Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota
Tam, John, Hamza, Therwa, Ma, Bing, Chen, Kevin, Beilhartz, Greg L., Ravel, Jacques, Feng, Hanping, Melnyk, Roman A.
Published in Nature communications (07.12.2018)
Published in Nature communications (07.12.2018)
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Journal Article
An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies
Gill, Shivneet K, Sugiman-Marangos, Seiji N, Beilhartz, Greg L, Mei, Elizabeth, Taipale, Mikko, Melnyk, Roman A
Published in EMBO molecular medicine (14.10.2024)
Published in EMBO molecular medicine (14.10.2024)
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Journal Article
Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore
Zhang, Zhifen, Park, Minyoung, Tam, John, Auger, Anick, Beilhartz, Greg L., Lacy, D. Borden, Melnyk, Roman A.
Published in Proceedings of the National Academy of Sciences - PNAS (11.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (11.03.2014)
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Journal Article
Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells
Park, Minyoung, Xu, Xiaobai, Min, Weixian, Sugiman-Marangos, Seiji N, Beilhartz, Greg L, Adams, Jarret J, Sidhu, Sachdev S, Grunebaum, Eyal, Melnyk, Roman A
Published in Molecular pharmaceutics (05.11.2018)
Published in Molecular pharmaceutics (05.11.2018)
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Journal Article
HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors
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Journal Article
Book Review
Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms
Ehteshami, Maryam, Beilhartz, Greg L., Scarth, Brian J., Tchesnokov, Egor P., McCormick, Suzanne, Wynhoven, Brian, Harrigan, P.Richard, Götte, Matthias
Published in The Journal of biological chemistry (08.08.2008)
Published in The Journal of biological chemistry (08.08.2008)
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Journal Article
HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition
Beilhartz, Greg L., Wendeler, Michaela, Baichoo, Noel, Rausch, Jason, Le Grice, Stuart, Götte, Matthias
Published in Journal of molecular biology (08.05.2009)
Published in Journal of molecular biology (08.05.2009)
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Journal Article
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)
Lim, Shuhui, Khoo, Regina, Peh, Khong Ming, Teo, Jinkai, Chang, Shih Chieh, Ng, Simon, Beilhartz, Greg L., Melnyk, Roman A., Johannes, Charles W., Brown, Christopher J., Lane, David P., Henry, Brian, Partridge, Anthony W.
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
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Journal Article
Repurposing bacterial toxins for intracellular delivery of therapeutic proteins
Beilhartz, Greg L., Sugiman-Marangos, Seiji N., Melnyk, Roman A.
Published in Biochemical pharmacology (15.10.2017)
Published in Biochemical pharmacology (15.10.2017)
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Journal Article
An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth
Vidimar, Vania, Beilhartz, Greg L., Park, Minyoung, Biancucci, Marco, Kieffer, Matthew B., Gius, David R., Melnyk, Roman A., Satchell, Karla J. F.
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
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Journal Article
Impact of Primer-induced Conformational Dynamics of HIV-1 Reverse Transcriptase on Polymerase Translocation and Inhibition
Auger, Anick, Beilhartz, Greg L., Zhu, Siqi, Cauchon, Elizabeth, Falgueyret, Jean-Pierre, Grobler, Jay A., Ehteshami, Maryam, Götte, Matthias, Melnyk, Roman A.
Published in The Journal of biological chemistry (26.08.2011)
Published in The Journal of biological chemistry (26.08.2011)
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Journal Article
Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins
Lee, Hunsang, Beilhartz, Greg L., Kucharska, Iga, Raman, Swetha, Cui, Hong, Lam, Mandy Hiu Yi, Liang, Huazhu, Rubinstein, John L., Schramek, Daniel, Julien, Jean-Philippe, Melnyk, Roman A., Taipale, Mikko
Published in Cell (23.07.2020)
Published in Cell (23.07.2020)
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Journal Article
Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection"
Beilhartz, Greg L, Tam, John, Zhang, Zhifen, Melnyk, Roman A
Published in Science translational medicine (21.12.2016)
Published in Science translational medicine (21.12.2016)
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Journal Article
Small Molecules Take A Big Step Against Clostridium difficile
Beilhartz, Greg L, Tam, John, Melnyk, Roman A
Published in Trends in microbiology (Regular ed.) (01.12.2015)
Published in Trends in microbiology (Regular ed.) (01.12.2015)
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Journal Article
Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation
Beilhartz, Greg L., Ngure, Marianne, Johns, Brian A., DeAnda, Felix, Gerondelis, Peter, Götte, Matthias
Published in The Journal of biological chemistry (06.06.2014)
Published in The Journal of biological chemistry (06.06.2014)
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Journal Article
Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage
Tam, John, Beilhartz, Greg L., Auger, Anick, Gupta, Pulkit, Therien, Alex G., Melnyk, Roman A.
Published in Chemistry & biology (19.02.2015)
Published in Chemistry & biology (19.02.2015)
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Journal Article
Attenuated diphtheria toxin mediates siRNA delivery
Arnold, Amy E, Smith, Laura J, Beilhartz, Greg L, Bahlmann, Laura C, Jameson, Emma, Melnyk, Roman A, Shoichet, Molly S
Published in Science advances (01.05.2020)
Published in Science advances (01.05.2020)
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Journal Article
Derivatives of Mesoxalic Acid Block Translocation of HIV-1 Reverse Transcriptase
Bernatchez, Jean A., Paul, Rakesh, Tchesnokov, Egor P., Ngure, Marianne, Beilhartz, Greg L., Berghuis, Albert M., Lavoie, Rico, Li, Lianhai, Auger, Anick, Melnyk, Roman A., Grobler, Jay A., Miller, Michael D., Hazuda, Daria J., Hecht, Sidney M., Götte, Matthias
Published in The Journal of biological chemistry (16.01.2015)
Published in The Journal of biological chemistry (16.01.2015)
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