Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes
Wallin, Jeffrey J, Guan, Jane, Edgar, Kyle A, Zhou, Wei, Francis, Ross, Torres, Anthony C, Haverty, Peter M, Eastham-Anderson, Jeffrey, Arena, Sabrina, Bardelli, Alberto, Griffin, Sue, Goodall, John E, Grimshaw, Kyla M, Hoeflich, Klaus P, Torrance, Christopher, Belvin, Marcia, Friedman, Lori S
Published in PloS one (03.05.2012)
Published in PloS one (03.05.2012)
Get full text
Journal Article
AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
YAP, Timothy A, WALTON, Mike I, HEINZMANN, Kathrin, JONES, Paul S, FELTELL, Ruth E, REULE, Matthias, WOODHEAD, Steven J, DAVIES, Thomas G, LYONS, John F, RAYNAUD, Florence I, ECCLES, Suzanne A, WORKMAN, Paul, GRIMSHAW, Kyla M, THOMPSON, Neil T, GARRETT, Michelle D, TE POELE, Robert H, EVE, Paul D, VALENTI, Melanie R, DE HAVEN BRANDON, Alexis K, MARTINS, Vanessa, ZETTERLUND, Anna, HEATON, Simon P
Published in Clinical cancer research (15.07.2012)
Published in Clinical cancer research (15.07.2012)
Get full text
Journal Article
AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth
Grimshaw, Kyla M, Hunter, Lisa-Jane K, Yap, Timothy A, Heaton, Simon P, Walton, Mike I, Woodhead, Steven J, Fazal, Lynsey, Reule, Matthias, Davies, Thomas G, Seavers, Lisa C, Lock, Victoria, Lyons, John F, Thompson, Neil T, Workman, Paul, Garrett, Michelle D
Published in Molecular cancer therapeutics (01.05.2010)
Published in Molecular cancer therapeutics (01.05.2010)
Get full text
Journal Article
Abstract 928: The novel clinical candidate AT13148 is an oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity and demonstrates a mechanism of action distinct from AKT inhibitors
Yap, Timothy A., Walton, Michael I., Grimshaw, Kyla M., Poele, Robert H. te, Eve, Paul D., Valenti, Melanie R., de Haven Brandon, Alexis K., Martins, Vanessa, Zetterlund, Anna, Heaton, Simon P., Heinzmann, Kathrin, Jones, Paul S., Feltell, Ruth E., Reule, Matthias, Woodhead, Steven J., Davies, Thomas G., Lyons, John F., Raynaud, Florence I., Eccles, Suzanne A., Workman, Paul, Thompson, Neil T., Garrett, Michelle D.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Get full text
Journal Article