An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three‐month randomized, placebo‐controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
Genovese, Mark C., Kavanaugh, Arthur, Weinblatt, Michael E., Peterfy, Charles, DiCarlo, Julie, White, Michael L., O'Brien, Maryann, Grossbard, Elliott B., Magilavy, Daniel B.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2011)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.02.2011)
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R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation
Braselmann, Sylvia, Taylor, Vanessa, Zhao, Haoran, Wang, Su, Sylvain, Catherine, Baluom, Muhammad, Qu, Kunbin, Herlaar, Ellen, Lau, Angela, Young, Chi, Wong, Brian R, Lovell, Scott, Sun, Thomas, Park, Gary, Argade, Ankush, Jurcevic, Stipo, Pine, Polly, Singh, Rajinder, Grossbard, Elliott B, Payan, Donald G, Masuda, Esteban S
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2006)
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Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies
Baluom, Muhammad, Grossbard, Elliott B., Mant, Tim, Lau, David T. W.
Published in British journal of clinical pharmacology (01.07.2013)
Published in British journal of clinical pharmacology (01.07.2013)
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Effects of fostamatinib (R788), an oral spleen tyrosine kinase inhibitor, on health-related quality of life in patients with active rheumatoid arthritis: analyses of patient-reported outcomes from a randomized, double-blind, placebo-controlled trial
Weinblatt, Michael E, Kavanaugh, Arthur, Genovese, Mark C, Jones, David A, Musser, Theresa K, Grossbard, Elliott B, Magilavy, Daniel B
Published in Journal of rheumatology (01.04.2013)
Published in Journal of rheumatology (01.04.2013)
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Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor
Pine, Polly R, Chang, Betty, Schoettler, Nathan, Banquerigo, Mona L, Wang, Su, Lau, Angela, Zhao, Feifei, Grossbard, Elliott B, Payan, Donald G, Brahn, Ernest
Published in Clinical Immunology (01.09.2007)
Published in Clinical Immunology (01.09.2007)
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Metabolism of Fostamatinib, the Oral Methylene Phosphate Prodrug of the Spleen Tyrosine Kinase Inhibitor R406 in Humans: Contribution of Hepatic and Gut Bacterial Processes to the Overall Biotransformation
SWEENY, David J, WEIQUN LI, CLOUGH, Jeffrey, BHAMIDIPATI, Somasekhar, SINGH, Rajinder, PARK, Gary, BALUOM, Muhammad, GROSSBARD, Elliott, LAU, David T.-W
Published in Drug metabolism and disposition (01.07.2010)
Published in Drug metabolism and disposition (01.07.2010)
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JAK3 Inhibition Significantly Attenuates Psoriasiform Skin Inflammation in CD18 Mutant PL/J Mice
Chang, Betty Y, Zhao, Feifei, He, Xiaodong, Ren, Hong, Braselmann, Sylvia, Taylor, Vanessa, Wicks, Joan, Payan, Donald G, Grossbard, Elliott B, Pine, Polly R, Bullard, Daniel C
Published in The Journal of immunology (1950) (01.08.2009)
Published in The Journal of immunology (1950) (01.08.2009)
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Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies
Martin, Paul, Gillen, Michael, Millson, David, Oliver, Stuart, Brealey, Clive, Grossbard, Elliott B., Baluom, Muhammad, Lau, David, Sweeny, David, Mant, Tim, Craven, Kelli
Published in Drugs in R&D (01.03.2016)
Published in Drugs in R&D (01.03.2016)
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Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing
Clemens, George R, Schroeder, Raymond E, Magness, Steven H, Weaver, Elizabeth V, Lech, Joseph W, Taylor, Vanessa C, Masuda, Esteban S, Baluom, Muhammad, Grossbard, Elliott B
Published in Birth defects research. A Clinical and molecular teratology (01.02.2009)
Published in Birth defects research. A Clinical and molecular teratology (01.02.2009)
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Targeting Syk as a treatment for allergic and autoimmune disorders
Wong, Brian R, Grossbard, Elliott B, Payan, Donald G, Masuda, Esteban S
Published in Expert opinion on investigational drugs (01.07.2004)
Published in Expert opinion on investigational drugs (01.07.2004)
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An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus
Bahjat, Frances Rena, Pine, Polly R., Reitsma, Andrea, Cassafer, Gail, Baluom, Muhammad, Grillo, Sunny, Chang, Betty, Zhao, Fei Fei, Payan, Donald G., Grossbard, Elliott B., Daikh, David I.
Published in Arthritis and rheumatism (01.05.2008)
Published in Arthritis and rheumatism (01.05.2008)
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Human Brain Natriuretic Peptide Reduces Blood Pressure in Normotensive and Acute Norepinephrine-Induced Hypertensive Rabbits
Clemens, L.Edward, Almirez, Ramona G, Baudouin, Karine A, Grossbard, Elliott B, Protter, Andrew A
Published in American journal of hypertension (01.06.1997)
Published in American journal of hypertension (01.06.1997)
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A perfluorochemical emulsion for prehospital resuscitation of experimental hemorrhagic shock: a prospective, randomized, controlled study
Goodin, T H, Grossbard, E B, Kaufman, R J, Richard, T J, Kolata, R J, Allen, J S, Layton, T E
Published in Critical care medicine (01.04.1994)
Published in Critical care medicine (01.04.1994)
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Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen
McLaughlin, John, Markovtsov, Vadim, Li, Hui, Wong, Steve, Gelman, Marina, Zhu, Yanhong, Franci, Christian, Lang, D. Wayne, Pali, Erlina, Lasaga, Joe, Low, Caroline, Zhao, Feifei, Chang, Betty, Gururaja, Tarikere L, Xu, Weiduan, Baluom, Muhammad, Sweeny, David, Carroll, David, Sran, Arvinder, Thota, Sambaiah, Parmer, Manjeet, Romane, Angela, Clemens, George, Grossbard, Elliott, Qu, Kunbin, Jenkins, Yonchu, Kinoshita, Taisei, Taylor, Vanessa, Holland, Sacha J, Argade, Ankush, Singh, Rajinder, Pine, Polly, Payan, Donald G, Hitoshi, Yasumichi
Published in Journal of cancer research and clinical oncology (2010)
Published in Journal of cancer research and clinical oncology (2010)
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Pharmacokinetics and Biological Actions of Subcutaneously Administered Human Brain Natriuretic Peptide
Clemens, L E, Almirez, R G, Baudouin, K A, Mischak, R P, Grossbard, E B, Protter, A A
Published in The Journal of pharmacology and experimental therapeutics (01.10.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.10.1998)
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