Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer
Lu, Yunlong, Gutgesell, Lauren M, Xiong, Rui, Zhao, Jiong, Li, Yangfeng, Rosales, Carlo I, Hollas, Michael, Shen, Zhengnan, Gordon-Blake, Jesse, Dye, Katherine, Wang, Yueting, Lee, Sue, Chen, Hu, He, Donghong, Dubrovyskyii, Oleksii, Zhao, Huiping, Huang, Fei, Lasek, Amy W, Tonetti, Debra A, Thatcher, Gregory R. J
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
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Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo
Petukhova, Valentina Z., Aboagye, Sammy Y., Ardini, Matteo, Lullo, Rachel P., Fata, Francesca, Byrne, Margaret E., Gabriele, Federica, Martin, Lucy M., Harding, Luke N. M., Gone, Vamshikrishna, Dangi, Bikash, Lantvit, Daniel D., Nikolic, Dejan, Ippoliti, Rodolfo, Effantin, Grégory, Ling, Wai Li, Johnson, Jeremy J., Thatcher, Gregory R. J., Angelucci, Francesco, Williams, David L., Petukhov, Pavel A.
Published in Nature communications (22.06.2023)
Published in Nature communications (22.06.2023)
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Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry
Schafer, Adam, Xiong, Rui, Cooper, Laura, Nowar, Raghad, Lee, Hyun, Li, Yangfeng, Ramirez, Benjamin E, Peet, Norton P, Caffrey, Michael, Thatcher, Gregory R J, Saphire, Erica Ollmann, Cheng, Han, Rong, Lijun
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Published in PLoS pathogens (01.02.2021)
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Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity
Shen, Zhengnan, Ratia, Kiira, Cooper, Laura, Kong, Deyu, Lee, Hyun, Kwon, Youngjin, Li, Yangfeng, Alqarni, Saad, Huang, Fei, Dubrovskyi, Oleksii, Rong, Lijun, Thatcher, Gregory R. J., Xiong, Rui
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons
Yu, Lei, Tasaki, Shinya, Schneider, Julie A, Arfanakis, Konstantinos, Duong, Duc M, Wingo, Aliza P, Wingo, Thomas S, Kearns, Nicola, Thatcher, Gregory R J, Seyfried, Nicholas T, Levey, Allan I, De Jager, Philip L, Bennett, David A
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Published in JAMA psychiatry (Chicago, Ill.) (01.11.2020)
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Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer
Xiong, Rui, Zhao, Jiong, Gutgesell, Lauren M, Wang, Yueting, Lee, Sue, Karumudi, Bhargava, Zhao, Huiping, Lu, Yunlong, Tonetti, Debra A, Thatcher, Gregory R. J
Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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Redox Cycling of Catechol Estrogens Generating Apurinic/Apyrimidinic Sites and 8-oxo-Deoxyguanosine via Reactive Oxygen Species Differentiates Equine and Human Estrogens
Wang, Zhican, Chandrasena, Esala R, Yuan, Yang, Peng, Kuan-wei, van Breemen, Richard B, Thatcher, Gregory R. J, Bolton, Judy L
Published in Chemical research in toxicology (16.08.2010)
Published in Chemical research in toxicology (16.08.2010)
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MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3
Singh, Sunil Kumar, Kumar, Sandeep, Viswakarma, Navin, Principe, Daniel R., Das, Subhasis, Sondarva, Gautam, Nair, Rakesh Sathish, Srivastava, Piush, Sinha, Subhash C., Grippo, Paul J., Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay
Published in Oncogene (28.10.2021)
Published in Oncogene (28.10.2021)
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An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk
VandeVrede, Lawren, Abdelhamid, Ramy, Qin, Zhihui, Choi, Jaewoo, Piyankarage, Sujeewa, Luo, Jia, Larson, John, Bennett, Brian M, Thatcher, Gregory R J
Published in PloS one (16.08.2013)
Published in PloS one (16.08.2013)
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TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer
Nair, Rakesh Sathish, Kumar, Sandeep, Das, Subhasis, Singh, Sunil Kumar, Srivastava, Piush, Sondarva, Gautam, Rao, Arundhati, Sinha, Subhash C., Xiong, Rui, Bloem, Laura, Hoskins, Kent, Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay
Published in Oncogene (30.03.2023)
Published in Oncogene (30.03.2023)
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Quinone-Induced Activation of Keap1/Nrf2 Signaling by Aspirin Prodrugs Masquerading as Nitric Oxide
Dunlap, Tareisha, Piyankarage, Sujeewa C, Wijewickrama, Gihani T, Abdul-Hay, Samer, Vanni, Michael, Litosh, Vladislav, Luo, Jia, Thatcher, Gregory R. J
Published in Chemical research in toxicology (17.12.2012)
Published in Chemical research in toxicology (17.12.2012)
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Discovery and Structural Optimization of 4‑(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections
Gaisina, Irina N, Peet, Norton P, Wong, Letitia, Schafer, Adam M, Cheng, Han, Anantpadma, Manu, Davey, Robert A, Thatcher, Gregory R. J, Rong, Lijun
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib
Li, Yangfeng, Zhao, Jiong, Gutgesell, Lauren M, Shen, Zhengnan, Ratia, Kiira, Dye, Katherine, Dubrovskyi, Oleksii, Zhao, Huiping, Huang, Fei, Tonetti, Debra A, Thatcher, Gregory R. J, Xiong, Rui
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Optimization of 4‑Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir
Gaisina, Irina N, Peet, Norton P, Cheng, Han, Li, Ping, Du, Ruikun, Cui, Qinghua, Furlong, Kevin, Manicassamy, Balaji, Caffrey, Michael, Thatcher, Gregory R. J, Rong, Lijun
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation
Valencia-Olvera, Ana C., Balu, Deebika, Faulk, Naomi, Amiridis, Aspasia, Wang, Yueting, Pham, Christine, Avila-Munoz, Eva, York, Jason M., Thatcher, Gregory R.J., LaDu, Mary Jo
Published in Neurotherapeutics (01.07.2023)
Published in Neurotherapeutics (01.07.2023)
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Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors
Cooper, Laura, Schafer, Adam, Li, Yangfeng, Cheng, Han, Medegan Fagla, Bani, Shen, Zhengnan, Nowar, Raghad, Dye, Katherine, Anantpadma, Manu, Davey, Robert A, Thatcher, Gregory R. J, Rong, Lijun, Xiong, Rui
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe
Yao, Yao, Delgado-Rivera, Loruhama, Samareh Afsari, Hamid, Yin, Liang, Thatcher, Gregory R. J, Moore, Terry W, Miller, Lawrence W
Published in Inorganic chemistry (16.01.2018)
Published in Inorganic chemistry (16.01.2018)
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G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer
Andreano, Kaitlyn J., Wardell, Suzanne E., Baker, Jennifer G., Desautels, Taylor K., Baldi, Robert, Chao, Christina A., Heetderks, Kendall A., Bae, Yeeun, Xiong, Rui, Tonetti, Debra A., Gutgesell, Lauren M., Zhao, Jiong, Sorrentino, Jessica A., Thompson, Delita A., Bisi, John E., Strum, Jay C., Thatcher, Gregory R. J., Norris, John D.
Published in Breast cancer research and treatment (01.04.2020)
Published in Breast cancer research and treatment (01.04.2020)
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