
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering
Johannes, Jeffrey W., Almeida, Lynsie, Daly, Kevin, Ferguson, Andrew D., Grosskurth, Shaun E., Guan, Huiping, Howard, Tina, Ioannidis, Stephanos, Kazmirski, Steven, Lamb, Michelle L., Larsen, Nicholas A., Lyne, Paul D., Mikule, Keith, Ogoe, Claude, Peng, Bo, Petteruti, Philip, Read, Jon A., Su, Nancy, Sylvester, Mark, Throner, Scott, Wang, Wenxian, Wang, Xin, Wu, Jiaquan, Ye, Qing, Yu, Yan, Zheng, Xiaolan, Scott, David A.
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
Published in Bioorganic & medicinal chemistry letters (15.12.2015)
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Journal Article
Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers
Bihani, Teeru, Ezell, Scott A, Ladd, Brendon, Grosskurth, Shaun E, Mazzola, Anne Marie, Pietras, Mark, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M
Published in Oncotarget (10.02.2015)
Published in Oncotarget (10.02.2015)
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Journal Article
Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma
Ezell, Scott A, Wang, Suping, Bihani, Teeru, Lai, Zhongwu, Grosskurth, Shaun E, Tepsuporn, Suprawee, Davies, Barry R, Huszar, Dennis, Byth, Kate F
Published in Oncotarget (23.02.2016)
Published in Oncotarget (23.02.2016)
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Journal Article
Small RNA Sequencing to Discover Circulating MicroRNA Biomarkers of Testicular Toxicity in Dogs
Shing, Jennifer C, Schaefer, Kai, Grosskurth, Shaun E, Vo, Andy H, Sharapova, Tatiana, Bodié, Karen, Kambara, Takahito, Buck, Wayne R
Published in International journal of toxicology (01.01.2021)
Published in International journal of toxicology (01.01.2021)
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Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia
Zhang, Qi, Riley-Gillis, Bridget, Han, Lina, Jia, Yannan, Lodi, Alessia, Zhang, Haijiao, Ganesan, Saravanan, Pan, Rongqing, Konoplev, Sergej N, Sweeney, Shannon R, Ryan, Jeremy A, Jitkova, Yulia, Dunner, Jr, Kenneth, Grosskurth, Shaun E, Vijay, Priyanka, Ghosh, Sujana, Lu, Charles, Ma, Wencai, Kurtz, Stephen, Ruvolo, Vivian R, Ma, Helen, Weng, Connie C, Ramage, Cassandra L, Baran, Natalia, Shi, Ce, Cai, Tianyu, Davis, Richard Eric, Battula, Venkata L, Mi, Yingchang, Wang, Jing, DiNardo, Courtney D, Andreeff, Michael, Tyner, Jeffery W, Schimmer, Aaron, Letai, Anthony, Padua, Rose Ann, Bueso-Ramos, Carlos E, Tiziani, Stefano, Leverson, Joel, Popovic, Relja, Konopleva, Marina
Published in Signal transduction and targeted therapy (01.04.2022)
Published in Signal transduction and targeted therapy (01.04.2022)
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Journal Article
Characterization of cis-regulatory elements and transcription factor binding: gel mobility shift assay
Lin, Jim Jung-Ching, Grosskurth, Shaun E, Harlan, Shannon M, Gustafson-Wagner, Elisabeth A, Wang, Qin
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2007)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2007)
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