Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Unbekandt, Mathieu, Belshaw, Simone, Bower, Justin, Clarke, Maeve, Cordes, Jacqueline, Crighton, Diane, Croft, Daniel R, Drysdale, Martin J, Garnett, Mathew J, Gill, Kathryn, Gray, Christopher, Greenhalgh, David A, Hall, James A M, Konczal, Jennifer, Lilla, Sergio, McArthur, Duncan, McConnell, Patricia, McDonald, Laura, McGarry, Lynn, McKinnon, Heather, McMenemy, Carol, Mezna, Mokdad, Morrice, Nicolas A, Munro, June, Naylor, Gregory, Rath, Nicola, Schüttelkopf, Alexander W, Sime, Mairi, Olson, Michael F
Published in Cancer research (Chicago, Ill.) (15.04.2018)
Published in Cancer research (Chicago, Ill.) (15.04.2018)
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Journal Article
Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein
Samuel, Michael S., Rath, Nicola, Masre, Siti F., Boyle, Sarah T., Greenhalgh, David A., Kochetkova, Marina, Bryson, Sheila, Stevenson, David, Olson, Michael F.
Published in Genesis (New York, N.Y. : 2000) (01.12.2016)
Published in Genesis (New York, N.Y. : 2000) (01.12.2016)
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Journal Article
Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis
WANG, X.-J, GREENHALGH, D. A, AIBO JIANG, DACHENG HE, LING ZHONG, MEDINA, D, BRINKLEY, B. R, ROOP, D. R
Published in Oncogene (09.07.1998)
Published in Oncogene (09.07.1998)
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Journal Article
Identification of a Calcium-Inducible, Epidermal-Specific Regulatory Element in the 3'-Flanking Region of the Human Keratin 1 Gene
Rothnagel, Joseph A, Greenhalgh, David A, Gagne, Todd A, Longley, Mary A, Roop, Dennis R
Published in Journal of investigative dermatology (01.10.1993)
Published in Journal of investigative dermatology (01.10.1993)
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Journal Article
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21WAF-induced differentiation triggered by GSK3β inactivation and reduced AKT activity
Yao, Denggao, Alexander, Claire L, Quinn, Jean A, Chan, Weng-Chyn, Wu, Hong, Greenhalgh, David A
Published in Journal of cell science (15.05.2008)
Published in Journal of cell science (15.05.2008)
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Journal Article
Expression of a Dominant-Negative Type II Transforming Growth Factor β (TGF-β ) Receptor in the Epidermis of Transgenic Mice Blocks TGF-β -Mediated Growth Inhibition
Wang, Xiao-Jing, Greenhalgh, David A., Bickenbach, Jackie R., Jiang, Aibo, Bundman, Donnie S., Krieg, Thomas, Derynck, Rik, Roop, Dennis R.
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (18.03.1997)
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Journal Article
PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways
DENGGAO YAO, ALEXANDER, Claire L, QUINN, Jean A, PORTER, Michael J, HONG WU, GREENHALGH, David A
Published in Cancer research (Chicago, Ill.) (01.02.2006)
Published in Cancer research (Chicago, Ill.) (01.02.2006)
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Journal Article
Expression of Transfected DNA by Primary Murine Keratinocytes
Harper, John R., Greenhalgh, David A., Yuspa, Stuart H.
Published in Journal of investigative dermatology (01.08.1988)
Published in Journal of investigative dermatology (01.08.1988)
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Journal Article
Epidermis: An Attractive Target Tissue for Gene Therapy
Greenhalgh, David A, Rothnagel, Joseph A, Roop, Dennis R
Published in Journal of investigative dermatology (01.11.1994)
Published in Journal of investigative dermatology (01.11.1994)
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Journal Article
Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts
STRICKLAND, J. E, GREENHALGH, D. A, KOCEVA-CHYLA, A, HENNINGS, H, RESTREPO, C, BALASCHAK, M, YUSPA, S. H
Published in Cancer research (Chicago, Ill.) (1988)
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Published in Cancer research (Chicago, Ill.) (1988)
Journal Article
Inhibition of Melanoma Growth by Adenoviral-Mediated HSV Thymidine Kinase Gene Transfer In Vivo
Chen, Shu-Hsia, Bonnekoh, Bernd, Greenhalgh, David A., Bundman, Donnie S., Eckhardt, Joshua N., Longley, Mary Ann, Woo, Savio L.C., Roop, Dennis R.
Published in Journal of investigative dermatology (01.03.1995)
Published in Journal of investigative dermatology (01.03.1995)
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Journal Article
Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene
Greenhalgh, D A, Rothnagel, J A, Quintanilla, M I, Orengo, C C, Gagne, T A, Bundman, D S, Longley, M A, Roop, D R
Published in Molecular carcinogenesis (1993)
Published in Molecular carcinogenesis (1993)
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Journal Article
Abstract 930: Inducible ROCK 2/rasHa cooperation requires wound promotion to achieve malignancy in transgenic mouse skin carcinogenesis, whereas inducible ROCK 2/PTEN loss fails to achieve benign papilloma
Masre, Siti F., Samuel, Michael S., Olson, Michael F., Greenhalgh, David A.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Dissecting Molecular Carcinogenesis: Development Of Transgenic Mouse Models By Epidermal Gene Targeting
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Book Chapter
Journal Article
Abnormal Keratin 1 and 10 Cytoskeleton in Cultured Keratinocytes from Epidermolytic Hyperkeratosis Caused by Keratin 10 Mutations
Huber, Marcel, Scaletta, Corinne, Benathan, Messod, Frenk, Edgar, Hohl, Daniel, Greenhalgh, David A, Rothnagel, Joseph A, Roop, Dennis R
Published in Journal of investigative dermatology (01.05.1994)
Published in Journal of investigative dermatology (01.05.1994)
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Journal Article
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity
Yao, Denggao, Alexander, Claire L, Quinn, Jean A, Chan, Weng-Chyn, Wu, Hong, Greenhalgh, David A
Published in Journal of cell science (15.05.2008)
Published in Journal of cell science (15.05.2008)
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Journal Article
Targeting Gene Expression to the Epidermis of Transgenic Mice: Potential Applications to Genetic Skin Disorders
Rothnagel, Joseph A., Longley, Mary A., Bundman, Donnie, Greenhalgh, David A., Dominey, Andrea M., Roop, Dennis R.
Published in Journal of investigative dermatology (01.11.1990)
Published in Journal of investigative dermatology (01.11.1990)
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Journal Article
Conference Proceeding
PTEN Loss Promotes ras super(Ha)-Mediated Papillomatogenesis via Dual Up-Regulation of AKT Activity and Cell Cycle Deregulation but Malignant Conversion Proceeds via PTEN-Associated Pathways
Yao, Denggao, Alexander, Claire L, Quinn, Jean A, Porter, Michael J, Wu, Hong, Greenhalgh, David A
Published in Cancer research (Chicago, Ill.) (01.02.2006)
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Published in Cancer research (Chicago, Ill.) (01.02.2006)
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