TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity
Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Bradaia, Amyaouch, Sotnikova, Tatyana D, Mory, Roland, Durkin, Sean, Zbinden, Katrin Groebke, Norcross, Roger, Meyer, Claas A, Metzler, Veit, Chaboz, Sylvie, Ozmen, Laurence, Trube, Gerhard, Pouzet, Bruno, Bettler, Bernhard, Caron, Marc G, Wettstein, Joseph G, Hoener, Marius C
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (17.05.2011)
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Journal Article
Computational Predictions of Nonclinical Pharmacokinetics at the Drug Design Stage
Stoyanova, Raya, Katzberger, Paul Maximilian, Komissarov, Leonid, Khadhraoui, Aous, Sach-Peltason, Lisa, Groebke Zbinden, Katrin, Schindler, Torsten, Manevski, Nenad
Published in Journal of chemical information and modeling (23.01.2023)
Published in Journal of chemical information and modeling (23.01.2023)
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Journal Article
Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
Revel, Florent G, Moreau, Jean-Luc, Gainetdinov, Raul R, Ferragud, Antonio, Velázquez-Sánchez, Clara, Sotnikova, Tatyana D, Morairty, Stephen R, Harmeier, Anja, Groebke Zbinden, Katrin, Norcross, Roger D, Bradaia, Amyaouch, Kilduff, Thomas S, Biemans, Barbara, Pouzet, Bruno, Caron, Marc G, Canales, Juan J, Wallace, Tanya L, Wettstein, Joseph G, Hoener, Marius C
Published in Biological psychiatry (1969) (01.12.2012)
Published in Biological psychiatry (1969) (01.12.2012)
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Journal Article
Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
Zbinden, Katrin Groebke, Banner, David W., Hilpert, Kurt, Himber, Jacques, Lavé, Thierry, Riederer, Markus A., Stahl, Martin, Tschopp, Thomas B., Obst-Sander, Ulrike
Published in Bioorganic & medicinal chemistry (01.08.2006)
Published in Bioorganic & medicinal chemistry (01.08.2006)
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Journal Article
Discovery of a factor Xa inhibitor (3 R,4 R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidate
Anselm, Lilli, Banner, David W., Benz, Jörg, Groebke Zbinden, Katrin, Himber, Jacques, Hilpert, Hans, Huber, Walter, Kuhn, Bernd, Mary, Jean-Luc, Otteneder, Michael B., Panday, Narendra, Ricklin, Fabienne, Stahl, Martin, Thomi, Stefan, Haap, Wolfgang
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
Zbinden, Katrin Groebke, Obst-Sander, Ulrike, Hilpert, Kurt, Kühne, Holger, Banner, David W., Böhm, Hans-Joachim, Stahl, Martin, Ackermann, Jean, Alig, Leo, Weber, Lutz, Wessel, Hans Peter, Riederer, Markus A., Tschopp, Thomas B., Lavé, Thierry
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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Journal Article
Discovery and Characterization of 2‑Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists
Galley, Guido, Beurier, Angélica, Décoret, Guillaume, Goergler, Annick, Hutter, Roman, Mohr, Susanne, Pähler, Axel, Schmid, Philipp, Türck, Dietrich, Unger, Robert, Zbinden, Katrin Groebke, Hoener, Marius C, Norcross, Roger D
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Journal Article
Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit
Zbinden, Katrin Groebke, Anselm, Lilli, Banner, David W., Benz, Jörg, Blasco, Francesca, Décoret, Guillaume, Himber, Jacques, Kuhn, Bernd, Panday, Narendra, Ricklin, Fabienne, Risch, Philippe, Schlatter, Daniel, Stahl, Martin, Thomi, Stefan, Unger, Robert, Haap, Wolfgang
Published in European journal of medicinal chemistry (01.07.2009)
Published in European journal of medicinal chemistry (01.07.2009)
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Journal Article
Isoxazolyl ether derivatives as GABAA α5 PAM
Steiner, Sandra, Pinard, Emmanuel, Cecere, Giuseppe, Hernandez, Maria-Clemencia, Zbinden, Katrin Groebke, Koblet, Andreas, Olivares Morales, Andres Miguel, Runtz-Schmitt, Valerie, Knust, Henner, Patiny-Adam, Angélique
Year of Publication 12.12.2023
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Year of Publication 12.12.2023
Patent
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate
Anselm, Lilli, Banner, David W, Benz, Jörg, Zbinden, Katrin Groebke, Himber, Jacques, Hilpert, Hans, Huber, Walter, Kuhn, Bernd, Mary, Jean-Luc, Otteneder, Michael B, Panday, Narendra, Ricklin, Fabienne, Stahl, Martin, Thomi, Stefan, Haap, Wolfgang
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Template-Nucleated Alanine-Lysine Helices are Stabilized by Position-Dependent Interactions between the Lysine Side Chain and the Helix Barrel
Groebke, Katrin, Renold, Peter, Tsang, Kwok Yin, Allen, Thomas J., McClure, Kim F., Kemp, D. S.
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (30.04.1996)
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Journal Article
derivados de 4,5-di-hidro-oxazol-2-ila
Roger Norcross, Guido Galley, Katrin Groebke Zbinden, Annick Goergler
Year of Publication 29.05.2018
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Year of Publication 29.05.2018
Patent
processo para a preparação de derivados de ácido carboxílico de pirazol
BJOERN BARTELS, FRIITZ BLISS, KATRIN GROEBKE ZBINDEN, MATTHIAS KOERNER
Year of Publication 19.12.2017
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Year of Publication 19.12.2017
Patent
NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM
Steiner, Sandra, Pinard, Emmanuel, Cecere, Giuseppe, Hernandez, Maria-Clemencia, Zbinden, Katrin Groebke, Koblet, Andreas, Olivares Morales, Andres Miguel, Runtz-Schmitt, Valerie, Knust, Henner, Patiny-Adam, Angélique
Year of Publication 01.04.2021
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Year of Publication 01.04.2021
Patent
Pyrrolidino heterocycles
Zbinden Katrin Groebke, Lerner Christian, Koerner Matthias, Flohr Alexander
Year of Publication 10.01.2017
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Year of Publication 10.01.2017
Patent
Indol and indazol derivatives
Pinard Emmanuel, Ballard Theresa M, Zbinden Katrin Groebke, Schaffhauser Herve, Blanc Jean-Baptiste, Ryckmans Thomas
Year of Publication 18.07.2017
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Year of Publication 18.07.2017
Patent
PYRROLIDINO HETEROCYCLES
FLOHR ALEXANDER, ZBINDEN KATRIN GROEBKE, KOERNER MATTHIAS, LERNER CHRISTIAN
Year of Publication 26.03.2015
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Year of Publication 26.03.2015
Patent