Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models
Zenke, Frank T, Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Kirkin, Vladimir, Pehl, Ulrich, Grombacher, Thomas, Wilm, Claudia, Fuchss, Thomas, Amendt, Christiane, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.05.2020)
Published in Molecular cancer therapeutics (01.05.2020)
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Journal Article
A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Mapping combinatorial drug effects to DNA damage response kinase inhibitors
Zhang, Hanrui, Kreis, Julian, Schelhorn, Sven-Eric, Dahmen, Heike, Grombacher, Thomas, Zühlsdorf, Michael, Zenke, Frank T., Guan, Yuanfang
Published in Nature communications (14.12.2023)
Published in Nature communications (14.12.2023)
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RosettaSX: Reliable gene expression signature scoring of cancer models and patients
Kreis, Julian, Nedić, Boro, Mazur, Johanna, Urban, Miriam, Schelhorn, Sven-Eric, Grombacher, Thomas, Geist, Felix, Brors, Benedikt, Zühlsdorf, Michael, Staub, Eike
Published in Neoplasia (New York, N.Y.) (01.11.2021)
Published in Neoplasia (New York, N.Y.) (01.11.2021)
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Journal Article
Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer
Telli, Melinda L., Tolaney, Sara M., Shapiro, Geoffrey I., Middleton, Mark, Lord, Simon R., Arkenau, Hendrik Tobias, Tutt, Andrew, Abramson, Vandana, Dean, Emma, Haddad, Tufia C., Wesolowski, Robert, Ferrer-Playan, Jordi, Goddemeier, Thomas, Grombacher, Thomas, Dong, Jennifer, Fleuranceau-Morel, Patricia, Diaz-Padilla, Ivan, Plummer, Ruth
Published in NPJ breast cancer (07.04.2022)
Published in NPJ breast cancer (07.04.2022)
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First-in-Human Study of the Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors
Yap, Timothy A, Tolcher, Anthony W, Plummer, Ruth, Mukker, Jatinder Kaur, Enderlin, Marta, Hicking, Christine, Grombacher, Thomas, Locatelli, Giuseppe, Szucs, Zoltan, Gounaris, Ioannis, de Bono, Johann S
Published in Clinical cancer research (15.05.2024)
Published in Clinical cancer research (15.05.2024)
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Implementation of whole-exome sequencing for pharmacogenomics profiling and exploring its potential clinical utilities
Wang, Danyi, Bolleddula, Jayaprakasam, Coenen-Stass, Anna, Grombacher, Thomas, Dong, Jennifer Q, Scheuenpflug, Juergen, Locatelli, Giuseppe, Feng, Zheng
Published in Pharmacogenomics (01.03.2024)
Published in Pharmacogenomics (01.03.2024)
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Journal Article
Abstract 4183: A novel selective DNA-PK inhibitor, M3814, as a potential combination partner of Etoposide and Cisplatin in the therapy of lung cancer
Sirrenberg, Christian, Zimmermann, Astrid, Grombacher, Thomas, Vassilev, Lyubomir T., Damstrup, Lars, Zenke, Frank T., Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 338: A new investigational ATM Inhibitor, M3541, synergistically potentiates fractionated radiotherapy and chemotherapy in cancer cells and animal models
Zimmermann, Astrid, Zenke, Frank, Dahmen, Heike, Sirrenberg, Christian, Grombacher, Thomas, Vassilev, Lyubomir T., Fuchss, Thomas, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2588: M1774, a novel potent and selective ATR inhibitor, shows antitumor effects as monotherapy and in combination
Zimmermann, Astrid, Dahmen, Heike, Grombacher, Thomas, Pehl, Ulrich, Blaukat, Andree, Zenke, Frank T.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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대상체에서의 암을 치료하기 위한 화합물 및 이의 용도
DAHMEN HEIKE, ZIMMERMANN ASTRID, GROMBACHER THOMAS, ORTIZ RUIZ MARIA JESUS
Year of Publication 23.11.2020
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Year of Publication 23.11.2020
Patent
Abstract CT271: Translational analyses of ATR inhibitor M1774 in a Phase I study in patients with solid tumors (DDRiver Solid Tumors 301)
Tolcher, Anthony W., Yap, Timothy A., Plummer, Ruth, Grombacher, Thomas, Wang, Danyi, Schaffroth, Corinna, Hicking, Christine, Szucs, Zoltan, Locatelli, Giuseppe, de Bono, Johann S.
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation
Grombacher, Thomas, Kaina, Bernd
Published in Biochimica et biophysica acta. Molecular basis of disease (01.01.1995)
Published in Biochimica et biophysica acta. Molecular basis of disease (01.01.1995)
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단백질 키나제 억제제 및 추가 화학요법제의 조합물
DAMSTRUP LARS, VASSILEV LYUBOMIR, ZIMMERMANN ASTRID, GROMBACHER THOMAS, SIRRENBERG CHRISTIAN
Year of Publication 26.08.2019
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Year of Publication 26.08.2019
Patent
Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms
Kaina, B, Fritz, G, Ochs, K, Haas, S, Grombacher, T, Dosch, J, Christmann, M, Lund, P, Gregel, C M, Becker, K
Published in Mutation research (20.09.1998)
Published in Mutation research (20.09.1998)
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COMBINATION OF A PROTEIN KINASE INHIBITOR AND AN ADDITIONAL CHEMOTHERAPEUTIC AGENT
DAMSTRUP, LARS, GROMBACHER, THOMAS, VASSILEV, LYUBOMIR, ZIMMERMANN, ASTRID, SIRRENBERG, CHRISTIAN
Year of Publication 04.07.2023
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Year of Publication 04.07.2023
Patent